RNA Manufacturing Solutions

1. Centrifugal Devices 2/3/2025

   Centrifugal devices can replace traditional separation techniques, such as column chromatography, preparative electrophoresis, alcohol or salt precipitation, dialysis, and gradient centrifugation. Pall’s centrifugal devices simplify many common nucleic acid and protein sample preparation procedures. These devices provide efficient concentration and salt removal of samples from 50 μL to 60 mL in just minutes.

2. mRNA/LNP Development And Manufacturing Services

   Messenger RNAs (mRNAs) represent a fast-emerging class of biotherapeutics. In recent years, we at Lonza have amassed considerable expertise in the commercial manufacturing of mRNA and its encapsulation in Lipid Nanoparticles (LNP) at cGMP quality.

3. A Single-Use Chromatography System For Scale-Up And GMP Manufacturing 5/13/2024

   ÄKTA ready™ is a single-use liquid chromatography system built for process scale-up and GMP manufacturing. The single-use flow path minimizes the need for cleaning and cleaning validation, allowing for quick changeover between productions and reducing the risk of carryover. The ÄKTA ready chromatography system offers the performance and documentation required for use in a GMP-regulated environment.

4. Plasmid DNA Production 6/23/2022

   Integrated manufacturing supporting cell and gene therapies.

   The critical genetic foundation for advanced therapies

   Plasmid DNA is a critical raw material for advanced therapies and mRNA synthesis, supporting their transfection to enable rapid advancement of the therapeutic product. Center for Breakthrough Medicines (CBM) offers capacity dedicated to the development and manufacture of high quality plasmid DNA and other nucleic acids.

5. Phosphitylating And Phosphorylating Agents 11/25/2025

   Explore essential phosphitylating and phosphorylating agents used in API synthesis and oligonucleotide preparation for cell and gene therapy applications.

6. A Gloveless Aseptic Filling System For Vials, Syringes, And Cartridges 3/23/2023

   A gloveless system that reduces risk for flexible vial, syringe, and cartridge filling.

7. Fit-For-Purpose And GMP Grade mRNA Reagents 3/24/2025

   Ensure the safety and efficacy of your mRNA therapeutics with high-quality, GMP-grade reagents from a trusted partner with a multi-tiered quality approach to deliver manufacturing certainty.

8. Bioproduction Analytical Services 10/29/2024

   Optimize your cell culture media performance with comprehensive bioproduction analytical solutions. Advanced technology and expert consultation result in actionable insights for improved production outcomes.

9. GenVoy-ILM™ T-Cell Kits For mRNA 4/24/2025

   Off-the-shelf, research use only lipid nanoparticle (LNP) reagents to deliver RNA into T-cells.

10. Metabolite And Lipid Analysis Service 10/29/2024

    Unlock actionable insights into your cell culture process with metabolite and lipid analysis, enabling data-driven optimizations for growth, titer, and product quality.