RNA Analytical Quality/Resources

1. How Polymerase Selection Shapes IVT Outcomes: Insights From An Independent Evaluation 4/13/2026

   dsRNA contamination starts with polymerase choice. See how engineered RNA polymerases cut dsRNA by more than 10x compared to wild-type T7 in independent IVT testing.

2. Top 8 Benefits Of Mass Spectrometry Imaging Early In Drug Development 9/1/2024

   Here we explore the top 8 benefits of using mass spectrometry imaging in the oncology drug discovery and early development stages.

3. Determining RNA Integrity And Purity By Capillary Gel Electrophoresis 6/30/2023

   To ensure mRNA product quality, it's important to confirm the integrity of the RNA. Examine the results of a study challenging the performance of the CGE method in assessing mRNA integrity and purity.

4. Metabolite ID And Relative Quantification Of Oligonucleotides In Plasma 3/4/2022

   This technical note describes the identification, relative quantification, and structural confirmation of the chain-shortened metabolites of a phosphorothioated oligonucleotide.

5. Quality Assurance In IVT RNA Vaccine Development Using Electrophoresis 2/20/2025

   Discover advanced solutions for IVT RNA synthesis, focusing on enhancing fidelity in throughput, innovative technologies, and methodologies to optimize your RNA research and development processes.

6. Large Scale Purification Of Oligonucleotides With IEX 12/6/2024

   As oligonucleotide-based drugs gain momentum in therapeutic development, refining their manufacturing processes through solutions like ion exchange chromatography (IEX) becomes crucial.

7. From Data To Decisions: Accelerating Your mRNA Drug Development With Analytics 11/20/2024

   To stay ahead in the competitive landscape of mRNA development, adopt a comprehensive QC strategy today and begin conducting meaningful tests to ensure the quality of your test articles.

8. Twist Of Two: 2D-LC For Oligos 12/16/2025

   Discover how coupling orthogonal mechanisms reveals hidden impurities and creates a more robust strategy for characterizing complex oligonucleotide samples.

9. A New Era Of mRNA Potency And Safety 6/10/2026

   Selecting the right RNA polymerase and cap analog pairing significantly impacts mRNA yield, purity, and immunogenic safety, yet many production workflows still rely on a single industry-standard enzyme.

10. Limiting Off-Target Effects Of CRISPR-Based Products 2/11/2025

    Find out how to enhance CRISPR gene editing specificity by using Next Generation Sequencing to improve sgRNA quality control, addressing off-target effects and ensuring higher sequence fidelity.