RNA Analytical/Quality Videos

1. Analyzing COVID-19 Vaccine Purity Using LC-MS Technologies 11/8/2022

   Explore why process-related impurities are a concern in vaccines and present results and learnings from LC-MS analyses of several mRNA- and protein-based vaccines for COVID-19.

2. Optimal Tech For Predicting Drug Responses At The Cellular Level 4/1/2025

   Explore how preserving spatial molecular information and leveraging AI-driven spatial-omics can transform treatment prediction, patient stratification, and personalized medicine.

3. Navigating the Continuum of LNP Analytical Knowledge 6/9/2026

   In this clip, Advancing RNA Live speakers Elaine Peters, Philippe Talaga, and Ilya Shestopalov advocate for an orthogonal approach as we strive to better understand our LNP QAs — with particular attention paid to particle size.   

4. How Can Sponsors & CDMOs Collaborate On RNA Analytical/Process Development? 8/22/2024

   Having worked on both the innovator and CDMO sides of the industry, Advancing RNA LIVE panelist Khaled Yamout outlines where he sees the greatest weaknesses in these critical sponsor-CDMO partnerships and offers guidance.

5. The Purification Dilemma: Balancing Upstream & Downstream Investment 10/15/2025

   This Advancing RNA Live clip dives into the biggest challenges in mRNA purification and the critical debate on where to focus investment. Here, our three mRNA PD experts argue for a holistic process development strategy, challenging the traditional wisdom of optimizing the upstream process at any cost.

6. Goldilocks & The Guidances: Finding "Just Right" For RNA Regulations 6/24/2025

   Do we need more specific regulatory guidance for every RNA modality and therapeutic approach? We asked and the Advancing RNA Live audience answered… Here, panelists Tiffany Lucas and Ulrike Jägle address the audience’s responses, as well as share their thoughts on just how prescriptive the future of regulatory guidance for RNA therapeutics approaches could/should be..

7. The Importance of Automation & Digital Innovations In mRNA Production 4/11/2025

   In this segment of an Advancing RNA Live panel discussion, experts from Life Edit Therapeutics, Tune Therapeutics, and University of Sheffield share their perspectives on the role automation and digital tools (i.e., soft sensors, digital twins can play in helping us better control our manufacturing processes.

8. Nanoassemblr Blaze mRNA Vaccine Demo 4/13/2022

   NxGen Technology delivers a scalable means to perform the critical particle formation step in a nanomedicine development process.

9. LC/MS/MS Analysis Of Coproporphyrin 1, Coproporphyrin 3 In Human Plasma 2/17/2025

   This innovative approach holds promise for reducing the need for extensive clinical drug-drug interaction studies, potentially streamlining the drug development process.

10. Determining Fragment Length for Enzymatic Ligation of gRNA 4/29/2026

    Advancing RNA Live panelists Max De Long, Venkat Krishnamurthy and April Sena address two audience questions about the number/length of fragments for enzymatic ligation of gRNA.