RNA Analytical/Quality Videos

  1. Is the mRNA Industry Aligned Around LNP CQAs? 6/9/2026

    In this Advancing RNA Live clip, panelists Ilya Shestopalov, Philippe Talaga, and Elaine Peters share their perspectives on how aligned around our DP CQAs we are from a company and regulatory standpoint, and where specifically misalignments are revealing themselves today. 

  2. The Biggest Challenges Of Working With Ligase For siRNA Production 3/27/2026

    ALMAC expert Jill Caswell identifies the most overlooked challenges of working with ligase for the chemoenzymatic reaction, as well as the impact this is having today on enzyme engineering and purification. 

  3. mRNA/saRNA Manufacturing: Accelerate The Path To Clinic 3/22/2021

    Discover key upstream and downstream considerations for process development for RNA drug substance manufacturing and the parameters that need construct-specific optimization to increase yield and reduce impurities.

  4. Polymerase Selection And Its Impact On IVT Outcomes For Self-Amplifying RNA 6/10/2026

    Polymerase selection has measurable consequences for IVT outcomes in saRNA production, affecting dsRNA byproduct levels, capping efficiency, total yield, and transcript integrity across long templates.

  5. How Well Do We Know Our pDNA for mRNA Production? 10/29/2026

    How well do we really know our plasmid DNA quality for IVT? In this panel discussion, experts Philip Probert, Tyler Goodwin, Ben Clarke, and Nicolas Chaudet examine the ongoing challenges in determining pDNA CQAs and the analytical innovations required to reliably predict mRNA final product quality.

  6. How Analytical Development Is Informing mRNA Process Development Today 8/22/2024

    In this clip, Advancing RNA LIVE, panelists, share their perspectives on how advancements in RNA analytical development are complementing and informing process development efforts for linear mRNA.

  7. Navigating the Continuum of LNP Analytical Knowledge 6/9/2026

    In this clip, Advancing RNA Live speakers Elaine Peters, Philippe Talaga, and Ilya Shestopalov advocate for an orthogonal approach as we strive to better understand our LNP QAs — with particular attention paid to particle size.   

  8. Bioinformatics In mRNA Development: Classification And Integration Conundrums 6/24/2025

    As both Advancing RNA Live speakers point out in this segment, the MHRA guidance focuses deeply on the critical role bioinformatics and AI/ML approaches will play in the development of personalized immunotherapies. Here, Eliquent Life Sciences’ Tiffany Lucas and CureVac’s Ulrike Jägle address the biggest challenges they anticipate companies will face in meeting the agencies’ recommendations.

  9. A Double-Edged Sword? Defining "Efficiency" In mRNA Process Development 8/22/2024

    In this clip from a recent Advancing RNA LIVE event, panelists address a question about where the best opportunities exist upstream and/or downstream to increase mRNA manufacturing efficiencies.

  10. Real-Time Protein Titer Measurements: Simple, Automated, And Compact Solution 7/3/2025

    Accelerate your workflow with an automated IgG titer solution. Obtain precise results quickly, enhancing efficiency from process development to manufacturing.