RNA Formulation Resources

1. Targeted LC-MS/MS Detection Of Lipid Impurities In Lipid Nanoparticles 12/9/2024

   Learn about an HPLC-MS/MS method for detecting lipid impurities in lipid nanoparticles (LNPs) and why it is critical for quality control of LNP-based drug delivery systems.

2. Regulatory Considerations For Excipients Used In Lipid Nanoparticles 8/15/2024

   Review the regulatory classification of LNPs, liposomes, and novel excipients as well as specific requirements outlined in regulatory guidance documents and strategies to navigate emerging challenges.

3. Advancing RNA-LNP Therapeutics As An Alternative To Viral Vectors 11/17/2025

   RNA-LNP therapeutics offer a flexible, transient alternative to traditional viral vectors for genetic medicine. Learn about the advantages of LNPs in safety, scalability, and payload versatility.

4. Novel Lipid Nanoparticle Delivery Reagent And Manufacturing Workflow 4/18/2022

   We aim to highlight that commercially available LNP reagent mix, GenVoy-ILM, is an accessible and easy-to-use LNP formulation that allows for rapid preclinical development of RNA vaccines.

5. Optimizing Lipid Formulations For Targeted RNA-LNP Applications 9/13/2022

   Learn about the considerations and challenges of using ionizable lipids, including the 5 types of lipids used for RNA delivery.

6. Translation Of RNA Medicines From Design To Clinic 3/2/2022

   Understand the advantages and challenges of lipid-based delivery systems for successful translation of RNA into clinical development.

7. Leveraging Single-Use Technology For mRNA-LNP Drug Manufacturing 6/12/2023

   Single-use technology is vital for ensuring the quality and expedited market entry of genomic medicines. Learn how LNP technology is paving the way for a new era of personalized, precise medicine.

8. Enabling Continuous Manufacturing For CAR-T And LNP-Based Therapies 6/27/2025

   Breakthrough therapies are challenged by complex, batch-based manufacturing. A novel, integrated system enables continuous processing, improving consistency and reducing manual handling for advanced modalities.

9. Levers To Optimize The IVT Reaction For Increased mRNA Yield 2/10/2026

   Mastering IVT yield requires balancing magnesium and nucleotide ratios. Learn how specific buffers and pyrophosphatase optimize mRNA synthesis for scalable, high-quality therapeutic production.

10. mRNA-Lipid Nanoparticles Circumvent Viral Vector Limitations 6/1/2022

    Both physical and chemical nonviral gene delivery systems for ex vivo genetic modification offer advantages over viral vectors, including smaller scale production and the low risk of immunogenicity.