RNA Analytical Quality/Resources

  1. Analytics And Bioassays Can Safely Fast-Track mRNA-LNP Drug Development 2/23/2023

    One main mRNA technology challenge is the formulation of delivery systems like lipid nanoparticles (LNPs). Learn about evading impurities in lipids, the future of mRNA-based genomic medicines, and more.

  2. High-Sensitivity IVT mRNA Analysis 2/20/2025

    Quality analysis of in vitro transcribed (IVT) has become an essential part of biotherapeutic workflows. Discover a high-sensitivity kit made for analyzing IVT mRNA quality to advance your research.

  3. How To Navigate Through The Jungle Of Columns? 12/15/2025

    Whether prioritizing mass spectrometry compatibility or loading capacity, understanding the specific trade-offs between IP-RP, AEX, and SEC methodologies is essential for successful characterization.

  4. Establishing Analytical Methods For mRNA-Based Therapies 6/13/2023

    Here, we provide a detailed description of assays for sequence identification and LNP composition in mRNA-LNP products that support the development of safe and effective mRNA therapies.

  5. Charged For Action: The Hidden Secrets Of AEX Oligonucleotide Analysis 12/15/2025

    Understanding how to fine-tune pH and ionic strength allows for the detection of truncated sequences and single-nucleotide variants, turning complex purification challenges into reproducible data.

  6. Nanomedicine Modalities Find Path To Clinic Through Analytics 5/16/2025

    Lipid nanoparticles have revolutionized drug delivery, ushering in a new era of nanomedicine. Discover how advanced analytical tools are accelerating next-generation LNP therapeutics.

  7. Extending The Lower Limits Of Quantification Of A Therapeutic Oligonucleotide Through Microflow LC-MS/MS 3/4/2022

    Here a solution is presented to widely recognized challenges with ionpairing reversed phase liquid chromatography (IP-RP LC) through a novel microflow LC-MS strategy.

  8. Metabolite ID And Relative Quantification Of Oligonucleotides In Plasma 3/4/2022

    This technical note describes the identification, relative quantification, and structural confirmation of the chain-shortened metabolites of a phosphorothioated oligonucleotide.

  9. From Data To Decisions: Accelerating Your mRNA Drug Development With Analytics 11/20/2024

    To stay ahead in the competitive landscape of mRNA development, adopt a comprehensive QC strategy today and begin conducting meaningful tests to ensure the quality of your test articles.

  10. Future-Proofing mRNA Drug Manufacturing: The Value of Continuous Improvement 4/30/2024

    With so many uncertainties permeating the mRNA market, this largely preclinical industry is still seeking answers on how to reach successful therapeutic development. Identifying optimizations, both sequence-dependent and otherwise, to enhance the manufacturing process is crucial for advancing mRNA product development, which holds vast potential to address a wide range of indications.