RNA Analytical Quality/Resources

1. Advancing RNA-LNP Therapeutics As An Alternative To Viral Vectors 11/17/2025

   RNA-LNP therapeutics offer a flexible, transient alternative to traditional viral vectors for genetic medicine. Learn about the advantages of LNPs in safety, scalability, and payload versatility.

2. Expectations On The Pathway To GMP For Gene-Modified Cell Therapies 6/21/2023

   Learn how a robust understanding of the RNP’s critical process parameters and CQAs is crucial for ensuring product consistency, enhancing patient safety, and maintaining regulatory compliance.

3. The Next Generation Of mRNA Products: Implications For Quality Control 5/30/2024

   To fully realize the potential of mRNA as a therapeutic or vaccine modality, developers will need to employ cutting-edge analytical methods to ensure the safety and efficacy of these novel products.

4. Study Viral Infection In Resting Human CD4+ T Cells 11/28/2023

   Explore a study proving how synthetic single guide RNAs were used to optimize the editing conditions for resting human CD4+ T cells and maintain high cell viability for several weeks post Nucleofection.

5. Data Processing For Mass Confirmation, Impurities Analysis Of Oligos 5/5/2022

   Explore an automated, compliance-ready LC-MS workflow for intact mass confirmation and purity analysis of synthetic oligonucleotides including siRNA and large single guide RNA oligonucleotides.

6. The Hitchhiker´s Guide To Creating Oligonucleotides From Start To Finish 12/15/2025

   Producing high-quality oligonucleotides demands precise execution across multiple stages. Gain a clearer understanding of the complete mid-scale production workflow and necessary quality control measures.

7. The Art Of Phosphitylation 11/24/2025

   Phosphorylation is key for bioactives, with phosphoramidites favored for high selectivity. Discover how choosing specific protecting groups and new technologies fine-tunes the synthesis process.

8. The Future Of Small And Large Molecule Bioanalytics 3/20/2023

   Learn how innovative, emerging technologies are revolutionizing the field of bioanalytics and drug development.

9. Demystifying CRISPR gRNA Chemical Modifications 10/28/2024

   Chemical modifications on CRISPR gRNAs enhance stability, editing efficiency, and reduce immune responses, enabling in vivo applications and clinical success.

10. How To Navigate Through The Jungle Of Columns? 12/15/2025

    Whether prioritizing mass spectrometry compatibility or loading capacity, understanding the specific trade-offs between IP-RP, AEX, and SEC methodologies is essential for successful characterization.