RNA Manufacturing Resources

  1. Exosome Isolation By TFF And Size Exclusion Chromatography 3/6/2024

    Here, we demonstrate a scalable workflow for the isolation of exosomes that combines tangential flow filtration for the concentration of exosomes followed by gentle size exclusion chromatography.

  2. Establishing Analytical Methods For mRNA-Based Therapies 6/13/2023

    Here, we provide a detailed description of assays for sequence identification and LNP composition in mRNA-LNP products that support the development of safe and effective mRNA therapies.

  3. Oligonucleotide Development And Manufacturing Workflow 3/28/2022

    Learn more about oligo workflows and solutions for oligonucleotide process development, from scalable oligo synthesis to cleavage and deprotection, purification, and buffer exchange.

  4. The Crucial Role Of Downstream Processing In Optimizing RNA-LNP Drug Development 8/28/2024

    Explore the key aspects of lipid nanoparticle (LNP) development, including the essential downstream processes of Tangential Flow Filtration (TFF) and normal flow filtration.

  5. Size Matters: Mastering Size Exclusion For Oligos 12/15/2025

    Learn how to separate molecules strictly by size, effectively remove salts, and select the correct pore specifications for a gentle, non-destructive purification workflow.

  6. Best Practices For Analysis Of In Vitro Transcribed (IVT) mRNA 11/20/2025

    Learn best practices for high-resolution analysis of IVT RNA using automated capillary electrophoresis. Improve accuracy and precision in quantifying critical quality attributes.

  7. How mRNA Technology Is Shaping The Future Of Medicine 1/4/2022

    Discover how mRNA technologies open the doors to a whole range of new gene therapies and the role of lipid nanoparticles (LNPs) in current and future developments.

  8. Next-Gen Bioprocess Monitoring: Smart Data Management And Analysis 10/14/2020

    A new platform that includes digital technologies/data management, process analytical technologies and intensified processing will drive next generation bioprocessing.

  9. How Data Analytics Accelerates Transition To Bioprocessing 4.0 4/7/2023

    Following successful Industry 4.0 implementation in the automotive, communications, aerospace, and other industries, the biopharma industry is now joining the digital revolution.

  10. The Power Couple: CRISPR And Oligonucleotides 3/4/2024

    Drug design using CRISPR depends on long guide RNA (gRNA) sequences. Find out how this match between long oligos and CRISPR works.