RNA Manufacturing Resources

31. Exosome Isolation By TFF And Size Exclusion Chromatography 3/6/2024

    Here, we demonstrate a scalable workflow for the isolation of exosomes that combines tangential flow filtration for the concentration of exosomes followed by gentle size exclusion chromatography.

32. Aseptic Process Sampling Risk Mitigation – A Regulatory Perspective 6/22/2020

    This overview outlines regulatory guidelines for sampling, examines the limitations of conventional methods, and emphasizes the advantages of aseptic, single-use approaches in achieving compliance.

33. Digital Solutions Advance Your mRNA Manufacturing Workflow 6/17/2024

    Explore the advantages of paperless manufacturing, the importance of incorporating a digital strategy early in the process, and how digital solutions for mRNA manufacturing can help enhance production.

34. 5 IVT Design Considerations Before Scale-Up 7/29/2026

    As RNA programs advance toward clinical manufacturing, five IVT design questions can help teams identify hidden process risks before scale-up exposes them.

35. Rapid Separation Of Circular RNA Using An mRNA Analysis Kit 8/11/2023

    Achieve high-resolution separation of circular RNA (circRNA) species from linear RNA products, and detect impurities present at 0.1% of that main product, using an mRNA analysis kit.

36. Bio4C ProcessPad™ 21 CFR Part 11 Compliance 1/12/2021

    Learn how Bio4C ProcessPad™ meets 21 CFR Part 11 requirements including unique usernames and passwords, timestamped audit trails, and secure storage of all records.

37. A Proven Platform For Solid-Phase Oligonucleotide Synthesis 5/25/2022

    Facilitating oligonucleotide synthesis with state-of-the-art equipment and process support is critical to maximizing oligo production and achieving consistency at scale.

38. Accelerate GMP Certification With Annex 1-Compliant Aseptic Automation 1/9/2026

    Rapid GMP certification is possible with Annex 1-aligned aseptic workflows that reduce contamination risks. Learn how advanced automation and isolator technologies help CDMOs meet regulatory demands.

39. LNP Formulation For mRNA Delivery 2/15/2023

    Microfluidic mixing is one of the most effective means to formulate LNPs for its scalability and reproducibility. Explore LNP formulation, polishing, sterile filtration of mRNA-LNPs, and more.

40. Review Of mRNA Vaccines & Therapeutics Manufacturing Challenges 10/11/2022

    Learn more about the challenges that arise during the synthesis, purification, and encapsulation of mRNA.