RNA Manufacturing Resources

1. LNP Formulation For mRNA Delivery 2/15/2023

   Microfluidic mixing is one of the most effective means to formulate LNPs for its scalability and reproducibility. Explore LNP formulation, polishing, sterile filtration of mRNA-LNPs, and more.

2. Fast And Efficient Extraction Of mRNA From IVT Mixtures 6/7/2021

   Here, a fast and efficient way to purify polyadenylated mRNA using affinity chromatography on the CIMmultus® Oligo dT column is presented.

3. Comprehensive Characterization Of Oligonucleotides And Related Impurities 7/29/2026

   A two-dimensional LC/MS strategy improves the separation of coeluting oligonucleotide impurities. High-resolution sampling and automation enable deeper characterization of low-level variants.

4. Key Topics And Trends In Aseptic Filling 1/9/2026

   Aseptic filling is vital yet often guided by outdated practices. Discover expert insights on modern technologies, evolving regulations, and data-driven strategies to improve compliance and reduce risk in this critical manufacturing step.

5. The Pivotal Role Of Plasmid DNA 1/13/2021

   Today, plasmid DNA plays a critical role in the production of next-generation cell and gene therapies and vaccines. With our plasmid DNA manufacturing expertise, we have helped facilitate the advance of these important therapeutics.

6. How To Navigate Through The Jungle Of Columns? 12/15/2025

   Whether prioritizing mass spectrometry compatibility or loading capacity, understanding the specific trade-offs between IP-RP, AEX, and SEC methodologies is essential for successful characterization.

7. The Sponsor's Clinical Development Handbook For Gene Therapy Trials 6/21/2024

   Gene therapy has existed for decades, but the field is not as mature as it may seem. Here, the author provides essential insights and strategies for overcoming gene therapy development challenges.

8. Purifying Plasmid DNA Using A Modern Chromatography Resin 2/5/2020

   Through an industry collaboration, Cobra and Cytiva were able to combine their expertise and experience and create a solution to meet the rising demand for high quality plasmid DNA.

9. Safe, Scalable And GMP-Ready DNA 4/24/2026

   Cell‑free synthetic DNA provides a scalable, safer alternative to plasmids by eliminating bacterial risks, simplifying quality control, and enabling complex sequences under GMP‑aligned conditions.

10. Simultaneous Extraction Of Mycoplasma, MMV, And Vesivirus Nucleic Acids From A Single Sample 6/7/2024

    Achieve early detection of cell culture contamination with a nucleic acid extraction system to provide an integrated system for rapid and sensitive detection of mycoplasma, MMV, and vesivirus.