FEATURED INSIGHTS

• Twist Of Two: 2D-LC For Oligos

  Discover how coupling orthogonal mechanisms reveals hidden impurities and creates a more robust strategy for characterizing complex oligonucleotide samples.

• A New Specialist For Oligonucleotides With Advantages

  Discover how hybrid silica technologies ensure stability and high resolution in IP-RP chromatography applications while protecting instrumentation from excessive wear and tear.

• The Secret To Pure Oligos: Why Anion Exchange Chromatography Rules At Scale

  Discover how anion exchange chromatography delivers high loading capacity and clinical-grade purity while addressing common scale-up challenges like aggregation and equipment longevity.

• How To Navigate Through The Jungle Of Columns?

  Whether prioritizing mass spectrometry compatibility or loading capacity, understanding the specific trade-offs between IP-RP, AEX, and SEC methodologies is essential for successful characterization.

• Size Matters: Mastering Size Exclusion For Oligos

  Learn how to separate molecules strictly by size, effectively remove salts, and select the correct pore specifications for a gentle, non-destructive purification workflow.

• Stick With Me: The Cool Chemistry Of HILIC Oligonucleotide Analysis

  Discover a powerful alternative for analyzing polar sequences without ion-pairing reagents. By leveraging hydrophilic partitioning, you can achieve sharper separation and improved mass spectrometry compatibility.

• The Sleek Science Of Ion Pair (IP)-Reversed Phase (RP) Oligonucleotide Analysis

  Master oligonucleotide separation by balancing hydrophobic and ionic interactions. Learn how selecting the right cationic pairing agent optimizes retention and ensures compatibility with mass spectrometry workflows.

• Charged For Action: The Hidden Secrets Of AEX Oligonucleotide Analysis

  Understanding how to fine-tune pH and ionic strength allows for the detection of truncated sequences and single-nucleotide variants, turning complex purification challenges into reproducible data.

• The Hitchhiker´s Guide To Creating Oligonucleotides From Start To Finish

  Producing high-quality oligonucleotides demands precise execution across multiple stages. Gain a clearer understanding of the complete mid-scale production workflow and necessary quality control measures.

• Targeted LC-MS/MS Detection Of Lipid Impurities In Lipid Nanoparticles

  Learn about an HPLC-MS/MS method for detecting lipid impurities in lipid nanoparticles (LNPs) and why it is critical for quality control of LNP-based drug delivery systems.

• Co-Precipitation Of Metal Carbonate Templated Protein Microparticles

  Explore the automated production of protein microparticles using an innovative method that offers a standardized and scalable solution for co-precipitation in biopolymer particle fabrication.

• Analysis Of LNP Lipids With Evaporative Light Scattering Detection

  Jump into this thorough analysis of lipids in LNP formulations using HPLC, a technique crucial for quality control in the production of mRNA vaccines and therapeutics.

• Development Of LNP Formulations Using The KNAUER NanoScaler

  Lipid nanoparticles (LNPs) offer a robust solution for nucleic acids. The NanoScaler system optimizes this technology, enabling scalable and reproducible LNP formulations for diverse applications.

• Quality Control Of Oligonucleotides Using HPLC Coupled To UV And MS Detection

  Efficient quality control of therapeutic oligonucleotides is crucial. Explore advanced methods combining HPLC-UV and mass spectrometry for precise impurity quantification and mass confirmation.

• Large Scale Purification Of Oligonucleotides With IEX

  As oligonucleotide-based drugs gain momentum in therapeutic development, refining their manufacturing processes through solutions like ion exchange chromatography (IEX) becomes crucial.

• High-Throughput Lipid Separation For LNP Formulations

  Lipid nanoparticles (LNPs) carry immense potential as delivery systems. Learn about the development of isocratic and gradient methods for high-throughput separation of lipids used in LNP formulations.

• Development And Optimization Of LNP Formulations

  The production of lipid nanoparticles (LNPs) is a process that demands robustness, scalability, and reproducibility. Examine the impact of key operational parameters on the efficacy of LNPs.

• Scaling Of Impingement Jets Mixing For LNP Drug Production

  Delve into the intricacies of Impingement Jets Mixing (IJM) technology and its pivotal role in the scalable and reproducible production of Lipid Nanoparticles (LNPs) for drug delivery.