RNA Analytical Quality/Resources

  1. Analyzing Poly(A) Tails Of In Vitro Transcribed RNA 11/20/2025

    Find out how to achieve reliable IVT mRNA quality. Learn the best practices for precise analysis, including proper sample prep and system optimization for high-resolution results.

  2. Lentiviral Vector Characterization For Cell And Gene Therapy Manufacturing 6/20/2024

    This study focuses on characterizing recombinant LVVs used in gene-modified cell therapies, utilizing two real-time PCR assays adapted to the QuantStudio™ Absolute Q™ Digital PCR System.

  3. Metabolite ID And Relative Quantification Of Oligonucleotides In Plasma 3/4/2022

    This technical note describes the identification, relative quantification, and structural confirmation of the chain-shortened metabolites of a phosphorothioated oligonucleotide.

  4. Suitability Testing For IVT mRNA Analysis 11/20/2025

    Automated capillary electrophoresis provides robust, precise analysis of IVT mRNA integrity, concentration, and size, demonstrating excellent method precision.

  5. RNA Biotherapeutics — A New Approach To An Old Problem 2/22/2023

    Check out a brief history of RNA-based therapy and how Droplet Digital™ PCR supports this field of work.

  6. Development Of Alternative BCDP Reagents For The Synthesis Of 5' -Terminal Phosphate Oligonucleotides 11/25/2025

    New alternative phosphitylating reagents reduce the safety hazards associated with BCDP, enabling a safer and effective synthesis of key oligonucleotide sequences.

  7. Understanding RNA Higher-Order Structure Dynamics For CRISPR Applications 5/5/2025

    Scientists are gaining valuable knowledge about the structural dynamics of guide RNAs used in CRISPR-Cas9. This deeper understanding could pave the way for improved gene editing tools.

  8. Preventive Control Of Sequencing Through The Insert 3/4/2026

    Understanding library size distributions helps prevent sequencing through the insert, reducing adapter read‑through. Explore how smear analysis guides optimal read‑length selection to avoid noise.

  9. CRISPR Off-Target Editing: Prediction, Analysis, And More 2/28/2025

    A crucial consideration for researchers is off-target editing – unintended DNA modifications at sites other than the intended target. Explore the complexities and strategies to mitigate these effects.

  10. Alternatives To CRISPR-Cas9: Nucleases For Next-Gen Therapy 10/28/2024

    Alternatives to CRISPR-Cas9 address limitations like delivery challenges and off-target effects. Emerging nucleases offer improved specificity, smaller sizes, and therapeutic applications.