Targeted LC-MS/MS Detection Of Lipid Impurities In Lipid Nanoparticles

Ensuring the quality and safety of lipid nanoparticles (LNPs) requires rigorous analysis of lipid impurities. This study presents a workflow for the targeted detection of these impurities using HPLC-MS/MS. The workflow allows monitoring of impurities even when standards are unavailable, enabling comprehensive quality control. The method also facilitates the identification and quantification of lipids in LNP formulations.

This approach is crucial for assessing the stability and safety of LNPs, especially given their sensitivity to oxidation. By accurately detecting and characterizing impurities, researchers can ensure the efficacy and safety of LNP-based drug products.

To learn more, access the full application note for detailed insights into this crucial aspect of LNP quality control.