RNA Analytical Quality/Resources

1. Extending The Lower Limits Of Quantification Of A Therapeutic Oligonucleotide Through Microflow LC-MS/MS 3/4/2022

   Here a solution is presented to widely recognized challenges with ionpairing reversed phase liquid chromatography (IP-RP LC) through a novel microflow LC-MS strategy.

2. Large Scale Purification Of Oligonucleotides With IEX 12/6/2024

   As oligonucleotide-based drugs gain momentum in therapeutic development, refining their manufacturing processes through solutions like ion exchange chromatography (IEX) becomes crucial.

3. Best Practices For Analysis Of IVT mRNA 11/20/2025

   Discover how an automated capillary electrophoresis system provides robust and precise integrity, concentration, and size analysis for IVT mRNA.

4. The Evolution Of Nucleotide Production 4/2/2025

   From harsh chemicals to gentle enzymes: Explore the groundbreaking shift in nucleotide synthesis, making drug manufacturing cleaner, greener, and more efficient.

5. Lipid Nanoparticle Compositional Analysis By UHPLC-CAD 6/30/2023

   Explore results generated from an internal study using a proprietary mRNA-LNP formulation and UHPLC-CAD, a powerful technique for the analysis of compounds that do not contain chromophores.

6. High-Throughput Characterization Of RNA 5/9/2022

   How a multi-capillary electrophoresis (CE) system is used to efficiently separate a wide range of RNA-based molecules by size and demonstrates the multiplex capability for RNA characterization.

7. Preventive Control Of Sequencing Through The Insert 3/4/2026

   Understanding library size distributions helps prevent sequencing through the insert, reducing adapter read‑through. Explore how smear analysis guides optimal read‑length selection to avoid noise.

8. Analyzing Poly(A) Tails Of In Vitro Transcribed RNA 11/20/2025

   Find out how to achieve reliable IVT mRNA quality. Learn the best practices for precise analysis, including proper sample prep and system optimization for high-resolution results.

9. Top 5 Approaches To The Bioanalysis Of Oligonucleotides 9/1/2024

   Evaluate the strengths and limitations of each bioanalysis method carefully to choose the most effective strategy for your clinical study.

10. Charged For Action: The Hidden Secrets Of AEX Oligonucleotide Analysis 12/15/2025

    Understanding how to fine-tune pH and ionic strength allows for the detection of truncated sequences and single-nucleotide variants, turning complex purification challenges into reproducible data.