RNA Analytical Quality/Resources

  1. Top 8 Benefits Of Mass Spectrometry Imaging Early In Drug Development 9/1/2024

    Here we explore the top 8 benefits of using mass spectrometry imaging in the oncology drug discovery and early development stages.

  2. Best Practices For Analysis Of IVT mRNA 11/20/2025

    Discover how an automated capillary electrophoresis system provides robust and precise integrity, concentration, and size analysis for IVT mRNA.

  3. Sequencing Of Synthetic Oligonucleotides And Their Impurities 9/20/2022

    We demonstrate an automated, compliance-ready liquid chromatography-mass spectrometry (LC-MS) workflow for sequence confirmation of oligonucleotides and their impurities.

  4. Lessons From Benchmarking Of dsRNA Across Polymerase Systems 5/1/2026

    Not all low-dsRNA claims hold up under direct comparison. A 15-enzyme IVT study identifies the few systems that actually deliver across yield, integrity, and dsRNA simultaneously.

  5. Five Essentials For Accurate Oligonucleotide Chemistry 3/4/2024

    Explore five key areas in oligonucleotide chemistry where improvements will have a huge influence on your synthesis quality.

  6. Preventive Control Of Sequencing Through The Insert 3/4/2026

    Understanding library size distributions helps prevent sequencing through the insert, reducing adapter read‑through. Explore how smear analysis guides optimal read‑length selection to avoid noise.

  7. Establishing Analytical Methods For mRNA-Based Therapies 6/13/2023

    Here, we provide a detailed description of assays for sequence identification and LNP composition in mRNA-LNP products that support the development of safe and effective mRNA therapies.

  8. Assessing Doggybone DNA For In Vitro Transcription 4/26/2024

    In this study, we evaluated the performance of two dbDNA IVT templates, each encoding the same mRNA (firefly luciferase or Fluc), by looking at the mRNA purity and in vivo potency of the mRNA IVT’d from each template.

  9. Optimizing mRNA For Success: A Guide To Enhanced Stability, Delivery, And Efficacy 6/11/2024

    RNA offers exciting potential for vaccines, gene therapies, and personalized medicine, but challenges related to stability, delivery, and manufacturing persist.

  10. The Absolute Essentials Of Manufacturability 11/12/2025

    Learn why integrating Quality by Design (QbD) and Process Analytical Technology (PAT) early on is essential for developing a robust, controlled, and financially viable process.