Co-Precipitation Of Metal Carbonate Templated Protein Microparticles

The co-precipitation step is crucial in determining the size and morphology of biopolymer particles. Traditionally, this step involves the manual mixing of inorganic salt solutions containing biopolymers, leading to inconsistencies and challenges in scalability. This study investigates the feasibility of replacing the manual co-precipitation step with the automated Impingement Jets Mixing (IJM) technology of the KNAUER NanoScaler. The research focuses on achieving particle sizes ranging from 0.1 to 10 µm and examines the impact of additives on particle size and aggregation.

By automating the process with the KNAUER IJM NanoScaler, and with the addition of suitable additives like dextran, the study demonstrates the production of protein-metal carbonate hybrid particles with low aggregation and a narrow size distribution. This approach offers significant potential for the standardized, scalable, and GMP-compliant production of biopolymer particles for various applications, including drug delivery and oxygen carriers.

To learn more about this innovative approach to particle fabrication, access the full content here.