RNA Manufacturing Resources

  1. Accelerated Development: Gene Therapy Vs. Small Molecule 12/26/2023

    Combined with the inherent difficulty of the chemistry behind gene therapy development, its pace, structure, and funding dynamics are unique among treatment modalities.

  2. Use Of Filtration Plates For Purification Of DNAs For Sequencing Library Preparation 7/8/2022

    Discover how we examined a DNA sample purification method employing 96-well filter plates as an alternate to organic extraction.

  3. Considerations And Strategies For Oligonucleotide Manufacturing Scale-Up 8/2/2023

    To keep up with oligonucleotide demand, manufacturing needs to shift toward larger-scale processes, but this scale-up process brings challenges that must be addressed.

  4. Analytics And Bioassays Can Safely Fast-Track mRNA-LNP Drug Development 2/23/2023

    One main mRNA technology challenge is the formulation of delivery systems like lipid nanoparticles (LNPs). Learn about evading impurities in lipids, the future of mRNA-based genomic medicines, and more.

  5. Enhanced mAb Production With High-Intensity Perfusion CHO Medium 11/27/2024

    Reach new heights in mAb production with a high-intensity perfusion CHO medium designed to support consistently high product yield and quality in continuous perfusion cultures using CHO-K1 cells.

  6. A Novel RNA Lipid Nanoparticle Platform: Gene-Edited CAR T Cells For Off-The-Shelf Cancer Therapy 4/14/2022

    We report on the use of a novel lipid nanoparticle (LNP) reagent in a validated protocol to achieve successful complex gene editing in primary T cells with high efficiency while maintaining high cell viability.

  7. Automation And Digital Solutions Can Help You Reach Your mRNA Manufacturing And Sustainability Goals 1/14/2025

    Explore how digital solutions help streamline mRNA manufacturing by reducing costs, improving efficiency, and supporting sustainability by creating paperless processes for emerging therapeutics.

  8. The Chilled Future Of mRNA Filling And Freezing 4/17/2023

    Manufacturers at biotech and biopharma companies need help keeping up with continuously advancing novel treatments. Technologies that provide control over the freeze-thaw process offer solutions.

  9. Optimizing siRNA Therapeutics: Addressing Manufacturing Complexities 3/21/2025

    Discover key strategies to optimize siRNA therapeutics by addressing critical nonclinical and manufacturing challenges for a smoother path to commercialization.

  10. Fast Track RNA-LNP Drug Development By Lowering The Lipid Barrier 8/21/2023

    Fast-track RNA-LNP development, streamline screening with off-the-shelf ionizable lipid mixes, and utilize validation strategies to generate reproducible and scalable LNPs for lead candidates.