RNA Analytical Quality/Resources

1. Pre-Banking And Avoiding Manufacturing Challenges For GMP Plasmids Containing Unstable Sequence Regions 4/21/2021

   Ensuring consistent replication and proper retention of plasmid DNA sequence is vital to the economics and efficiency in generating starting materials used for production of AAV delivered gene therapy and mRNA vaccines and therapeutics.

2. Precision In Nanoparticle Processing And Monodispersed Lipid Nanoparticles For Advanced Therapeutics 11/17/2025

   Precision in nanoparticle processing is key for drug delivery and vaccines. Learn how monodispersed formulations enhance reproducibility and stability for next-generation therapeutics, like RNA-LNPs.

3. From Data To Decisions: Accelerating Your mRNA Drug Development With Analytics 11/20/2024

   To stay ahead in the competitive landscape of mRNA development, adopt a comprehensive QC strategy today and begin conducting meaningful tests to ensure the quality of your test articles.

4. Comprehensive Characterization Of Oligonucleotides And Related Impurities 7/29/2026

   A two-dimensional LC/MS strategy improves the separation of coeluting oligonucleotide impurities. High-resolution sampling and automation enable deeper characterization of low-level variants.

5. Metabolite ID And Relative Quantification Of Oligonucleotides In Plasma 3/4/2022

   This technical note describes the identification, relative quantification, and structural confirmation of the chain-shortened metabolites of a phosphorothioated oligonucleotide.

6. CRISPR sgRNA For Successful Gene Editing: Discovery To Clinic 9/25/2023

   The single guide RNA (sgRNA) is one of the key components of successful CRISPR gene editing. Here we cover all the important aspects of sgRNA and Synthego’s sgRNA products.

7. Replicate Bioscience And Cytiva Collaborate To Deliver srRNA-LNP Vaccines 3/24/2025

   Discover how self-replicating RNA (srRNA) can revolutionize vaccine development with sustained protein expression, lower doses, and fewer side effects to advance next-gen RNA therapeutics.

8. Best Practices For Analysis Of In Vitro Transcribed (IVT) mRNA 11/20/2025

   Learn best practices for high-resolution analysis of IVT RNA using automated capillary electrophoresis. Improve accuracy and precision in quantifying critical quality attributes.

9. Structural Characterization Of RNA And Detection Of RNA-Ligand Binding 1/13/2025

   Delve into the intricacies of riboswitch behavior and ligand interactions and gain valuable insights into gene regulation and potential therapeutic targets.

10. Detection Of Adapter Dimers In NGS Libraries 3/4/2026

    Accurately identifying low‑level adapter dimers is key. Compare electrophoresis methods to show how different kits detect and resolve small fragments, helping researchers choose the best QC approach.