RNA Analytical Quality/Resources

1. Ultra-Sensitive Assay For Anti-Sense Oligonucleotide Quantification 3/1/2022

   Learn about a new level in sensitivity for challenging analytes in matrix that opens doors for accurate bioanalysis and metabolism studies with specificity not achievable with orthogonal methods.

2. Top 8 Benefits Of Mass Spectrometry Imaging Early In Drug Development 9/1/2024

   Here we explore the top 8 benefits of using mass spectrometry imaging in the oncology drug discovery and early development stages.

3. Comparing Real-Time And Digital PCR Technologies 6/20/2024

   Which PCR technologies are the most effective? Compare digital PCR (dPCR) and real-time or quantitative PCR (qPCR) to determine the best choice for your labs.

4. Analytics And Bioassays Can Safely Fast-Track mRNA-LNP Drug Development 2/23/2023

   One main mRNA technology challenge is the formulation of delivery systems like lipid nanoparticles (LNPs). Learn about evading impurities in lipids, the future of mRNA-based genomic medicines, and more.

5. Pushing The Boundaries Of Chromatographic Separation 7/29/2026

   Metal-sensitive analytes often suffer from poor recovery and distorted peak shapes. Learn how inert hardware improves sensitivity and chromatographic performance for challenging analyses.

6. Future-Proofing mRNA Drug Manufacturing: The Value of Continuous Improvement 4/30/2024

   With so many uncertainties permeating the mRNA market, this largely preclinical industry is still seeking answers on how to reach successful therapeutic development. Identifying optimizations, both sequence-dependent and otherwise, to enhance the manufacturing process is crucial for advancing mRNA product development, which holds vast potential to address a wide range of indications.

7. Elevating mRNA Manufacturing Toward GMP-Readiness 8/27/2025

   The mRNA Technology Transfer Program empowers LMICs with scalable vaccine production. Learn about a partnership that drives innovation in mRNA and sets a global blueprint for equitable health access.

8. Lentiviral Vector Characterization For Cell And Gene Therapy Manufacturing 6/20/2024

   This study focuses on characterizing recombinant LVVs used in gene-modified cell therapies, utilizing two real-time PCR assays adapted to the QuantStudio™ Absolute Q™ Digital PCR System.

9. The Next Generation Of mRNA Products: Implications For Quality Control 5/30/2024

   To fully realize the potential of mRNA as a therapeutic or vaccine modality, developers will need to employ cutting-edge analytical methods to ensure the safety and efficacy of these novel products.

10. Unlocking The IP Benefits Of Novel Nucleases In CRISPR Therapies 10/28/2024

    Incorporating novel nucleases into CRISPR therapies enhances intellectual property benefits through improved licensing, strategic protections, and access to new gene targets.