RNA Analytical Quality/Resources

1. Learn How Compliance-Ready LC-MS Workflows for Oligonucleotides Can Expand your Analytical Services Portfolio 2/22/2022

   CMO invests in solution to ensure data integrity and meet regulatory requirements as they expand their oligonucleotide manufacturing and analysis services.

2. Charged For Action: The Hidden Secrets Of AEX Oligonucleotide Analysis 12/15/2025

   Understanding how to fine-tune pH and ionic strength allows for the detection of truncated sequences and single-nucleotide variants, turning complex purification challenges into reproducible data.

3. Detection Of Adapter Dimers In NGS Libraries 3/4/2026

   Accurately identifying low‑level adapter dimers is key. Compare electrophoresis methods to show how different kits detect and resolve small fragments, helping researchers choose the best QC approach.

4. Streamlining The Importing & Exporting Of Biological Samples 9/1/2024

   Create a seamless and predictable import and export process by working with experienced bioanalytical laboratory partners, understanding what paperwork samples require, and proactive planning.

5. The Next Generation Of mRNA Products: Implications For Quality Control 5/30/2024

   To fully realize the potential of mRNA as a therapeutic or vaccine modality, developers will need to employ cutting-edge analytical methods to ensure the safety and efficacy of these novel products.

6. Stick With Me: The Cool Chemistry Of HILIC Oligonucleotide Analysis 12/15/2025

   Discover a powerful alternative for analyzing polar sequences without ion-pairing reagents. By leveraging hydrophilic partitioning, you can achieve sharper separation and improved mass spectrometry compatibility.

7. Exploring Osmolality As A CQA Within RNA Therapeutics 10/3/2023

   Discover how osmolality can be applied throughout the bioprocessing workflow for RNA, and recognize the importance of this sensitive measurement, from formulation optimization to cryopreservation techniques.

8. A&M STABTEST Expands Service Offerings In Protein And Oligonucleotide Analysis With LC-MS System 2/22/2022

   CRO upgrades systems to provide regulatory compliance for large-molecule protein analysis, expanding their oligonucleotides capabilities.

9. Top 5 Approaches To The Bioanalysis Of Oligonucleotides 9/1/2024

   Evaluate the strengths and limitations of each bioanalysis method carefully to choose the most effective strategy for your clinical study.

10. Pre-Banking And Avoiding Manufacturing Challenges For GMP Plasmids Containing Unstable Sequence Regions 4/21/2021

    Ensuring consistent replication and proper retention of plasmid DNA sequence is vital to the economics and efficiency in generating starting materials used for production of AAV delivered gene therapy and mRNA vaccines and therapeutics.