RNA - The Next Era In Therapeutic Development

RNAs are a relatively new class of therapeutic molecules that have made huge advancements in recent decades and offer hope to reach what were previously considered undruggable targets. RNAs can be used to provide a sequence-specific modulation of gene expression to cause a desired biological response with a beneficial health outcome. They come with their own set of challenges through development and production though, including the need for sufficient stability in vivo due to their inherent instability. However, multiple strategies have been developed for RNA protection, transport, and delivery to the intended target.

Therapeutic RNAs provide a space that's poised to continue growing in the coming years. The application of well-chosen assays, including ddPCR technology–based assays, will support the development and production of safe and effective RNA-based therapeutics. Review the unique set of challenges that must be considered and ultimately solved to reach the full potential of RNA production.