RNA Analytical Quality/Resources

1. Biopharma Production And Quality Control With Electrophoresis 2/20/2025

   Discover how Kaneka Eurogentec, a leading provider of custom DNA synthesis and molecular biology services, enhanced their fragment analysis to achieve higher efficiency and accuracy in their workflows.

2. Pre-Banking And Avoiding Manufacturing Challenges For GMP Plasmids Containing Unstable Sequence Regions 4/21/2021

   Ensuring consistent replication and proper retention of plasmid DNA sequence is vital to the economics and efficiency in generating starting materials used for production of AAV delivered gene therapy and mRNA vaccines and therapeutics.

3. Effects Of mRNA Capping Technologies 4/26/2024

   This study compares two important mRNA capping technologies by evaluating the mRNA integrity, percent Cap1 content, dsRNA content, in vivo expression, and innate immune activation in mice.

4. Establishing Analytical Methods For mRNA-Based Therapies 6/13/2023

   Here, we provide a detailed description of assays for sequence identification and LNP composition in mRNA-LNP products that support the development of safe and effective mRNA therapies.

5. CRISPR Off-Target Editing: Prediction, Analysis, And More 2/28/2025

   A crucial consideration for researchers is off-target editing – unintended DNA modifications at sites other than the intended target. Explore the complexities and strategies to mitigate these effects.

6. Unlocking The IP Benefits Of Novel Nucleases In CRISPR Therapies 10/28/2024

   Incorporating novel nucleases into CRISPR therapies enhances intellectual property benefits through improved licensing, strategic protections, and access to new gene targets.

7. Structural Characterization Of RNA And Detection Of RNA-Ligand Binding 1/13/2025

   Delve into the intricacies of riboswitch behavior and ligand interactions and gain valuable insights into gene regulation and potential therapeutic targets.

8. Probing RNA Base Pairing And Ligand Interactions In Solution With Infrared-Based MMS 2/21/2025

   Discover why Microfluidic Modulation Spectroscopy (MMS) is a novel, label-free, solution-based infrared technique for probing RNA base pairing and ligand interactions.

9. Targeted LC-MS/MS Detection Of Lipid Impurities In Lipid Nanoparticles 12/9/2024

   Learn about an HPLC-MS/MS method for detecting lipid impurities in lipid nanoparticles (LNPs) and why it is critical for quality control of LNP-based drug delivery systems.

10. Expression Analysis Of CTLA-4, PD-1, And PD-L1 4/23/2025

    Advance personalized immunotherapy in NSCLC by leveraging qPCR-based analysis of CTLA-4, PD-1, and PD-L1 expression to identify predictive biomarkers and guide more effective treatment strategies.