RNA Manufacturing Resources

1. Contrast In Oligonucleotides 3/13/2024

   Explore the differences between research-use-only oligonucleotides and those manufactured in compliance with GMP 21 CFR 820.

2. How Robotic Isolator Technology Aligns To Annex 1 Principles 4/28/2025

   Robotic gloveless isolators provide exceptional automation to eliminate human intervention and reduce contamination risk. Discover how they ensure compliance with the EU Annex 1 guideline to enhance sterility, precision, and monitoring.

3. In-Process Control Of pDNA Production On CIMac™ pDNA Analytical Column 6/10/2021

   As the demand for plasmid DNA (pDNA) based gene therapy and vaccines increases, large-scale, cost-effective, and reproducible pDNA production is required. The key to success is a real-time in-process control method that ensures a high percentage of supercoiled pDNA in the final product. Read how the CIMac™ pDNA Analytical Column allows the monitoring of degradation products (open circular and linear pDNA), the removal of impurities (RNA), and ensures that each production step yields the amount of supercoiled pDNA anticipated.

4. Meeting Regulatory Requirements With Confidence 6/7/2024

   An outbreak of mycoplasma can halt a biopharmaceutical facility's production for months. Explore the impact of mycoplasma contamination and the most accurate and sensitive way to detect it.

5. The Chilled Future Of mRNA Filling And Freezing 4/17/2023

   Manufacturers at biotech and biopharma companies need help keeping up with continuously advancing novel treatments. Technologies that provide control over the freeze-thaw process offer solutions.

6. mRNA-LNP Nucleic Acid Assessment From Distinct Formulations 9/8/2023

   Review a showcase of a high throughput robust analysis for nucleic acid integrity and size assessment of mRNA-LNP samples using a multi-capillary system and purity and integrity analysis kit.

7. Fast And Efficient Extraction Of mRNA From IVT Mixtures 6/7/2021

   Here, a fast and efficient way to purify polyadenylated mRNA using affinity chromatography on the CIMmultus® Oligo dT column is presented.

8. Large Scale Purification Of Oligonucleotides With IEX 12/6/2024

   As oligonucleotide-based drugs gain momentum in therapeutic development, refining their manufacturing processes through solutions like ion exchange chromatography (IEX) becomes crucial.

9. The Paradigm Shift: From Scale-Up To Scale-Out In Genetic Medicine 2/18/2025

   The shift from "scale-up" to "scale-out" in genetic medicine enhances production speed, revolutionizing pharmaceutical manufacturing and accelerating life-saving therapies for global patient populations.

10. Genomic Medicine Demands Manufacturing Innovation 5/28/2024

    The promise of novel therapeutic modalities can only be realized when effective science is paired with efficient manufacturing to provide cost-effective therapies to patients in need.