RNA Analytical Quality/Resources

  1. Study Viral Infection In Resting Human CD4+ T Cells 11/28/2023

    Explore a study proving how synthetic single guide RNAs were used to optimize the editing conditions for resting human CD4+ T cells and maintain high cell viability for several weeks post Nucleofection.

  2. Large Scale Purification Of Oligonucleotides With IEX 12/6/2024

    As oligonucleotide-based drugs gain momentum in therapeutic development, refining their manufacturing processes through solutions like ion exchange chromatography (IEX) becomes crucial.

  3. High-Throughput Characterization Of RNA 5/9/2022

    How a multi-capillary electrophoresis (CE) system is used to efficiently separate a wide range of RNA-based molecules by size and demonstrates the multiplex capability for RNA characterization.

  4. Novel Plasmid DNA-Encoded Poly(A) Tails For mRNA Synthesis 4/26/2024

    Here, we evaluate the stability of these variant poly(A) regions and the biological activity of the mRNA containing the variant poly(A) tails made from these templates.

  5. Determining RNA Integrity And Purity By Capillary Gel Electrophoresis 6/30/2023

    To ensure mRNA product quality, it's important to confirm the integrity of the RNA. Examine the results of a study challenging the performance of the CGE method in assessing mRNA integrity and purity.

  6. Selection And Evaluation Of Hybridization Capture Probes For LC/MS Analysis Of Oligonucleotides 4/23/2025

    To overcome challenges in oligonucleotide LC/MS bioanalysis, consider optimizing probe design by evaluating alternative chemistries like PNA for improved recovery and chromatographic performance.

  7. The Value Of Peptones For Enhancing Biopharmaceutical Productivity 11/18/2024

    Peptones, versatile media additives derived from various sources, offer numerous benefits for biopharmaceutical production.

  8. Reduce Contamination Risks When Storing Synthetic DNA 10/30/2023

    An alternative to traditional polyethylene bags is offering cell and gene therapy manufacturers a solution to contamination concerns regarding DNA or RNA fragments.

  9. Probing RNA Base Pairing And Ligand Interactions In Solution With Infrared-Based MMS 2/21/2025

    Discover why Microfluidic Modulation Spectroscopy (MMS) is a novel, label-free, solution-based infrared technique for probing RNA base pairing and ligand interactions.

  10. Expression Analysis Of CTLA-4, PD-1, And PD-L1 4/23/2025

    Advance personalized immunotherapy in NSCLC by leveraging qPCR-based analysis of CTLA-4, PD-1, and PD-L1 expression to identify predictive biomarkers and guide more effective treatment strategies.