RNA Analytical Quality/Resources

  1. Methods for mRNA Poly(A) Sizing 4/26/2024

    This study used Oxford Nanopore Technologies' Direct RNA Sequencing Kit and obtained successful sizing of poly(A) tail regions. The results are presented in a histogram and table format.

  2. Effects Of mRNA Capping Technologies 4/26/2024

    This study compares two important mRNA capping technologies by evaluating the mRNA integrity, percent Cap1 content, dsRNA content, in vivo expression, and innate immune activation in mice.

  3. A&M STABTEST Expands Service Offerings In Protein And Oligonucleotide Analysis With LC-MS System 2/22/2022

    CRO upgrades systems to provide regulatory compliance for large-molecule protein analysis, expanding their oligonucleotides capabilities.

  4. Five Essentials For Accurate Oligonucleotide Chemistry 3/4/2024

    Explore five key areas in oligonucleotide chemistry where improvements will have a huge influence on your synthesis quality.

  5. Pre-Banking And Avoiding Manufacturing Challenges For GMP Plasmids Containing Unstable Sequence Regions 4/21/2021

    Ensuring consistent replication and proper retention of plasmid DNA sequence is vital to the economics and efficiency in generating starting materials used for production of AAV delivered gene therapy and mRNA vaccines and therapeutics.

  6. Probing RNA Base Pairing And Ligand Interactions In Solution With Infrared-Based MMS 2/21/2025

    Discover why Microfluidic Modulation Spectroscopy (MMS) is a novel, label-free, solution-based infrared technique for probing RNA base pairing and ligand interactions.

  7. Metabolite ID And Relative Quantification Of Oligonucleotides In Plasma 3/4/2022

    This technical note describes the identification, relative quantification, and structural confirmation of the chain-shortened metabolites of a phosphorothioated oligonucleotide.

  8. Targeted LC-MS/MS Detection Of Lipid Impurities In Lipid Nanoparticles 12/9/2024

    Learn about an HPLC-MS/MS method for detecting lipid impurities in lipid nanoparticles (LNPs) and why it is critical for quality control of LNP-based drug delivery systems.

  9. The Future Of Small And Large Molecule Bioanalytics 3/20/2023

    Learn how innovative, emerging technologies are revolutionizing the field of bioanalytics and drug development.

  10. Biopharma Production And Quality Control With Electrophoresis 2/20/2025

    Discover how Kaneka Eurogentec, a leading provider of custom DNA synthesis and molecular biology service, enhanced their fragment analysis to achieve higher efficiency and accuracy in their workflows.