RNA Analytical/Quality Videos

1. The State Of CircRNA Analytical Development 8/22/2024

   Advancing RNA LIVE panelist Jim Nolan of Sail Biomedicines fills us in on the extent to which we can rely on the linear mRNA analytical foundations established today.

2. Quality Concepts In GMP IVT mRNA Development, Manufacturing, And Analytics 2/13/2025

   Stay ahead in mRNA therapeutic development by mastering the essential quality systems, process controls, and analytical methods required for robust GMP production and efficient manufacturing.

3. Must-Have CDMO Capabilities And MSA Make-Or-Breaks For mRNA-LNP Outsourcing 2/10/2025

   Three Advancing RNA Live panelists share their greatest needs in outsourcing partnerships for mRNA/RNA-LNP products and where sponsors should be the most prescriptive when drafting an MSA with an outsourcing partner.

4. What The EMA Guidance Means For mRNA: Progress, Limitations, And Future Directions 6/24/2025

   Advancing RNA panelists Tiffany Lucas and Ulrike Jägle home in on the EMA’s guidance for mRNA vaccine quality, sharing their initial thoughts on the guidance’s strengths, while also addressing its limitations for those of us who may be working with mRNA in a therapeutic context.

5. Real-Time Protein Titer Measurements: Simple, Automated, And Compact Solution 7/3/2025

   Accelerate your workflow with an automated IgG titer solution. Obtain precise results quickly, enhancing efficiency from process development to manufacturing.

6. Using ddPCR Technology To Characterize The Poly(A) Tail Content 7/27/2023

   When characterizing 3’ poly(A) tail length and integrity, Droplet Digital PCR technology demonstrates an orthogonal or alternative method to help ensure the quality and consistency of mRNA products.

7. The Latest And Greatest Technological Innovations In mRNA-LNP Production 2/10/2025

   In this segment, Replicate Biosciences’ Andy Geall, Qian Ruan, & Alex Aust identify the most promising technological and raw material innovations that are influencing the drug substance and drug product production processes at CDMOs.

8. The Importance of Automation & Digital Innovations In mRNA Production 4/11/2025

   In this segment of an Advancing RNA Live panel discussion, experts from Life Edit Therapeutics, Tune Therapeutics, and University of Sheffield share their perspectives on the role automation and digital tools (i.e., soft sensors, digital twins can play in helping us better control our manufacturing processes.

9. Bioinformatics In mRNA Development: Classification And Integration Conundrums 6/24/2025

   As both Advancing RNA Live speakers point out in this segment, the MHRA guidance focuses deeply on the critical role bioinformatics and AI/ML approaches will play in the development of personalized immunotherapies. Here, Eliquent Life Sciences’ Tiffany Lucas and CureVac’s Ulrike Jägle address the biggest challenges they anticipate companies will face in meeting the agencies’ recommendations.

10. How Can Sponsors & CDMOs Collaborate On RNA Analytical/Process Development? 8/22/2024

    Having worked on both the innovator and CDMO sides of the industry, Advancing RNA LIVE panelist Khaled Yamout outlines where he sees the greatest weaknesses in these critical sponsor-CDMO partnerships and offers guidance.