RNA Formulation Resources

1. Leveraging Single-Use Technology For mRNA-LNP Drug Manufacturing 6/12/2023

   Single-use technology is vital for ensuring the quality and expedited market entry of genomic medicines. Learn how LNP technology is paving the way for a new era of personalized, precise medicine.

2. Insights Into GMP Manufacturing Of RNA-LNP Drug Products 2/29/2024

   Explore key considerations for manufacturing RNA-LNP drug products surrounding process and analytical development, automation, environmental monitoring, facility design, and strategic collaborations.

3. Genome Editing Using mRNA-Lipid Nanoparticles For CAR T Cell Therapy 11/22/2023

   Gene delivery platforms must support a diversity of genetic engineering strategies for genomic medicine development. Learn how lipid nanoparticles can accelerate development from discovery to scale-up.

4. PEG In LNP Formulations: Addressing Challenges And Seeking Solutions 2/8/2024

   Polyethylene glycol and similar variants have driven innovative research for therapies. However, the continued use of PEG poses significant drawbacks. Explore those concerns, here.

5. Trends In Next-Generation Delivery Technologies 11/22/2023

   Learn how lipid nanoparticles are enabling a new generation of engineered cell therapies with a push toward more complex cell engineering and gene editing for allogeneic therapies.

6. An Introduction And Brief History Of mRNA-LNPs 12/14/2023

   With adjustable components and increased stability during bloodstream circulation, LNPs are significantly advancing drug development and delivery, particularly for mRNA vaccines.

7. How mRNA Technology Engineers Next-Generation Antibodies 4/26/2024

   Monoclonal antibodies (mAbs) stand as pivotal drug products and biochemical reagents in the 21st century. Explore how mRNA-encoded antigens could revolutionize antibody discovery.

8. Getting Genomic Medicines Ready For Prime Time 2/5/2024

   Explore the benefits of building a manufacturing process early, how research into LNPs in nucleic acid therapeutics will contribute to the development of future drugs, and more.

9. Understanding The Microfluidic Platforms For Scaling Nanoparticle Production 10/13/2022

   Learn about the benefits of microfluidics for nanoparticle production over traditional methods as well as scaling nanoparticle production for clinical or industrial use.

10. Low-Volume Production For Screening High-Value Nanoparticle Materials 4/18/2022

    A platform which harnesses microfluidic mixing has been demonstrated as a simple, robust and scalable production method for LNPs encapsulating various types of nucleic acids.