ANALYTICAL/QUALITY ARTICLES

ANALYTICAL/QUALITY VIDEOS

Why are so many sponsors shifting from Ligand-Binding Assays (LBA) to Liquid Chromatography-Mass Spectrometry (LC-MS) for large molecule protein analysis?

As CRISPR technology evolves beyond the original Cas9, gRNAs are transitioning from simple targeting tools into highly engineered, complex molecules. In this Advancing RNA Live segment, speakers April Sena, Max De Long, and Venkat Krishnamurthy discuss how the rise of diverse nucleases — including prime editors — is impacting gRNA synthesis and purity.

Here, we describe the use of cutting-edge technologies to assess critical quality attributes of both mRNA drug substances and drug products.

Take an exploration of the therapeutic potential of hfCas12Max, showcasing its advantages over existing CRISPR nucleases and its role in accelerating the development of life-saving treatments.

ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS