RNA Analytical/Quality Videos

1. Must-Have CDMO Capabilities And MSA Make-Or-Breaks For mRNA-LNP Outsourcing 2/10/2025

   Three Advancing RNA Live panelists share their greatest needs in outsourcing partnerships for mRNA/RNA-LNP products and where sponsors should be the most prescriptive when drafting an MSA with an outsourcing partner.

2. Breaking New Ground: MHRA Embraces A Future With Patient-Specific mRNA 6/24/2025

   In this Advancing RNA clip, panelists Ulrike Jägle and Tiffany Lucas unpack the benefits they see to the MHRA's new guidance on mRNA cancer immunotherapies, including the agency’s support for bioinformatics approaches and its burgeoning framework for developing and justifying a truly personalized medicine.

3. Assessing The Quality & Maturity Of The Next-Gen Oligo Supply Chain 12/3/2025

   As our molecules grow more complicated, so, too, does the supply chain. Here, Advancing RNA Live speakers Khaled Yamout & Camp4’s Satya Kuchimanchi talk through how this growth challenges our understanding of raw material quality and how sponsors can better assess their suppliers.

4. LBA Vs. LC-MS: Competing Technologies At A Development Crossroad 2/6/2025

   Watch as bioanalytical experts Shane Karnik, MS, and Matt Hartle, Ph.D., explore why many sponsors are reevaluating the use of LBA for large molecule protein analysis in favor of LC-MS.

5. The Latest And Greatest Technological Innovations In mRNA-LNP Production 2/10/2025

   In this segment, Replicate Biosciences’ Andy Geall, Qian Ruan, & Alex Aust identify the most promising technological and raw material innovations that are influencing the drug substance and drug product production processes at CDMOs.

6. What Does 2025 (And Beyond) Hold For The RNA-LNP Space? 12/4/2024

   Three LNP experts share their thoughts on the incremental advancements they’d like to see the RNA-LNP space make in the next few years.

7. Development Of A Mitra Tip Extraction Assay Coupled With LC-MSMS 1/15/2025

   Watch this rundown of a novel method for quantifying L-Citrulline, L-Arginine, and L-Argininosuccinic acid using Mitra tip extraction coupled with LC-MS/MS for enhanced accuracy and reproducibility.

8. Advancing Peptide Characterization Of Critical Quality Attributes With MMS 11/12/2025

   Axxium uncovered hidden peptide aggregation using MMS technology, revealing process-related potency issues missed by conventional methods. Learn how advanced structural analysis can strengthen quality control and biologics development.

9. Quality Concepts In GMP IVT mRNA Development, Manufacturing, And Analytics 2/13/2025

   Stay ahead in mRNA therapeutic development by mastering the essential quality systems, process controls, and analytical methods required for robust GMP production and efficient manufacturing.

10. Best Practices In Aseptic Sampling To Improve Quality In Bioprocessing 5/30/2024

    Learn about the key aspects of aseptic sampling, appropriate methods and circumstances to perform sampling, and the impact a platform and sample containers can have on assay results and process dynamics.