RNA Formulation Resources

1. Translation Of RNA Medicines From Design To Clinic 3/2/2022

   Understand the advantages and challenges of lipid-based delivery systems for successful translation of RNA into clinical development.

2. Developing An mRNA-Encoded Antibody Platform To Accelerate Therapies To Clinic 11/20/2024

   In this paper, we present the foundation of an mRNA-LNP platform for encoding and expressing therapeutic antibodies in vivo, eliminating the need for costly and time-consuming manufacturing.

3. Transferring From Microfluidics To A Turbulent Mixer 4/18/2024

   What solutions did the client featured in this case study find when they sought help in transferring their formulation process to a turbulent Impinged Jet Mixing (IJM)?

4. Process Development Considerations For RNA-LNP Therapeutics 9/13/2022

   Here, we highlight three important process considerations across the RNA-LNP manufacturing workflow which includes limit size behavior, in-line dilution and downstream tangential flow filtration (TFF).

5. Developing A Scalable RNA-LNP Drug Product For Clinical Translation 9/22/2022

   Accelerate essential process development activities with instrumentation solution allowing for highly reproducible and scalable production of RNA-LNPs.

6. Ophthalmic Drug Delivery 4/11/2024

   Explore the challenges to effective delivery of drugs to the eye, intricacies of ophthalmic drug delivery, and advantages of nanoparticles as an enabling technology for ocular drug-delivery systems.

7. Nanoparticle Engineering Addresses The Challenge Of Poor Aqueous Solubility 3/24/2023

   As pharma companies aim to overcome development obstacles, it is important to incorporate GMP expertise alongside novel technologies that can enhance the properties of APIs and dosage forms.

8. Versatile Lipid Nanoparticle Platform For Efficient Gene Editing 6/3/2025

   Lipid nanoparticles enable efficient gene editing in hard-to-transfect cells like T-cells and blood stem cells, which offers scalable, clinically relevant methods for developing advanced therapies for cancer and rare diseases.

9. Lipid Nanoparticle Library For Non-Viral Delivery Of mRNA And saRNA Towards Vaccine And Cell & Gene Therapy Applications 4/18/2022

   Explore this proprietary ionizable lipid library which has shown promising potency towards various applications involving cell therapy, protein replacement therapy and RNA-based Vaccines.

10. Fit-For-Purpose Lipids Can Accelerate, Scale, And Improve RNA-LNP Drugs 6/22/2023

    Emerging biotech companies are investing in novel delivery capabilities to address different modalities' needs and extra-hepatic delivery. Explore steps to accelerate commercial nanomedicine delivery.