RNA Analytical/Quality Videos

1. The Latest And Greatest Technological Innovations In mRNA-LNP Production 2/10/2025

   In this segment, Replicate Biosciences’ Andy Geall, Qian Ruan, & Alex Aust identify the most promising technological and raw material innovations that are influencing the drug substance and drug product production processes at CDMOs.

2. CMC Innovations Worth Watching In The RNA-LNP Space 12/4/2024

   Sanofi’s Sumit Luthra shares several of the analytical and manufacturing innovations/improvements he’s watching and waiting for that will improve our knowledge of LNP composition, structure, function, and quality.

3. Optimal Tech For Predicting Drug Responses At The Cellular Level 4/1/2025

   Explore how preserving spatial molecular information and leveraging AI-driven spatial-omics can transform treatment prediction, patient stratification, and personalized medicine.

4. Webinar Teaser: LBA Vs. LC-MS 2/6/2025

   Why are so many sponsors shifting from Ligand-Binding Assays (LBA) to Liquid Chromatography-Mass Spectrometry (LC-MS) for large molecule protein analysis?

5. The Pre-IND "Diaries": What Can mRNA Makers Expect From Early FDA Engagement? 5/10/2024

   Nutcracker Therapeutics’ Oreanna Thomas shares her takeaways from a pre-IND meeting for one of the company’s mRNA therapeutic candidates.

6. Advancements In LNP CMC: What Are The Current "Known Knowns"? 12/4/2024

   In this Advancing RNA Live clip, Sanofi’s Sumit Luthra highlights the learnings we’ve made to-date about how our processes — both in terms of unit operations and process conditions — inform our LNP composition/heterogeneity.

7. RNA Interference - From Single Gene Studies To Whole Genome Screens 11/7/2022

   Endoribonuclease-prepared siRNAs (esiRNAs) are able to overcome the limitations of RNAi. Learn about esiRNAs, their advantages over standard siRNAs, and ways this technology is utilized in different research fields.

8. Development Of COVID-19 Vaccine Production During A Pandemic 2/20/2025

   See how seamless teamwork and automated electrophoresis systems ensured rapid, reliable COVID-19 vaccine production support and how their collaboration made a difference.

9. Purification Of DNA Oligonucleotides Using AEX Chromatography Webcast 4/25/2023

   Explore impurities removed by strong anion exchange chromatography for the advancement of these molecules as therapeutics and a cost-effective, efficient, and scalable purification method.

10. Quality Concepts In GMP IVT mRNA Development, Manufacturing, And Analytics 2/13/2025

    Stay ahead in mRNA therapeutic development by mastering the essential quality systems, process controls, and analytical methods required for robust GMP production and efficient manufacturing.