RNA Formulation Resources

1. Transferring From Microfluidics To A Turbulent Mixer 4/18/2024

   What solutions did the client featured in this case study find when they sought help in transferring their formulation process to a turbulent Impinged Jet Mixing (IJM)?

2. How mRNA Technology Is Shaping The Future Of Medicine 1/4/2022

   Discover how mRNA technologies open the doors to a whole range of new gene therapies and the role of lipid nanoparticles (LNPs) in current and future developments.

3. Freezing mRNA: Best Practice 7/14/2023

   By following some of the best practices in freezing mRNA, you can effectively balance product quality, cost-effectiveness, process safety, and efficiency.

4. Exploring Osmolality As A CQA Within RNA Therapeutics 10/3/2023

   Discover how osmolality can be applied throughout the bioprocessing workflow for RNA, and recognize the importance of this sensitive measurement, from formulation optimization to cryopreservation techniques.

5. Potent Immune Response With Vernal's LNP-mRNAs 4/26/2024

   As mRNA medicine continues to evolve, understand how trusted manufacturing partners will continue to play a pivotal role in translating innovative concepts into clinical reality.

6. A Novel RNA Lipid Nanoparticle Platform: Gene-Edited CAR T Cells For Off-The-Shelf Cancer Therapy 4/14/2022

   We report on the use of a novel lipid nanoparticle (LNP) reagent in a validated protocol to achieve successful complex gene editing in primary T cells with high efficiency while maintaining high cell viability.

7. Formulation Process And Analytical Development Capabilities 3/25/2024

   Explore process and analytical development capabilities that can help you advance your formulation to GMP Manufacturing.

8. Understanding The Microfluidic Platforms For Scaling Nanoparticle Production 10/13/2022

   Learn about the benefits of microfluidics for nanoparticle production over traditional methods as well as scaling nanoparticle production for clinical or industrial use.

9. Optimizing Lipid Formulations For Targeted RNA-LNP Applications 9/13/2022

   Learn about the considerations and challenges of using ionizable lipids, including the 5 types of lipids used for RNA delivery.

10. Scale-Up And Manufacturing Of Self-Amplifying RNA-LNPs 4/18/2022

    This poster shows the work to scale up COVID-19 self-amplifying RNA-Lipid nanoparticle using PNI developed ionizable lipid and formulation from 0.2, to 50 mg scale using PNI’s Manufacturing Platform.