RNA Manufacturing Resources

1. mRNA/saRNA Manufacturing RNA Analytics And Testing 5/24/2023

   Venkata Indurthi, Ph.D., shares his knowledge and experience with manufacturing RNA, including key downstream considerations for RNA characterization and purity and how optimization can result in more efficient dosing.

2. Where Can Novel Non-Viral Polymeric Delivery Agents Take Us? 1/18/2023

   Explore ongoing work to harness different types of HDR templates in order to build cutting-edge systems with the potential to enable point-of-care cell and gene therapy manufacture.

3. mRNA Product Purification Process Strategies 2/15/2023

   Impurities from IVT can induce undesired immune responses and negatively impact translation efficiency. Explore the pros and cons of each option for mRNA purification.

4. Downstream Process Development For Efficient Purification Of Adenovirus 9/10/2018

   Here, we describe the development of two effective downstream processes for purification of adenovirus from cell culture harvest.

5. Understanding The Hidden Value Of Quality 6/26/2023

   Costs of poor quality (COPQ) cannot be overstated. Review the statistics that prove how costly it can be to avoid resolving quality issues in your processes and supply chain.

6. Separation Of cfDNA With An NGS Kit On Fragment Analyzer Systems 3/19/2026

   Learn how precise sizing methods reveal nucleosome patterns in cfDNA and help distinguish true signal from extraction‑related artifacts for more reliable genomic analysis.

7. The Chilled Future Of mRNA Filling And Freezing 4/17/2023

   Manufacturers at biotech and biopharma companies need help keeping up with continuously advancing novel treatments. Technologies that provide control over the freeze-thaw process offer solutions.

8. Optimization Of Transient Transfection Of MSCs With Plasmid DNA Or mRNA 11/1/2022

   Read through the results of our efforts to produce an optimal protocol for the transient transfection of hMSCs with pDNA or mRNA using non-viral means.

9. The Future Is Now: CGT Innovation, Challenges, And Perspectives 7/19/2023

   As CGTs advance toward clinical trials, developers face a number of challenges such as navigating a shifting regulatory landscape and employing beneficial manufacturing processes.

10. Key Insights Into Overcoming mRNA Process Challenges 9/8/2021

    Realizing the potential of mRNA requires focus on key areas and strategies that could help alleviate the bottlenecks in this growing market segment.