ANALYTICAL/QUALITY ARTICLES
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![Measuring Success GettyImages-1319232417]( "How Should We Measure The True Potency Of RNA Therapeutics?")
How Should We Measure The True Potency Of RNA Therapeutics?An RNA therapeutic can generate a strong molecular signal without producing the intended biological function. Let's look at how best to predict whether the RNA has completed its task.
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![creativity, innovation-GettyImages-2209122228]( "Engineering RNA Agonists For Systemic Immunity Without Systemic Toxicity")
Engineering RNA Agonists For Systemic Immunity Without Systemic ToxicityKrieg believes the answer lies in a deeper understanding of innate immune biology and the design of RNA/DNA hybrid mimics of viral RNA and DNA that are detected by innate immune receptors.
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![data analytics, financial investment-GettyImages-2154830395]( "Why RNA–LNP Development Needs Higher-Resolution Analytics In 2027")
Why RNA–LNP Development Needs Higher-Resolution Analytics In 2027Raising analytical resolution is among the cheapest interventions available. With regulators tightening and capital selective, it is also among the most consequential.
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![Justified Risk-GettyImages-2232143649]( "What Oligo Manufacturing Risks Are We Underestimating?")
What Oligo Manufacturing Risks Are We Underestimating?Earlier this year, I attended the OPT Congress, where I had the great fortune of meeting consultant Marc Lemaitre. I recently sat down with Lemaitre for a follow-up interview to gauge some of the evolutions he’s been watching within the CMC landscape for oligo development. Here, he digs into the shifts in quality he’s noted, pointing out some of the potential pitfalls we may encounter in our manufacturing that could stand to impact the overall quality of our oligos.
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![business leadership-GettyImages-2251075536]( "Will 2027 See A Meteoric Rise Of Programmable Nanomedicine?")
Will 2027 See A Meteoric Rise Of Programmable Nanomedicine?The significance of programmable nanomedicines is not simply that nanoparticles can carry more functions. It is that biological information can become part of the control logic.
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![new ideas, innovation, business-GettyImages-2182048387]( "From Cell State Reprogramming To The Clinic: Turning The Regulatory Genome Into RNA Medicines (Pt. 2)")
From Cell State Reprogramming To The Clinic: Turning The Regulatory Genome Into RNA Medicines (Pt. 2)Ounzain discusses how regulatory genome biology is being translated into drug discovery, from identifying lncRNA targets to building clinically relevant therapeutics and more.
ANALYTICAL/QUALITY VIDEOS
NxGen Technology delivers a scalable means to perform the critical particle formation step in a nanomedicine development process.
Though there are a lot of exciting advancements being made with novel lipid chemistries, CMC Consultant Sujit Jain provides an important reality check for us: These innovations break established platforms, requiring fresh process development, complex impurity profiling, and new vendor qualifications.
ReciBioPharm’s Melanie Cerullo shares where mRNA needs to “catch up” to its oligonucleotide “cousin” molecules and where regulatory differences may be emerging between modalities.
What is Bio-Layer Interferometry (BLI)? Watch to learn about BLI and the advantages of utilizing a proven BLI platform.
ARTICLES, APP NOTES, CASE STUDIES, & WHITE PAPERS
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![GettyImages-2232165715-oligonucleotide-render-3d]( "Comprehensive Characterization Of Oligonucleotides And Related Impurities")
Comprehensive Characterization Of Oligonucleotides And Related ImpuritiesA two-dimensional LC/MS strategy improves the separation of coeluting oligonucleotide impurities. High-resolution sampling and automation enable deeper characterization of low-level variants.
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![GettyImages-1026622810 chromatography column]( "How To Navigate Through The Jungle Of Columns?")
How To Navigate Through The Jungle Of Columns?Whether prioritizing mass spectrometry compatibility or loading capacity, understanding the specific trade-offs between IP-RP, AEX, and SEC methodologies is essential for successful characterization.
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![Five Essentials Feature]( "Five Essentials For Accurate Oligonucleotide Chemistry")
Five Essentials For Accurate Oligonucleotide ChemistryExplore five key areas in oligonucleotide chemistry where improvements will have a huge influence on your synthesis quality.
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![Molecule mRNA-GettyImages-1428646288]( "Optimizing mRNA For Success: A Guide To Enhanced Stability, Delivery, And Efficacy")
Optimizing mRNA For Success: A Guide To Enhanced Stability, Delivery, And EfficacyRNA offers exciting potential for vaccines, gene therapies, and personalized medicine, but challenges related to stability, delivery, and manufacturing persist.
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![Thermo Fisher - Peptones]( "The Value Of Peptones For Enhancing Biopharmaceutical Productivity")
The Value Of Peptones For Enhancing Biopharmaceutical ProductivityPeptones, versatile media additives derived from various sources, offer numerous benefits for biopharmaceutical production.
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![mRNA GettyImages-1428646288]( "Establishing Analytical Methods For mRNA-Based Therapies")
Establishing Analytical Methods For mRNA-Based TherapiesHere, we provide a detailed description of assays for sequence identification and LNP composition in mRNA-LNP products that support the development of safe and effective mRNA therapies.
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![Scientist in HPLC lab GettyImages-1309780330]( "Twist Of Two: 2D-LC For Oligos")
Twist Of Two: 2D-LC For OligosDiscover how coupling orthogonal mechanisms reveals hidden impurities and creates a more robust strategy for characterizing complex oligonucleotide samples.
