RNA Analytical Quality/Resources

1. The Evolution Of Nucleotide Production 4/2/2025

   From harsh chemicals to gentle enzymes: Explore the groundbreaking shift in nucleotide synthesis, making drug manufacturing cleaner, greener, and more efficient.

2. Structural Characterization Of RNA And Detection Of RNA-Ligand Binding 1/13/2025

   Delve into the intricacies of riboswitch behavior and ligand interactions and gain valuable insights into gene regulation and potential therapeutic targets.

3. Five Essentials For Accurate Oligonucleotide Chemistry 3/4/2024

   Explore five key areas in oligonucleotide chemistry where improvements will have a huge influence on your synthesis quality.

4. Gene Therapy And Oligonucleotide Compendium 1/25/2022

   Technical summaries and detailed protocols for purity testing, sizing, sequencing and expression analysis of oligonucleotide-based active agents as well as protein and lipid-based delivery systems.

5. Extending The Lower Limits Of Quantification Of A Therapeutic Oligonucleotide Through Microflow LC-MS/MS 3/4/2022

   Here a solution is presented to widely recognized challenges with ionpairing reversed phase liquid chromatography (IP-RP LC) through a novel microflow LC-MS strategy.

6. Data Processing For Mass Confirmation, Impurities Analysis Of Oligos 5/5/2022

   Explore an automated, compliance-ready LC-MS workflow for intact mass confirmation and purity analysis of synthetic oligonucleotides including siRNA and large single guide RNA oligonucleotides.

7. Nucleases - Are They A Problem For NAB Nanosep® Centrifugal Devices? 4/29/2022

   We examine whether the sample tubes and collection tubes of the NAB Nanosep centrifugal devices contain detectable amounts of DNase or RNase.

8. mRNA Product Purification Process Strategies 2/15/2023

   Impurities from IVT can induce undesired immune responses and negatively impact translation efficiency. Explore the pros and cons of each option for mRNA purification.

9. Alternatives To CRISPR-Cas9: Nucleases For Next-Gen Therapy 10/28/2024

   Alternatives to CRISPR-Cas9 address limitations like delivery challenges and off-target effects. Emerging nucleases offer improved specificity, smaller sizes, and therapeutic applications.

10. Study Viral Infection In Resting Human CD4+ T Cells 11/28/2023

    Explore a study proving how synthetic single guide RNAs were used to optimize the editing conditions for resting human CD4+ T cells and maintain high cell viability for several weeks post Nucleofection.