RNA Analytical Quality/Resources

1. Top 8 Benefits Of Mass Spectrometry Imaging Early In Drug Development 9/1/2024

   Here we explore the top 8 benefits of using mass spectrometry imaging in the oncology drug discovery and early development stages.

2. mRNA Product Purification Process Strategies 2/15/2023

   Impurities from IVT can induce undesired immune responses and negatively impact translation efficiency. Explore the pros and cons of each option for mRNA purification.

3. Future-Proofing mRNA Drug Manufacturing: The Value of Continuous Improvement 4/30/2024

   With so many uncertainties permeating the mRNA market, this largely preclinical industry is still seeking answers on how to reach successful therapeutic development. Identifying optimizations, both sequence-dependent and otherwise, to enhance the manufacturing process is crucial for advancing mRNA product development, which holds vast potential to address a wide range of indications.

4. Ultra-Sensitive Assay For Anti-Sense Oligonucleotide Quantification 3/1/2022

   Learn about a new level in sensitivity for challenging analytes in matrix that opens doors for accurate bioanalysis and metabolism studies with specificity not achievable with orthogonal methods.

5. Methods for mRNA Poly(A) Sizing 4/26/2024

   This study used Oxford Nanopore Technologies' Direct RNA Sequencing Kit and obtained successful sizing of poly(A) tail regions. The results are presented in a histogram and table format.

6. Lipid Nanoparticle Compositional Analysis By UHPLC-CAD 6/30/2023

   Explore results generated from an internal study using a proprietary mRNA-LNP formulation and UHPLC-CAD, a powerful technique for the analysis of compounds that do not contain chromophores.

7. Top 5 Approaches To The Bioanalysis Of Oligonucleotides 9/1/2024

   Evaluate the strengths and limitations of each bioanalysis method carefully to choose the most effective strategy for your clinical study.

8. Establishing Analytical Methods For mRNA-Based Therapies 6/13/2023

   Here, we provide a detailed description of assays for sequence identification and LNP composition in mRNA-LNP products that support the development of safe and effective mRNA therapies.

9. Limiting Off-Target Effects Of CRISPR-Based Products 2/11/2025

   Find out how to enhance CRISPR gene editing specificity by using Next Generation Sequencing to improve sgRNA quality control, addressing off-target effects and ensuring higher sequence fidelity.

10. Probing RNA Base Pairing And Ligand Interactions In Solution With Infrared-Based MMS 2/21/2025

    Discover why Microfluidic Modulation Spectroscopy (MMS) is a novel, label-free, solution-based infrared technique for probing RNA base pairing and ligand interactions.