RNA Analytical Quality/Resources

  1. A New Era Of mRNA Potency And Safety 6/10/2026

    Selecting the right RNA polymerase and cap analog pairing significantly impacts mRNA yield, purity, and immunogenic safety, yet many production workflows still rely on a single industry-standard enzyme.

  2. Twist Of Two: 2D-LC For Oligos 12/16/2025

    Discover how coupling orthogonal mechanisms reveals hidden impurities and creates a more robust strategy for characterizing complex oligonucleotide samples.

  3. The Value Of Peptones For Enhancing Biopharmaceutical Productivity 11/18/2024

    Peptones, versatile media additives derived from various sources, offer numerous benefits for biopharmaceutical production.

  4. Demystifying CRISPR gRNA Chemical Modifications 10/28/2024

    Chemical modifications on CRISPR gRNAs enhance stability, editing efficiency, and reduce immune responses, enabling in vivo applications and clinical success.

  5. Best Practices For Analysis Of IVT mRNA 11/20/2025

    Discover how an automated capillary electrophoresis system provides robust and precise integrity, concentration, and size analysis for IVT mRNA.

  6. Lessons From Benchmarking Of dsRNA Across Polymerase Systems 5/1/2026

    Not all low-dsRNA claims hold up under direct comparison. A 15-enzyme IVT study identifies the few systems that actually deliver across yield, integrity, and dsRNA simultaneously.

  7. Mastering mRNA Manufacturing: A Focus on Raw Materials & Supply Assurance 10/23/2024

    Rapid advancements in mRNA-based therapeutic development have underscored the role of raw material quality and supply chain management in ensuring their successful production.

  8. Pre-Banking And Avoiding Manufacturing Challenges For GMP Plasmids Containing Unstable Sequence Regions 4/21/2021

    Ensuring consistent replication and proper retention of plasmid DNA sequence is vital to the economics and efficiency in generating starting materials used for production of AAV delivered gene therapy and mRNA vaccines and therapeutics.

  9. Determining RNA Integrity And Purity By Capillary Gel Electrophoresis 6/30/2023

    To ensure mRNA product quality, it's important to confirm the integrity of the RNA. Examine the results of a study challenging the performance of the CGE method in assessing mRNA integrity and purity.

  10. How Automated NGS Solutions Advance Rare Disease Research 2/27/2026

    See how a unified NGS workflow is helping a major pediatric genetics lab boost efficiency, manage growing sample volumes, and accelerate insights into rare diseases through streamlined automation.