ANALYTICAL/QUALITY ARTICLES
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![dna, rna molecules-GettyImages-537327406]( "A Guide To Designing mRNA Medicines")
A Guide To Designing mRNA MedicinesA poorly designed mRNA sequence can create ongoing difficulties during downstream clinical development and manufacture. Let's take a closer look at strategies and design software that you can employ.
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![RNA and protein with transparent molecules-GettyImages-2197698139]( "Designing Our Way Toward Circular RNA Medicines With AI")
Designing Our Way Toward Circular RNA Medicines With AIThe closed-loop structure of circular RNA can offer sustained, durable expression. We caught up with Sail Biomedicines' Kerry Benenato and Rajesh Ramaswamy to chat about ways to leverage AI for design/engineering.
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![business analytics, data management, strategy-GettyImages-1408832606]( "A Road Map For PAT Monitoring And Control")
A Road Map For PAT Monitoring And ControlProcess analytic technology monitoring and control is rapidly progressing. BioPhorum shares new best practices on how to move from concept through life cycle management and/or regulatory approval of the PAT application.
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![syringe, vaccine, europe flag-GettyImages-1285131583]( "EMA Issues Draft Guideline On Quality Aspects Of mRNA Vaccines")
EMA Issues Draft Guideline On Quality Aspects Of mRNA VaccinesThe EMA's new draft guideline applies to mRNA vaccines for infectious diseases, providing guidance on manufacturing, characterization, specifications, and more. The deadline for public comments is Sept. 30, 2025.
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![Genetic Research-GettyImages-477335408]( "Do We Really Understand Plasmid Quality's Effects On mRNA Production?")
Do We Really Understand Plasmid Quality's Effects On mRNA Production?Two experts examine the current guidelines and specs for plasmid DNA and question whether our understanding is sufficient.
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![quality control, approval-GettyImages-2170531311]( "ICH Revises Q1 Guideline, Advancing Stability Testing Standards")
ICH Revises Q1 Guideline, Advancing Stability Testing StandardsIn April 2025, the International Council for Harmonisation (ICH) released draft ICH Q1: Stability Testing of Drug Substances and Drug Products for public consultation. This new draft guideline represents the first major overhaul of global stability testing standards in over two decades.
ANALYTICAL/QUALITY VIDEOS
Gain key insights into your biomolecules' structure and stability with an advanced, automated measurement technique. Unlock precise, label-free analysis across diverse sample types and conditions.
When characterizing 3’ poly(A) tail length and integrity, Droplet Digital PCR technology demonstrates an orthogonal or alternative method to help ensure the quality and consistency of mRNA products.
In this clip from a recent Advancing RNA LIVE event, panelists address a question about where the best opportunities exist upstream and/or downstream to increase mRNA manufacturing efficiencies.
Optimize mRNA development by learning key strategies for process refinement, critical component identification, and in-process analytics to enhance therapeutic production.
ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS
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![GettyImages-1067806062-scientist-lab-vaccine-vial]( "Quality Assurance In IVT RNA Vaccine Development Using Electrophoresis")
Quality Assurance In IVT RNA Vaccine Development Using ElectrophoresisDiscover advanced solutions for IVT RNA synthesis, focusing on enhancing fidelity in throughput, innovative technologies, and methodologies to optimize your RNA research and development processes.
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![Nucleic acid sequence DNA GettyImages-1344985871]( "Nucleases - Are They A Problem For NAB Nanosep® Centrifugal Devices?")
Nucleases - Are They A Problem For NAB Nanosep® Centrifugal Devices?We examine whether the sample tubes and collection tubes of the NAB Nanosep centrifugal devices contain detectable amounts of DNase or RNase.
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![iStock-1213713667-viral-vector-virus]( "Gene Therapy And Oligonucleotide Compendium")
Gene Therapy And Oligonucleotide CompendiumTechnical summaries and detailed protocols for purity testing, sizing, sequencing and expression analysis of oligonucleotide-based active agents as well as protein and lipid-based delivery systems.
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![GettyImages-1145414430_Oligonucleotides]( "Selection And Evaluation Of Hybridization Capture Probes For LC/MS Analysis Of Oligonucleotides")
Selection And Evaluation Of Hybridization Capture Probes For LC/MS Analysis Of OligonucleotidesTo overcome challenges in oligonucleotide LC/MS bioanalysis, consider optimizing probe design by evaluating alternative chemistries like PNA for improved recovery and chromatographic performance.
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![GettyImages-1355122387 RNA]( "Limiting Off-Target Effects Of CRISPR-Based Products")
Limiting Off-Target Effects Of CRISPR-Based ProductsFind out how to enhance CRISPR gene editing specificity by using Next Generation Sequencing to improve sgRNA quality control, addressing off-target effects and ensuring higher sequence fidelity.
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![iStock-178131492-lab-research-beaker]( "Extending The Lower Limits Of Quantification Of A Therapeutic Oligonucleotide Through Microflow LC-MS/MS")
Extending The Lower Limits Of Quantification Of A Therapeutic Oligonucleotide Through Microflow LC-MS/MSHere a solution is presented to widely recognized challenges with ionpairing reversed phase liquid chromatography (IP-RP LC) through a novel microflow LC-MS strategy.
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![Gett images-542576580 bio]( "Top 5 Approaches To The Bioanalysis Of Oligonucleotides")
Top 5 Approaches To The Bioanalysis Of OligonucleotidesEvaluate the strengths and limitations of each bioanalysis method carefully to choose the most effective strategy for your clinical study.
