RNA Analytical Quality/Resources

  1. Alternatives To CRISPR-Cas9: Nucleases For Next-Gen Therapy 10/28/2024

    Alternatives to CRISPR-Cas9 address limitations like delivery challenges and off-target effects. Emerging nucleases offer improved specificity, smaller sizes, and therapeutic applications.

  2. Unlocking The IP Benefits Of Novel Nucleases In CRISPR Therapies 10/28/2024

    Incorporating novel nucleases into CRISPR therapies enhances intellectual property benefits through improved licensing, strategic protections, and access to new gene targets.

  3. Analyzing Poly(A) Tails Of In Vitro Transcribed RNA 11/20/2025

    Find out how to achieve reliable IVT mRNA quality. Learn the best practices for precise analysis, including proper sample prep and system optimization for high-resolution results.

  4. Exploring Osmolality As A CQA Within RNA Therapeutics 10/3/2023

    Discover how osmolality can be applied throughout the bioprocessing workflow for RNA, and recognize the importance of this sensitive measurement, from formulation optimization to cryopreservation techniques.

  5. Demystifying CRISPR gRNA Chemical Modifications 10/28/2024

    Chemical modifications on CRISPR gRNAs enhance stability, editing efficiency, and reduce immune responses, enabling in vivo applications and clinical success.

  6. Establishing Analytical Methods For mRNA-Based Therapies 6/13/2023

    Here, we provide a detailed description of assays for sequence identification and LNP composition in mRNA-LNP products that support the development of safe and effective mRNA therapies.

  7. dsRNA: Why Polymerase Choice Matters 3/17/2026

    Polymerase selection during IVT shapes dsRNA levels, processing costs, and product quality. See how enzyme engineering reduces abortive transcripts and improves purity profiles for complex mRNA manufacturing applications.

  8. Size Matters: Mastering Size Exclusion For Oligos 12/15/2025

    Learn how to separate molecules strictly by size, effectively remove salts, and select the correct pore specifications for a gentle, non-destructive purification workflow.

  9. A&M STABTEST Expands Service Offerings In Protein And Oligonucleotide Analysis With LC-MS System 2/22/2022

    CRO upgrades systems to provide regulatory compliance for large-molecule protein analysis, expanding their oligonucleotides capabilities.

  10. Enabling Effective Passive And Active Immune Cell Targeting Strategies 8/10/2026

    Targeted LNPs that bypass the liver and home to the spleen could reshape in vivo CAR T cell manufacturing. See the data behind the approach.