RNA Manufacturing Resources

  1. Workflow For Primary Human NK Cell Isolation, Xeno-Free Expansion, Harvest, And Cryopreservation 8/30/2018

    Obtaining primary human NK cells at clinically relevant scale is challenging. Find out how you can generate 109 cells using a xeno‑free NK cell expansion and several automated and functionally closed unit operations, suitable for cGMP environments.

  2. Screening T7 Polymerases To Optimize xRNA Yield And Quality 10/31/2025

    Discover how the evolution of T7 polymerase is optimizing in vitro transcription for RNA therapeutics. Learn to balance performance, cost, and supply to make smart choices for your xRNA manufacturing.

  3. A New Specialist For Oligonucleotides With Advantages 12/16/2025

    Discover how hybrid silica technologies ensure stability and high resolution in IP-RP chromatography applications while protecting instrumentation from excessive wear and tear.

  4. In-Process Control Of pDNA Production On CIMac™ pDNA Analytical Column 6/10/2021

    As the demand for plasmid DNA (pDNA) based gene therapy and vaccines increases, large-scale, cost-effective, and reproducible pDNA production is required. The key to success is a real-time in-process control method that ensures a high percentage of supercoiled pDNA in the final product. Read how the CIMac™ pDNA Analytical Column allows the monitoring of degradation products (open circular and linear pDNA), the removal of impurities (RNA), and ensures that each production step yields the amount of supercoiled pDNA anticipated.

  5. Effectively Scaling Up The Oligonucleotide Manufacturing Process 5/25/2022

    Learn how purpose-driven decisions backed by a thorough process that reaps you the largest profit potential over time can result in successful scale up.

  6. Production And Clarification Of Lentiviral Vectors 10/30/2024

    Explore scalable processes for lentiviral vector production and clarification at the 50 L scale, utilizing the CTS LV-MAX system and single-use bioreactors for robust gene therapy manufacturing.

  7. Insights Into GMP Manufacturing Of RNA-LNP Drug Products 2/29/2024

    Explore key considerations for manufacturing RNA-LNP drug products surrounding process and analytical development, automation, environmental monitoring, and strategic collaborations.

  8. Freezing mRNA: Best Practice 7/14/2023

    By following some of the best practices in freezing mRNA, you can effectively balance product quality, cost-effectiveness, process safety, and efficiency.

  9. Strategies To Overcome Delays In The Development Of Genomic Medicines 10/13/2022

    Learn how optimizing LNPs can help overcome drug-delivery challenges, unlocking potential new genomic medicines in a shorter time.

  10. Scalable Purification Of In Vitro Transcribed mRNA 7/18/2023

    Learn about the isolation and purification benefits of a resin that is particularly useful in the manufacturing in vitro transcribed mRNA.