RNA Analytical Quality/Resources

  1. Engineered Enzymes Powering The Future Of mRNA Therapeutics 1/12/2026

    Optimizing RNA polymerase selection significantly improves mRNA yield and purity while reducing dsRNA. Discover how advanced enzyme engineering enhances therapeutic manufacturing efficiency and safety.

  2. Elevating mRNA Manufacturing Toward GMP-Readiness 8/27/2025

    The mRNA Technology Transfer Program empowers LMICs with scalable vaccine production. Learn about a partnership that drives innovation in mRNA and sets a global blueprint for equitable health access.

  3. Potent Immune Response With Vernal's LNP-mRNAs 4/26/2024

    As mRNA medicine continues to evolve, understand how trusted manufacturing partners will continue to play a pivotal role in translating innovative concepts into clinical reality.

  4. Optimizing qPCR For Broad-Range Transcript Detection In Anti-PD-1 Therapy 4/23/2025

    Optimize qPCR protocols for greater sensitivity and reproducibility to accurately measure immune-related gene expression and better identify patients who will benefit from anti-PD-1 immunotherapy.

  5. How Polymerase Selection Shapes IVT Outcomes: Insights From An Independent Evaluation 4/13/2026

    dsRNA contamination starts with polymerase choice. See how engineered RNA polymerases cut dsRNA by more than 10x compared to wild-type T7 in independent IVT testing.

  6. Novel Plasmid DNA-Encoded Poly(A) Tails For mRNA Synthesis 4/26/2024

    Here, we evaluate the stability of these variant poly(A) regions and the biological activity of the mRNA containing the variant poly(A) tails made from these templates.

  7. Why RNA Diversity Is Raising The Bar For Platform-Aware IVT Design 7/29/2026

    RNA therapeutics now span multiple construct types, each placing distinct demands on in vitro transcription design. Platform-aware IVT thinking is becoming essential as workflows grow more complex.

  8. High-Sensitivity IVT mRNA Analysis 2/20/2025

    Quality analysis of in vitro transcribed (IVT) has become an essential part of biotherapeutic workflows. Discover a high-sensitivity kit made for analyzing IVT mRNA quality to advance your research.

  9. Sequencing Of Synthetic Oligonucleotides And Their Impurities 9/20/2022

    We demonstrate an automated, compliance-ready liquid chromatography-mass spectrometry (LC-MS) workflow for sequence confirmation of oligonucleotides and their impurities.

  10. Selection And Evaluation Of Hybridization Capture Probes For LC/MS Analysis Of Oligonucleotides 4/23/2025

    To overcome challenges in oligonucleotide LC/MS bioanalysis, consider optimizing probe design by evaluating alternative chemistries like PNA for improved recovery and chromatographic performance.