Oligonucleotide Synthesis – KNAUER Devices Can Do Even More Than Liquid Chromatography

Oligonucleotides service a diverse range of applications in pharmaceuticals and therapeutics. Their surge in demand has fueled the need for more efficient and reliable synthesis methods. KNAUER, known for its Liquid Chromatography expertise, has demonstrated the application of its devices in oligonucleotide synthesis. The company's existing LC devices, including pumps, valves, and detectors, were tested in a proof-of-concept oligonucleotide synthesis setup.

The successful synthesis of DNA and RNA test sequences, with results comparable to established synthesizers, proves the feasibility of KNAUER's approach. Notably, the process showed improvements in both crude yield and purity. This successful adaptation suggests that KNAUER's devices can be effectively utilized for oligonucleotide synthesis across various scales.

To learn more about KNAUER's oligonucleotide synthesis solution, access the full content here.