RNA Formulation Resources

1. The Hitchhiker´s Guide To Creating Oligonucleotides From Start To Finish 12/15/2025

   Producing high-quality oligonucleotides demands precise execution across multiple stages. Gain a clearer understanding of the complete mid-scale production workflow and necessary quality control measures.

2. Exploring Osmolality As A CQA Within RNA Therapeutics 10/3/2023

   Discover how osmolality can be applied throughout the bioprocessing workflow for RNA, and recognize the importance of this sensitive measurement, from formulation optimization to cryopreservation techniques.

3. CQA Assessment Of LNP-Encapsulated IVT mRNA 4/21/2025

   Learn more about issued guidelines on Critical Quality Attributes for IVT mRNA vaccines and biotherapeutics to focus on drug substance and LNP-encapsulated drug product assessment using an analyzer system.

4. Versatile Lipid Nanoparticle Platform For Efficient Gene Editing 6/3/2025

   Lipid nanoparticles enable efficient gene editing in hard-to-transfect cells like T-cells and blood stem cells, which offers scalable, clinically relevant methods for developing advanced therapies for cancer and rare diseases.

5. Process Development Considerations For RNA-LNP Therapeutics 9/13/2022

   Here, we highlight three important process considerations across the RNA-LNP manufacturing workflow which includes limit size behavior, in-line dilution and downstream tangential flow filtration (TFF).

6. Standardize Scale-Up And Reduce Time To Market With Mixing Cartridges 7/21/2023

   Despite the momentum of the RNA-LNP therapeutic market, significant manufacturing challenges remain. However, the right mixing could solve three of these key challenges regarding instrumentation.

7. The Key To Accelerating RNA-LNP Drug Development 12/27/2023

   Learn about the drug development hurdles that must be overcome to deliver on the promise of mRNA.

8. CRISPR 101 - Your Guide To Understanding CRISPR 11/28/2023

   Review the fundamentals of CRISPR technology, development, and its use to manipulate genes in different ways, such as altering their nucleotide sequences or changing their expression.

9. The Value Of Premium Gibco Peptones 5/10/2024

   Achieve the optimal nutritional balance with diverse supplements tailored for your specific bioprocess that can be added to maintain a nutritionally balanced medium.

10. Levers To Optimize The IVT Reaction For Increased mRNA Yield 2/10/2026

    Mastering IVT yield requires balancing magnesium and nucleotide ratios. Learn how specific buffers and pyrophosphatase optimize mRNA synthesis for scalable, high-quality therapeutic production.