RNA Analytical Quality/Resources

  1. Comparison Of Constant- And PulsedField Electrophoresis 3/4/2026

    Accurate sizing of large DNA fragments is crucial in long‑read sequencing. Examine how different electrophoresis methods perform with 10–20 kb smears and how to choose the most reliable approach.

  2. Why RNA Diversity Is Raising The Bar For Platform-Aware IVT Design 7/29/2026

    RNA therapeutics now span multiple construct types, each placing distinct demands on in vitro transcription design. Platform-aware IVT thinking is becoming essential as workflows grow more complex.

  3. 5 Key Questions On How To Accelerate mRNA Development 4/20/2026

    Stakeholders are working to solve key mRNA manufacturing challenges, including how raw materials impact product quality and how to address scale up. Though existing analytical and manufacturing technologies may fall short for mRNA, investment in innovative techniques will help meet increasing demand for personalized therapeutics.

  4. Sequencing Of Synthetic Oligonucleotides And Their Impurities 9/20/2022

    We demonstrate an automated, compliance-ready liquid chromatography-mass spectrometry (LC-MS) workflow for sequence confirmation of oligonucleotides and their impurities.

  5. 5 IVT Design Considerations Before Scale-Up 7/29/2026

    As RNA programs advance toward clinical manufacturing, five IVT design questions can help teams identify hidden process risks before scale-up exposes them.

  6. Oligonucleotides: Where We Are And Where We Would Like To Go  9/8/2024

    This presentation provides an overview of oligonucleotide bioanalysis's current status and future directions. We will look into the advantages and disadvantages of various bioanalytical techniques.

  7. Suitability Testing For IVT mRNA Analysis 11/20/2025

    Automated capillary electrophoresis provides robust, precise analysis of IVT mRNA integrity, concentration, and size, demonstrating excellent method precision.

  8. Optimizing mRNA For Success: A Guide To Enhanced Stability, Delivery, And Efficacy 6/11/2024

    RNA offers exciting potential for vaccines, gene therapies, and personalized medicine, but challenges related to stability, delivery, and manufacturing persist.

  9. Comprehensive Characterization Of Oligonucleotides And Related Impurities 7/29/2026

    A two-dimensional LC/MS strategy improves the separation of coeluting oligonucleotide impurities. High-resolution sampling and automation enable deeper characterization of low-level variants.

  10. Advancing Genomic Discoveries With Comprehensive Sequencing Support 3/4/2026

    See how a leading genomics facility advances long‑read sequencing through rigorous QC and flexible workflows, offering practical insights for researchers aiming to improve sequencing outcomes.