Customized Skid For Large Lipid Nanoparticle (LNP) Production And Formulation: IJM NanoProducer
The Impingement Jets Mixing (IJM) Large Production Scale Units are designed for high-flow production of nanoparticles (LNP, micro-emulsions, etc) and can be configured with up to eight parallel mixing units depending on customer requirements.
Features
- High-pressure dosing pumps 80P
- Coriolis flow meters
- IJM mixers
- Inlet manifolds for lipid/ethanol mixture and
- mRNA/buffer mixture
- Outlet manifold for LNP solution
- Back-seal washing system
Each unit consists of two pumps to deliver lipid and API streams, two flowmeters for flow control, and one jet mixer. Depending on the configuration, the predilution of the API and quenching can be performed for the combined flow of all units in one process step outside the Impingement Jets Mixing (IJM) Production Scale Unit.
The number of parallel units depends on the application. Also, the number of pumps, flowmeters, jets mixers, and pipes can be adapted to the required conditions and scale. All skids are built in a stainless steel frame on casters and are suitable for CIP cleaning procedures in pharmaceutical production.