RNA Analytical Quality/Resources

  1. Exploring The Spatial Distribution Of mRNA-Lipid Nanoparticles Using MALDI MSI 4/23/2025

    Learn how leveraging high-resolution MALDI-MSI can advance the development of lipid nanoparticle-based therapies, uncovering spatial biodistribution, pharmacokinetics, and organ-specific variability.

  2. Future-Proofing mRNA Drug Manufacturing: The Value of Continuous Improvement 4/30/2024

    With so many uncertainties permeating the mRNA market, this largely preclinical industry is still seeking answers on how to reach successful therapeutic development. Identifying optimizations, both sequence-dependent and otherwise, to enhance the manufacturing process is crucial for advancing mRNA product development, which holds vast potential to address a wide range of indications.

  3. Assigning IR Absorption Bands For RNA Building Blocks Using Microfluidic Modulation Spectroscopy 1/13/2025

    Explore the power of MMS in identifying RNA base signatures. This study analyzes vibrational modes of A, G, C, and U, revealing insights into electronic environments and molecular interactions.

  4. Top 5 Approaches To The Bioanalysis Of Oligonucleotides 9/1/2024

    Evaluate the strengths and limitations of each bioanalysis method carefully to choose the most effective strategy for your clinical study.

  5. Study Viral Infection In Resting Human CD4+ T Cells 11/28/2023

    Explore a study proving how synthetic single guide RNAs were used to optimize the editing conditions for resting human CD4+ T cells and maintain high cell viability for several weeks post Nucleofection.

  6. Mastering mRNA Manufacturing: A Focus on Raw Materials & Supply Assurance 10/23/2024

    Rapid advancements in mRNA-based therapeutic development have underscored the role of raw material quality and supply chain management in ensuring their successful production.

  7. Establishing Analytical Methods For mRNA-Based Therapies 6/13/2023

    Here, we provide a detailed description of assays for sequence identification and LNP composition in mRNA-LNP products that support the development of safe and effective mRNA therapies.

  8. The Future Of Small And Large Molecule Bioanalytics 3/20/2023

    Learn how innovative, emerging technologies are revolutionizing the field of bioanalytics and drug development.

  9. Data Processing For Mass Confirmation, Impurities Analysis Of Oligos 5/5/2022

    Explore an automated, compliance-ready LC-MS workflow for intact mass confirmation and purity analysis of synthetic oligonucleotides including siRNA and large single guide RNA oligonucleotides.

  10. Structural Characterization Of RNA And Detection Of RNA-Ligand Binding 1/13/2025

    Delve into the intricacies of riboswitch behavior and ligand interactions and gain valuable insights into gene regulation and potential therapeutic targets.