Mitigate Contamination Risks With HTST Flash Pasteurization
Gibco™ High-temperature, short-time (HTST) treatment of raw materials
HTST treatment currently available in North America
Simple sugar batch sizes ranging from 800 to 8,800 L
In-house HTST preparation can be expensive and cumbersome. Outsourcing this technology to Thermo Fisher Scientific can alleviate production bottlenecks and increase viral mitigation confidence.
Suitable and cost-effective for large volumes
Standard and custom bioprocessing containers available (5 L–1,000 L). Please contact your sales representative.
Proactively help protect your cell culture investment
Gibco™ high-temperature, short time (HTST) treatment is an in-line pasteurization technology. It offers a risk mitigation step to prevent potential viral contaminations from entering upstream manufacturing.
The HTST process uses heat (100°C+) to inactivate any potential virus present in the raw material prior to packaging the product. Products such as glucose and other simple sugars are heated for a brief time period, to not alter the treated product’s performance or viability. Integrating HTST is a critical step in having a comprehensive viral risk-mitigation program.
Proactive prevention
- Risk of contamination of plant-based raw materials exists despite cGMP adherence, animal origin– free and chemically defined raw materials, supplier risk assessment programs, and viral detection technology
- Although infrequent, viral contamination to cell culture nutrients can be a catastrophic event to manufacturing, product and patient safety, sales, and corporate reputation
With the HTST method, high-risk raw materials such as glucose are pasteurized using a high temperature, then rapidly cooled.