RNA Manufacturing Articles

1. The Hidden Bottleneck In Advanced Therapies Isn't Science… It's Translational Friction 6/26/2026

   Scientific breakthroughs may spark innovation, but operational excellence ultimately determines which advanced therapies reach patients.

2. RNA Therapeutics: Why CMC Strategy Will Define The Next Decade 6/25/2026

   As RNA matures into an industrial platform, long-term success will depend less on discovery and more on scalable CMC systems, integration, and execution.

3. Rethinking The Oligonucleotide Backbone: Why RNA Therapeutics May Need A New Molecular Design Framework 6/24/2026

   New backbone chemistries could unlock greater control over delivery, specificity, and safety, expanding the molecular design space for RNA medicines.

4. RNA Platforms: What Transfers And What Breaks 6/23/2026

   A practical framework for distinguishing reusable RNA platform knowledge from biology-specific unknowns as therapeutics expand into new tissues and indications.

5. Stay "Stereocurious": What The Future Holds For Oligo Quality 6/22/2026

   Overall, there were two areas of discussion at TIDES that demonstrate the amount of growth we have yet to do as a space — particularly in the realms of regulatory development and quality. As I intend to showcase here in part 1 of this muti-part article, this year’s TIDES was a great reflection of the tension(s) that can arise as we realize how much space exists between where we are and where we’re going next. 

6. Scaling RNA Therapeutics: Purification, LNP Formulation, And GMP Manufacturing (Pt. 2) 6/4/2026

   Part 2 explores the downstream technologies that turn RNA into a therapeutic product, from impurity removal and LNP formulation to GMP infrastructure and scalable manufacturing.

7. What Makes An RNA Platform Investable? Lessons From The Last Wave Of Biotech Financing 5/28/2026

   RNA investing has shifted from hype to scalability, forcing companies to prove manufacturability, delivery strength, and platform-wide value.

8. RNA Manufacturing Foundations: From DNA Templates To In Vitro Transcription (Pt. 1) 5/27/2026

   Cell-free RNA production is reshaping biomanufacturing through modular IVT workflows, advanced capping strategies, and scalable DNA template design.

9. Engineering RNA Payload Distribution In LNPs To Unlock Higher In Vivo Gene Editing Efficiency 5/22/2026

   New research shows RNA payload distribution inside LNPs — not just encapsulation efficiency — may be key to unlocking stronger in vivo gene editing performance.

10. RNA Modification-Mediated Translational Control In Immune Cells 5/20/2026

    Exploring how m6A RNA modifications control immune cell translation, influencing inflammation, tumor immunity, T cell activation, and future immunotherapies.