RNA Analytical Quality/Resources

31. How To Navigate Through The Jungle Of Columns? 12/15/2025

    Whether prioritizing mass spectrometry compatibility or loading capacity, understanding the specific trade-offs between IP-RP, AEX, and SEC methodologies is essential for successful characterization.

32. The Absolute Essentials Of Manufacturability 11/12/2025

    Learn why integrating Quality by Design (QbD) and Process Analytical Technology (PAT) early on is essential for developing a robust, controlled, and financially viable process.

33. A Risk-Based Approach To Plasmid DNA And mRNA Process Development 9/23/2025

    Balancing robust analytics and clinical readiness is key for early-phase pDNA and mRNA therapeutics amid structural complexity and regulatory challenges.

34. Extending The Lower Limits Of Quantification Of A Therapeutic Oligonucleotide Through Microflow LC-MS/MS 3/4/2022

    Here a solution is presented to widely recognized challenges with ionpairing reversed phase liquid chromatography (IP-RP LC) through a novel microflow LC-MS strategy.

35. Lipid Nanoparticle Compositional Analysis By UHPLC-CAD 6/30/2023

    Explore results generated from an internal study using a proprietary mRNA-LNP formulation and UHPLC-CAD, a powerful technique for the analysis of compounds that do not contain chromophores.

36. Understanding The Intricacies Of qMSI 9/1/2024

    Explore quantitative mass spectrometry imaging (QMSI) and leading spatial bioanalysis and biology services that offers one-on-one support throughout your drug development process.

37. Probing RNA Base Pairing And Ligand Interactions In Solution With Infrared-Based MMS 2/21/2025

    Discover why Microfluidic Modulation Spectroscopy (MMS) is a novel, label-free, solution-based infrared technique for probing RNA base pairing and ligand interactions.

38. Top 5 Approaches To The Bioanalysis Of Oligonucleotides 9/1/2024

    Evaluate the strengths and limitations of each bioanalysis method carefully to choose the most effective strategy for your clinical study.

39. Pre-Banking And Avoiding Manufacturing Challenges For GMP Plasmids Containing Unstable Sequence Regions 4/21/2021

    Ensuring consistent replication and proper retention of plasmid DNA sequence is vital to the economics and efficiency in generating starting materials used for production of AAV delivered gene therapy and mRNA vaccines and therapeutics.

40. The Future Of Small And Large Molecule Bioanalytics 3/20/2023

    Learn how innovative, emerging technologies are revolutionizing the field of bioanalytics and drug development.