ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS

• Production And Clarification Of Lentiviral Vectors

  Explore scalable processes for lentiviral vector production and clarification at the 50 L scale, utilizing the CTS LV-MAX system and single-use bioreactors for robust gene therapy manufacturing.

• Improvement Of Self-Amplifying RNA Quality And Potency With IVT Optimization

  Explore our study on optimizing In-Vitro Transcription (IVT) conditions for self-amplifying RNAs to achieve high yields, low residual dsRNA, and improved potency, and learn how these advancements can enhance RNA-based therapies.

• A New Centre For Continuous mRNA Manufacturing

  Explore how a partnership between academia, regulatory agencies, and manufacturing organizations has the potential to reshape the way we produce and distribute mRNA-based therapies.

• Purification And QC Of An RNA 21‑Mer Oligonucleotide Via LC‑MS

  Learn how buffer choice, gradient strategy, and pretreatment steps influence recovery, purity, and resolution when purifying a native RNA oligo, with analytical confirmation and practical guidance.

• Unlocking The Full Potential Of Genomic Medicine

  There are two key challenges to realizing the potential of genomic medicines, but potential technological solutions are on the horizon, and we examine each.

• Genome Editing of Human Primary T Cells With Lipid Nanoparticles

  We show CRISPR/Cas9-mediated knockouts of the T cell receptor and explore multi-step LNP engineering to produce TCRɑβ KO CAR T cells, a promising approach towards allogeneic CAR T cell therapy.

• Rapid Separation Of Circular RNA Using An mRNA Analysis Kit

  Achieve high-resolution separation of circular RNA (circRNA) species from linear RNA products, and detect impurities present at 0.1% of that main product, using an mRNA analysis kit.