RNA Analytical Quality/Resources

1. IR Spectral Signatures Of GC, AU, And GU Base Pairing In H2O-Based Buffer By MMS 5/22/2025

   Explore a label-free approach to characterize RNA structure with high sensitivity. See how specific base pair types are resolved, providing a clearer picture of RNA folding.

2. Methods for mRNA Poly(A) Sizing 4/26/2024

   This study used Oxford Nanopore Technologies' Direct RNA Sequencing Kit and obtained successful sizing of poly(A) tail regions. The results are presented in a histogram and table format.

3. Analytics And Bioassays Can Safely Fast-Track mRNA-LNP Drug Development 2/23/2023

   One main mRNA technology challenge is the formulation of delivery systems like lipid nanoparticles (LNPs). Learn about evading impurities in lipids, the future of mRNA-based genomic medicines, and more.

4. High-Sensitivity IVT mRNA Analysis 2/20/2025

   Quality analysis of in vitro transcribed (IVT) has become an essential part of biotherapeutic workflows. Discover a high-sensitivity kit made for analyzing IVT mRNA quality to advance your research.

5. Gene Therapy And Oligonucleotide Compendium 1/25/2022

   Technical summaries and detailed protocols for purity testing, sizing, sequencing and expression analysis of oligonucleotide-based active agents as well as protein and lipid-based delivery systems.

6. Targeted LC-MS/MS Detection Of Lipid Impurities In Lipid Nanoparticles 12/9/2024

   Learn about an HPLC-MS/MS method for detecting lipid impurities in lipid nanoparticles (LNPs) and why it is critical for quality control of LNP-based drug delivery systems.

7. Exploring Osmolality As A CQA Within RNA Therapeutics 10/3/2023

   Discover how osmolality can be applied throughout the bioprocessing workflow for RNA, and recognize the importance of this sensitive measurement, from formulation optimization to cryopreservation techniques.

8. Extending The Lower Limits Of Quantification Of A Therapeutic Oligonucleotide Through Microflow LC-MS/MS 3/4/2022

   Here a solution is presented to widely recognized challenges with ionpairing reversed phase liquid chromatography (IP-RP LC) through a novel microflow LC-MS strategy.

9. Expression Analysis Of CTLA-4, PD-1, And PD-L1 4/23/2025

   Advance personalized immunotherapy in NSCLC by leveraging qPCR-based analysis of CTLA-4, PD-1, and PD-L1 expression to identify predictive biomarkers and guide more effective treatment strategies.

10. The Next Generation Of mRNA Products: Implications For Quality Control 5/30/2024

    To fully realize the potential of mRNA as a therapeutic or vaccine modality, developers will need to employ cutting-edge analytical methods to ensure the safety and efficacy of these novel products.