RNA Manufacturing Resources

1. xRNA Production: The Economic Case For Continuous Manufacturing 10/31/2025

   See how a continuous manufacturing platform streamlines production to days, uses real-time quality control, and dramatically cuts costs to accelerate access to new therapies.

2. 4 Steps Toward End-To-End Connected Manufacturing 7/25/2019

   Breaking down the implementation of continuous manufacturing into the following four steps may provide some much-needed guidance as you prepare your network for the future of biomanufacturing.

3. mRNA-LNP Nucleic Acid Assessment From Distinct Formulations 9/8/2023

   Review a showcase of a high throughput robust analysis for nucleic acid integrity and size assessment of mRNA-LNP samples using a multi-capillary system and purity and integrity analysis kit.

4. Fast And Efficient Extraction Of mRNA From IVT Mixtures 6/7/2021

   Here, a fast and efficient way to purify polyadenylated mRNA using affinity chromatography on the CIMmultus® Oligo dT column is presented.

5. When Local Variation Becomes Global Risk In Phase III 8/3/2026

   Late-stage therapy trials demand strict execution. Learn how local handling variations escalate into global risks and how early standardization safeguards therapeutic integrity and compliance.

6. Optimization Of Transient Transfection Of MSCs With Plasmid DNA Or mRNA 11/1/2022

   Read through the results of our efforts to produce an optimal protocol for the transient transfection of hMSCs with pDNA or mRNA using non-viral means.

7. Oligonucleotide Development And Manufacturing Workflow 3/28/2022

   Learn more about oligo workflows and solutions for oligonucleotide process development, from scalable oligo synthesis to cleavage and deprotection, purification, and buffer exchange.

8. Digital Twins And Mechanistic Models For Optimized Bioprocessing 3/24/2025

   Integrating AI and having a robust IT infrastructure is crucial for modernizing your processes. Discover how digital twins and mechanistic modeling are revolutionizing biomanufacturing, enhancing efficiency, and reducing costs.

9. From LNP Delivery To Functional CAR-T: Rethinking Targeting 10/16/2026

   Optimizing LNPs for in vivo CAR-T requires aligning target selection, formulation design, and delivery performance to achieve functional CAR expression in desired T-cell populations while balancing specificity, safety, dosing flexibility, and manufacturability.

10. How To Automate Continued Process Verification

    This eBook describes automation of continued process verification and offers a one-click solution for statistical trending of data, campaign reports, and annual product quality review.