ANALYTICAL/QUALITY ARTICLES
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![genetic engineering and gene manipulation, CRISPR technology, genome editing, molecular biotechnology, genetic science research, gene therapy-GettyImages-2196575232]( "From Supporting Component to Strategic Driver: The Evolving Role of gRNA in CRISPR Therapeutics")
From Supporting Component to Strategic Driver: The Evolving Role of gRNA in CRISPR TherapeuticsGuide RNA is evolving from a simple targeting reagent into a complex, engineered molecule shaped by expanding CRISPR modalities, increasing length and modification demands, and tighter integration with manufacturability, analytical control, and regulatory expectations.
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![RNA, ribonucleic acid-GettyImages-2195556279]( "5 Key Questions On How To Accelerate mRNA Development")
5 Key Questions On How To Accelerate mRNA DevelopmentStakeholders are working to solve key mRNA manufacturing challenges, including how raw materials impact product quality and how to address scale up. Though existing analytical and manufacturing technologies may fall short for mRNA, investment in innovative techniques will help meet increasing demand for personalized therapeutics.
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![Business support, teamwork-GettyImages-2267605245]( "The RNA Ties That Bind: 3 Takeaways From The OPT Congress")
The RNA Ties That Bind: 3 Takeaways From The OPT CongressHere, I unpack three takeaways I had from the OPT Congress, each of which I’d argue are indicative of the interconnectedness across the genetic medicines field.
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![Test Tubes-GettyImages-139700261]( "Rethinking ATMP Assurance When Sterility Timelines, Reality Misalign")
Rethinking ATMP Assurance When Sterility Timelines, Reality MisalignThe compendial 14-day sterility testing window exposes product and patient to numerous risks, but settling on a rapid alternative also presents its own set of challenges.
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![Liver Pop Art-GettyImages-531038489]( "MicroRNA Therapeutics In Metabolic Liver Disease: Context-Driven Drug Discovery")
MicroRNA Therapeutics In Metabolic Liver Disease: Context-Driven Drug DiscoveryRealizing the therapeutic potential of miRNAs in liver disease requires confronting a problem the field has not fully reckoned with.
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![Game Strategy-GettyImages-169983235]( "Inside Alnylam's Playbook For High Volume siRNA Production")
Inside Alnylam's Playbook For High Volume siRNA ProductionAs one of the first companies to establish a chemoenzymatic ligation platform, Alnylam's Maines and Nechev are in the perfect position to espouse wisdom on the practical aspects and remaining challenges of implementing enzymatic ligation at a large scale. Here in this installment, Maines and Nechev outline what they’ve learned thus far about the science of enzymatic ligation, while also paying credence to the unknowns and existing barriers that, as a frontrunner, Alnylam will inevitably (but willingly) be tasked with facing in the future.
ANALYTICAL/QUALITY VIDEOS
Explore how early-stage companies can implement design space and analytical principles that will help us determine the biggest differences between constructs and how close we may be to a true “platform process.”
Explore why process-related impurities are a concern in vaccines and present results and learnings from LC-MS analyses of several mRNA- and protein-based vaccines for COVID-19.
Experts from this Advancing RNA Live panel discuss the results from a poll question revealing the top three areas RNA industry experts would be most interested in seeing additional mRNA-specific guidance from regulatory agencies.
Do we need more specific regulatory guidance for every RNA modality and therapeutic approach? We asked and the Advancing RNA Live audience answered… Here, panelists Tiffany Lucas and Ulrike Jägle address the audience’s responses, as well as share their thoughts on just how prescriptive the future of regulatory guidance for RNA therapeutics approaches could/should be..
ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS
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![GettyImages-2158124620-scientist-laboratory-containers-testing-analysis]( "Accelerating IND-Enabling Studies With Automated Bioanalysis Workflows")
Accelerating IND-Enabling Studies With Automated Bioanalysis WorkflowsReimagined as automation-first, bioanalysis shifts from being an Investigational New Drug (IND) bottleneck to a catalyst for innovation—helping companies move therapies forward with greater confidence.
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![GettyImages-1437856375-lnp-lipid-nanoparticle]( "Nanomedicine Modalities Find Path To Clinic Through Analytics")
Nanomedicine Modalities Find Path To Clinic Through AnalyticsLipid nanoparticles have revolutionized drug delivery, ushering in a new era of nanomedicine. Discover how advanced analytical tools are accelerating next-generation LNP therapeutics.
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![Thermo Fisher - Peptones]( "The Value Of Peptones For Enhancing Biopharmaceutical Productivity")
The Value Of Peptones For Enhancing Biopharmaceutical ProductivityPeptones, versatile media additives derived from various sources, offer numerous benefits for biopharmaceutical production.
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![Fragment-Analyzer_Agilent_0544_screen]( "Preventive Control Of Sequencing Through The Insert")
Preventive Control Of Sequencing Through The InsertUnderstanding library size distributions helps prevent sequencing through the insert, reducing adapter read‑through. Explore how smear analysis guides optimal read‑length selection to avoid noise.
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![GettyImages-1183908006 bioanalysis]( "The Future Of Small And Large Molecule Bioanalytics")
The Future Of Small And Large Molecule BioanalyticsLearn how innovative, emerging technologies are revolutionizing the field of bioanalytics and drug development.
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![mRNA GettyImages-1428646288]( "Solutions For CQA Analysis Of IVT mRNA-Based Biotherapeutics")
Solutions For CQA Analysis Of IVT mRNA-Based BiotherapeuticsDiscover new innovative solutions for mRNA analysis, enhancing accuracy and efficiency in IVT mRNA workflows, including advanced technologies and methodologies to optimize your research and development processes.
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![GettyImages-1067806062-scientist-lab-vaccine-vial]( "Quality Assurance In IVT RNA Vaccine Development Using Electrophoresis")
Quality Assurance In IVT RNA Vaccine Development Using ElectrophoresisDiscover advanced solutions for IVT RNA synthesis, focusing on enhancing fidelity in throughput, innovative technologies, and methodologies to optimize your RNA research and development processes.
