ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS

• Is Standardization The Key To Scalable CGT?

  Experts note CGT programs often struggle due to limited operational readiness; early standardization supports scalable, reproducible, regulatory‑ready development and helps prevent late‑stage bottlenecks.

• Genome Editing of Human Primary T Cells With Lipid Nanoparticles

  We show CRISPR/Cas9-mediated knockouts of the T cell receptor and explore multi-step LNP engineering to produce TCRɑβ KO CAR T cells, a promising approach towards allogeneic CAR T cell therapy.

• Optimization And Scale-Up Of A Plasmid DNA Production Process

  Optimizing pDNA production in E. coli requires strategic media selection and scale-up planning. Explore a study that identifies ideal conditions for high-yield manufacturing.

• Rapid Separation Of Circular RNA Using An mRNA Analysis Kit

  Achieve high-resolution separation of circular RNA (circRNA) species from linear RNA products, and detect impurities present at 0.1% of that main product, using an mRNA analysis kit.

• Development And Optimization Of LNP Formulations

  The production of lipid nanoparticles (LNPs) is a process that demands robustness, scalability, and reproducibility. Examine the impact of key operational parameters on the efficacy of LNPs.

• Drug Discovery And Screening, A Digital Era For RNA-LNP Therapeutics

  Learn about the key stages of drug discovery and screening as well as how to overcome bottlenecks in screening mRNA-LNPs to rapidly develop genomic medicines.

• Cell Therapy Manufacturing: The Supply Chain Challenge

  Overcoming the challenges of manufacturing and administering a complex product to any patient is critical for delivering cell therapies. Two industry experts detail strategies to meet supply chain challenges.