RNA Analytical/Quality Videos

1. Master Your mRNA Manufacturing 3/4/2025

   Join pDNA and mRNA specialists as they discuss innovative mRNA manufacturing solutions for your purification challenges, mRNA stability, and overall product quality.

2. The 20-Method Hurdle: Confronting the Operational Burden of mRNA Release 6/9/2026

   Though this Advancing RNA Live panel believes we’re still at too early a stage to begin reducing the number of methods we need for release, Sanofi’s Philippe Talaga, AbbVie’s Elaine Peters, and Tessera’s Ilya Shestopalov had a few ideas on what we can/should be doing today to set us up for more streamlined release panels in the future.  

3. Primates, Patents, And Progress: Advancements In Rational LNP Design 2/24/2026

   In this opening Advancing RNA Live clip, NanoVation Therapeutics’ Dominik Witzigmann and Stealth Co’s John Zuris share the scientific advancements they’ve been watching most keenly in the LNP space, as well as some of the evolutions they’re seeing in the overall quality of our RNA-LNP products.

4. Why Current dsRNA Analytics Don't Quite Cut It 10/15/2025

   In this Advancing RNA Live segment, several speakers raise concerns about the industry's ability to accurately measure impurities, particularly dsRNA, arguing that current analytics are insufficient, especially for high-dose therapeutics.

5. Is QbD Actually Possible In mRNA Development Today? 8/22/2024

   As the panelists of this Advancing RNA LIVE discussion argue, there are several big limitations we face in implementing QBD today for RNA development.

6. Regulatory And Biosafety Testing Expertise 3/31/2026

   Advancing biologics requires confidence in safety, quality, and compliance. Learn how integrated analytical and biosafety testing, backed by decades of expertise, helps reduce risk.

7. Development Of A Mitra Tip Extraction Assay Coupled With LC-MSMS 1/15/2025

   Watch this rundown of a novel method for quantifying L-Citrulline, L-Arginine, and L-Argininosuccinic acid using Mitra tip extraction coupled with LC-MS/MS for enhanced accuracy and reproducibility.

8. LBA Vs. LC-MS: Competing Technologies At A Development Crossroad 2/6/2025

   Watch as bioanalytical experts Shane Karnik, MS, and Matt Hartle, Ph.D., explore why many sponsors are reevaluating the use of LBA for large molecule protein analysis in favor of LC-MS.

9. Decoding Regulatory Expectations: The Art Of A Successful IND Submission 6/24/2025

   Companies often underestimate the information required for IND submissions, particularly in a sector that’s as diverse as the mRNA sector. Here, former FDA reviewer Tiffany Lucas shares some of the missteps companies can make when first approaching the FDA with their IND. CureVac’s Ulrike Jägle furthers the discussion, offering a critical best practice she and her colleagues rely upon as well to streamline their regulatory interactions.

10. The Biggest Challenges In Adopting Enzymatic Ligation of gRNA 4/29/2026

    In this Advancing RNA Live clip, panelists Venkat Krishnamurthy and April Sena home in on the economic, molecular, and biological challenges complicating the transition to enzymatic ligation today.