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• In Vivo Genetic Medicines Need a Guide: The Answer Lies in Harnessing the Transcriptome

  This article by Radar Therapeutics explains why the DNA/RNA revolution is underway and why solving specific targeting is next.

• End-To-End mRNA DS And DP Manufacturing Processes

  This article demystifies the manufacture of mRNA encapsulated in lipid nanoparticles across unit operations for plasmid linearization, drug substance (DS) manufacture, and drug product (DP) manufacture.

• Innovation Advances In mRNA Medicine

  The post-pandemic mRNA pipeline surge has led to a substantial investment in innovation. Let’s look at nonamplifying mRNA, saRNA, and circRNA.

• Making Cancer Vaccines Is Complex; New Platform Guidance Could Help

  FDA's draft guidance on platforms is mostly for established, well-characterized modalities, but it also has implications for the emerging area of personalized medicine.

• CRISPR-Cas Genome Editing For Rejuvenation Of Aging Stem Cells

  As stem cells age, their regenerative capacity declines due to accumulated genetic and epigenetic changes. Using CRISPR-Cas, scientists can directly edit these changes or modulate aging-related pathways.