RNA Manufacturing Resources

1. Optimization And Scale-Up Of A Plasmid DNA Production Process 9/30/2025

   Optimizing pDNA production in E. coli requires strategic media selection and scale-up planning. Explore a study that identifies ideal conditions for high-yield manufacturing.

2. How Is Additive Manufacturing Delivering On Sustainability Goals? 10/22/2024

   One of the key concerns for many biopharmaceutical companies is minimizing environmental impact. Learn about additive manufacturing and the significant advantages it offers to biomanufacturers.

3. Cell Therapy Manufacturing: The Supply Chain Challenge 4/1/2019

   Overcoming the challenges of manufacturing and administering a complex product to any patient is critical for delivering cell therapies. Two industry experts detail strategies to meet supply chain challenges.

4. Getting Genomic Medicines Ready For Prime Time 2/5/2024

   Explore the benefits of building a manufacturing process early, how research into LNPs in nucleic acid therapeutics will contribute to the development of future drugs, and more.

5. Understanding CRISPR Clinical Trials: Your Questions Answered 3/15/2023

   CRISPR technology is revolutionizing cell and gene therapies, but how do CRISPR clinical trials work? Follow this explanation of CRISPR therapies from the discovery phase to FDA approval.

6. GMP-Source® And Phase-Appropriate Use For Early-Stage Clinical Trials 9/16/2021

   GMP-Source is a more robust, less rigid alternative to full cGMP production that mirrors nearly all of the oversight and quality standards of full cGMP production while relaxing certain commercial standards, helping companies overcome the hurdles that can stall early development.

7. Production And Clarification Of Lentiviral Vectors 10/30/2024

   Explore scalable processes for lentiviral vector production and clarification at the 50 L scale, utilizing the CTS LV-MAX system and single-use bioreactors for robust gene therapy manufacturing.

8. How Pattern Search Finds Anomaly Patterns In Historical Machine Data 10/21/2020

   Owing to the sheer volume of data streaming from sensor profiles, anomalies observed during process monitoring in historical data are extremely difficult to search due to a lack of time series search tools. 

9. Increasing Productivity Of pDNA DSP Using Sample Displacement Chromatography 8/27/2021

   Here, two distinct polishing processes using monoliths are compared: bind-elute (BE) and the more recently developed sample displacement purification (SDP).

10. Review Of mRNA Vaccines & Therapeutics Manufacturing Challenges: Plasmid DNA Manufacturing 6/7/2022

    This review suggests technical remedial options for the production of pDNA and focuses on mRNA synthesis, purification, and encapsulation.