RNA Manufacturing Resources

  1. Purification And QC Of An RNA 21‑Mer Oligonucleotide Via LC‑MS 1/27/2026

    Learn how buffer choice, gradient strategy, and pretreatment steps influence recovery, purity, and resolution when purifying a native RNA oligo, with analytical confirmation and practical guidance.

  2. Multivariate Inter-Stage Batch Profile Monitoring And Future State Estimation 2/3/2022

    How much quicker and easier would it be if we could know the process’s health by looking at a single metric rather than checking hundreds of parameters?

  3. How Robotic Isolator Technology Aligns To Annex 1 Principles 4/28/2025

    Robotic gloveless isolators provide exceptional automation to eliminate human intervention and reduce contamination risk. Discover how they ensure compliance with the EU Annex 1 guideline to enhance sterility, precision, and monitoring.

  4. Aseptic Process Design And Simulation Under Annex 1 Guidelines 1/9/2026

    Gain insight into how Annex 1 reshapes aseptic process validation, as well as into risk reduction by design and why isolators are redefining modern sterile manufacturing standards.

  5. Metabolite ID And Relative Quantification Of Oligonucleotides In Plasma 3/4/2022

    This technical note describes the identification, relative quantification, and structural confirmation of the chain-shortened metabolites of a phosphorothioated oligonucleotide.

  6. Aseptic Process Sampling Risk Mitigation – A Regulatory Perspective 6/22/2020

    This overview outlines regulatory guidelines for sampling, examines the limitations of conventional methods, and emphasizes the advantages of aseptic, single-use approaches in achieving compliance.

  7. Comprehensive Characterization Of Oligonucleotides And Related Impurities 7/29/2026

    A two-dimensional LC/MS strategy improves the separation of coeluting oligonucleotide impurities. High-resolution sampling and automation enable deeper characterization of low-level variants.

  8. Optimizing siRNA Therapeutics: Addressing Manufacturing Complexities 3/21/2025

    Discover key strategies to optimize siRNA therapeutics by addressing critical nonclinical and manufacturing challenges for a smoother path to commercialization.

  9. Aseptic Filling By Design: Shaping The Future Of Drug Manufacturing 3/20/2026

    Modern therapies demand higher sterility assurance and flexible operations. Discover how advanced contamination control, barrier systems, and automation strengthen quality and support faster delivery.

  10. New To mRNA Manufacturing? Considerations For Starting 6/15/2022

    Explore considerations for starting mRNA manufacturing related to the following topics: DNA template, mRNA product - IVT, mRNA product - purification, LNP encapsulation, and fill-finish.