RNA Analytical Quality/Resources

  1. Quality Control Of Oligonucleotides Using HPLC Coupled To UV And MS Detection 12/6/2024

    Efficient quality control of therapeutic oligonucleotides is crucial. Explore advanced methods combining HPLC-UV and mass spectrometry for precise impurity quantification and mass confirmation.

  2. Comparing Real-Time And Digital PCR Technologies 6/20/2024

    Which PCR technologies are the most effective? Compare digital PCR (dPCR) and real-time or quantitative PCR (qPCR) to determine the best choice for your labs.

  3. Assigning IR Absorption Bands For RNA Building Blocks Using Microfluidic Modulation Spectroscopy 1/13/2025

    Explore the power of MMS in identifying RNA base signatures. This study analyzes vibrational modes of A, G, C, and U, revealing insights into electronic environments and molecular interactions.

  4. The Hitchhiker´s Guide To Creating Oligonucleotides From Start To Finish 12/15/2025

    Producing high-quality oligonucleotides demands precise execution across multiple stages. Gain a clearer understanding of the complete mid-scale production workflow and necessary quality control measures.

  5. Lentiviral Vector Characterization For Cell And Gene Therapy Manufacturing 6/20/2024

    This study focuses on characterizing recombinant LVVs used in gene-modified cell therapies, utilizing two real-time PCR assays adapted to the QuantStudio™ Absolute Q™ Digital PCR System.

  6. Streamlining The Importing & Exporting Of Biological Samples 9/1/2024

    Create a seamless and predictable import and export process by working with experienced bioanalytical laboratory partners, understanding what paperwork samples require, and proactive planning.

  7. Selection And Evaluation Of Hybridization Capture Probes For LC/MS Analysis Of Oligonucleotides 4/23/2025

    To overcome challenges in oligonucleotide LC/MS bioanalysis, consider optimizing probe design by evaluating alternative chemistries like PNA for improved recovery and chromatographic performance.

  8. A Risk-Based Approach To Plasmid DNA And mRNA Process Development 9/23/2025

    Balancing robust analytics and clinical readiness is key for early-phase pDNA and mRNA therapeutics amid structural complexity and regulatory challenges.

  9. Advancing Genomic Discoveries With Comprehensive Sequencing Support 3/4/2026

    See how a leading genomics facility advances long‑read sequencing through rigorous QC and flexible workflows, offering practical insights for researchers aiming to improve sequencing outcomes.

  10. Assessing Doggybone DNA For In Vitro Transcription 4/26/2024

    In this study, we evaluated the performance of two dbDNA IVT templates, each encoding the same mRNA (firefly luciferase or Fluc), by looking at the mRNA purity and in vivo potency of the mRNA IVT’d from each template.