Addressing The Challenges Of LNP Upscaling: A Reynolds Number-Driven Approach Via Junction Mixing Technologies

The journey to translate lipid nanoparticle (LNP) formulations from the lab bench to full-scale clinical and industrial production faces a major hurdle: maintaining quality and consistency when process volume changes. As scale increases, shifts in fluid dynamics can drastically alter critical quality attributes (CQAs), making the reliable manufacture of mRNA-based therapeutics incredibly difficult.

This on-demand webinar reveals how junction mixing technologies—specifically Impingement Jets Mixing (IJM)—provide a physics-informed solution for this challenge. By focusing on maintaining constant flow conditions, characterized by the Reynolds number, IJM mixers ensure reproducible turbulence and consistent mixing across all development stages. We’ll present a framework that integrates fundamental fluid mechanical principles into your formulation design. Discover the empirical correlation between the Reynolds number and key LNP quality outcomes, and learn how to achieve safe, reproducible upscaling from R&D to global deployment. Watch the webinar to bridge the gap between engineering and pharmaceutical innovation.