RNA Manufacturing Resources

1. Addressing Challenges In mRNA Drug Development And Manufacturing

   mRNA-based drug products serve as an ideal platform for use in infectious disease, protein replacement, and immuno-oncology applications due to the simplicity of manufacturing and robust immune response.

2. Amgen's Digital Transformation: Link Suppliers' Raw Material Data To Patients 10/19/2018

   Using its Supplier Relationship Excellence program, Amgen opened the lines of communication with suppliers and created a feedback loop where data can be shared to optimize operational performance. 

3. mRNA/saRNA Manufacturing - RNA Therapeutic Delivery And Applications 7/11/2023

   Venkata Indurthi, Ph.D., shares his knowledge and experience with manufacturing RNA, including insight into RNA delivery and the applications–present and future–that innovations in the field are enabling.

4. Future-Proofing mRNA Drug Manufacturing: The Value of Continuous Improvement 4/30/2024

   With so many uncertainties permeating the mRNA market, this largely preclinical industry is still seeking answers on how to reach successful therapeutic development. Identifying optimizations, both sequence-dependent and otherwise, to enhance the manufacturing process is crucial for advancing mRNA product development, which holds vast potential to address a wide range of indications.

5. Scaling Personalized Medicines For Flexible Aseptic Filling 2/14/2024

   Traditional aseptic filling solutions can introduce contamination and variability. Learn about Cytiva's commitment to finding innovative solutions and improving patient outcomes in the field of medicine.

6. Optimizing Lipid Formulations For Targeted RNA-LNP Applications 9/13/2022

   Learn about the considerations and challenges of using ionizable lipids, including the 5 types of lipids used for RNA delivery.

7. Effectively Scaling Up The Oligonucleotide Manufacturing Process 5/25/2022

   Learn how purpose-driven decisions backed by a thorough process that reaps you the largest profit potential over time can result in successful scale up.

8. Solvent-Free Purification Of D84-mer Oligonucleotide Using Capto™ PlasmidSelect Resin 1/13/2025

   Discover a solvent-free process using Capto PlasmidSelect and Capto Q ImpRes resins. They enable high-purity, scalable purification of long oligonucleotides, achieving more than 95% of full-length product purity.

9. GMP Manufacturing Facility For Viral Vector Production 3/27/2018

   A new GMP production facility for viral vectors from nonadherent cell cultures alleviates concerns that there will be a restriction of speed in getting viral vector products from the laboratory to the patient.

10. mRNA Manufacturing And Formulation 11/15/2022

    From fermentation to formulation, mRNA manufacturing requires a toolbox of technologies, services, and expertise. Explore our portfolio of solutions for making, purifying, and formulating mRNA.