RNA Manufacturing Resources

1. How To Choose The Correct Syringe Filter For Analytical Sample Preparation 4/28/2022

   This paper simplifies syringe filter selection and reviews the membranes and sizes required for specific analytical applications.

2. Leveraging Single-Use Technology For mRNA-LNP Drug Manufacturing 6/12/2023

   Single-use technology is vital for ensuring the quality and expedited market entry of genomic medicines. Learn how LNP technology is paving the way for a new era of personalized, precise medicine.

3. Essential Strategies For IVT Optimization 11/21/2024

   Optimizing in vitro transcription (IVT) for mRNA is crucial to improving the stability of these molecules and enabling their large-scale production.

4. Discussing mRNA: Challenges And Opportunities For Scale-Out And Optimization 2/6/2024

   In a recent Cell & Gene Live event, experts explored challenges surrounding raw materials – both quality and supply – as well as the importance of achieving more efficient scale-out and turnaround times for mRNA production.

5. mRNA-LNP Nucleic Acid Assessment From Distinct Formulations 9/8/2023

   Review a showcase of a high throughput robust analysis for nucleic acid integrity and size assessment of mRNA-LNP samples using a multi-capillary system and purity and integrity analysis kit.

6. Digital Biomanufacturing, Now: From Digital Dreamer To Digital Doer 3/24/2025

   Discover how digital biomanufacturing is revolutionizing drug production by exploring strategies for integrating digital technologies to enhance efficiency, reliability, and innovation in bioprocessing workflows.

7. In-Process Control Of pDNA Production On CIMac™ pDNA Analytical Column 6/10/2021

   As the demand for plasmid DNA (pDNA) based gene therapy and vaccines increases, large-scale, cost-effective, and reproducible pDNA production is required. The key to success is a real-time in-process control method that ensures a high percentage of supercoiled pDNA in the final product. Read how the CIMac™ pDNA Analytical Column allows the monitoring of degradation products (open circular and linear pDNA), the removal of impurities (RNA), and ensures that each production step yields the amount of supercoiled pDNA anticipated.

8. Modeling The Economics Of Vaccine Manufacturing 5/26/2023

   Here, we describe the use of a custom-designed cost model to explore the economics of vaccine manufacturing when using different modalities.

9. DNA Purification From PCR Or Agarose Gels 4/28/2022

   This study assesses the use of NAB Nanosep centrifugal devices with commercially available reagents for PCR or agarose gel cleanup.

10. Expanding Into New Fields Of “Cell-Grow-Culture” For mRNA Transfection 1/13/2023

    Learn about one path forward to navigate the pitfalls with mRNA transfection and a medium to assist in lentivirus-mediated transduction of human mesenchymal stromal/stem cells (hMSCs).