RNA Analytical Quality/Resources

1. Reduce Contamination Risks When Storing Synthetic DNA 10/30/2023

   An alternative to traditional polyethylene bags is offering cell and gene therapy manufacturers a solution to contamination concerns regarding DNA or RNA fragments.

2. Leveraging Filtration Plates To Accelerate The Detection Of Vitamin B6 In Clinical Samples For Research Purposes 6/9/2022

   By employing a simple strategy many different lab protocols where filtration is required can be accelerated. Learn more about automation-friendly 96-well filter plates that enable more samples to be filtered in one go.

3. A Risk-Based Approach To Plasmid DNA And mRNA Process Development 9/23/2025

   Balancing robust analytics and clinical readiness is key for early-phase pDNA and mRNA therapeutics amid structural complexity and regulatory challenges.

4. Quantification Of Large Oligonucleotides Using High Resolution MS/MS 3/4/2022

   Explore how to achieve sensitive, high-resolution analysis of large oligonucleotides, with the opportunity to perform both qualitative and quantitative analysis in a single run.

5. Sequencing Of Synthetic Oligonucleotides And Their Impurities 9/20/2022

   We demonstrate an automated, compliance-ready liquid chromatography-mass spectrometry (LC-MS) workflow for sequence confirmation of oligonucleotides and their impurities.

6. Future-Proofing mRNA Drug Manufacturing: The Value of Continuous Improvement 4/30/2024

   With so many uncertainties permeating the mRNA market, this largely preclinical industry is still seeking answers on how to reach successful therapeutic development. Identifying optimizations, both sequence-dependent and otherwise, to enhance the manufacturing process is crucial for advancing mRNA product development, which holds vast potential to address a wide range of indications.

7. Best Practices For Analysis Of In Vitro Transcribed (IVT) mRNA 11/20/2025

   Learn best practices for high-resolution analysis of IVT RNA using automated capillary electrophoresis. Improve accuracy and precision in quantifying critical quality attributes.

8. Pre-Banking And Avoiding Manufacturing Challenges For GMP Plasmids Containing Unstable Sequence Regions 4/21/2021

   Ensuring consistent replication and proper retention of plasmid DNA sequence is vital to the economics and efficiency in generating starting materials used for production of AAV delivered gene therapy and mRNA vaccines and therapeutics.

9. Exploring The Spatial Distribution Of mRNA-Lipid Nanoparticles Using MALDI MSI 4/23/2025

   Learn how leveraging high-resolution MALDI-MSI can advance the development of lipid nanoparticle-based therapies, uncovering spatial biodistribution, pharmacokinetics, and organ-specific variability.

10. Advancing RNA-LNP Therapeutics As An Alternative To Viral Vectors 11/17/2025

    RNA-LNP therapeutics offer a flexible, transient alternative to traditional viral vectors for genetic medicine. Learn about the advantages of LNPs in safety, scalability, and payload versatility.