RNA Analytical Quality/Resources

  1. Demystifying CRISPR gRNA Chemical Modifications 10/28/2024

    Chemical modifications on CRISPR gRNAs enhance stability, editing efficiency, and reduce immune responses, enabling in vivo applications and clinical success.

  2. Potent Immune Response With Vernal's LNP-mRNAs 4/26/2024

    As mRNA medicine continues to evolve, understand how trusted manufacturing partners will continue to play a pivotal role in translating innovative concepts into clinical reality.

  3. Gene Therapy And Oligonucleotide Compendium 1/25/2022

    Technical summaries and detailed protocols for purity testing, sizing, sequencing and expression analysis of oligonucleotide-based active agents as well as protein and lipid-based delivery systems.

  4. Expression Analysis Of CTLA-4, PD-1, And PD-L1 4/23/2025

    Advance personalized immunotherapy in NSCLC by leveraging qPCR-based analysis of CTLA-4, PD-1, and PD-L1 expression to identify predictive biomarkers and guide more effective treatment strategies.

  5. Sequencing Of Synthetic Oligonucleotides And Their Impurities 9/20/2022

    We demonstrate an automated, compliance-ready liquid chromatography-mass spectrometry (LC-MS) workflow for sequence confirmation of oligonucleotides and their impurities.

  6. Pre-Banking And Avoiding Manufacturing Challenges For GMP Plasmids Containing Unstable Sequence Regions 4/21/2021

    Ensuring consistent replication and proper retention of plasmid DNA sequence is vital to the economics and efficiency in generating starting materials used for production of AAV delivered gene therapy and mRNA vaccines and therapeutics.

  7. The Future Of Small And Large Molecule Bioanalytics 3/20/2023

    Learn how innovative, emerging technologies are revolutionizing the field of bioanalytics and drug development.

  8. RNA Biotherapeutics — A New Approach To An Old Problem 2/22/2023

    Check out a brief history of RNA-based therapy and how Droplet Digital™ PCR supports this field of work.

  9. Quality Assurance In IVT RNA Vaccine Development Using Electrophoresis 2/20/2025

    Discover advanced solutions for IVT RNA synthesis, focusing on enhancing fidelity in throughput, innovative technologies, and methodologies to optimize your RNA research and development processes.

  10. Quality Control Of Oligonucleotides Using HPLC Coupled To UV And MS Detection 12/6/2024

    Efficient quality control of therapeutic oligonucleotides is crucial. Explore advanced methods combining HPLC-UV and mass spectrometry for precise impurity quantification and mass confirmation.