Our Expert Network

1. Structure-Guided siRNA Design: How Chemistry, Context, And Constraint Are Shaping The Next Phase Of RNAi Therapeutics 6/8/2026

   As siRNA design matures, the next breakthroughs will depend on balancing chemical optimization, delivery challenges, and expanding beyond established design rules.

2. Scaling RNA Therapeutics: Purification, LNP Formulation, And GMP Manufacturing (Pt. 2) 6/4/2026

   Part 2 explores the downstream technologies that turn RNA into a therapeutic product, from impurity removal and LNP formulation to GMP infrastructure and scalable manufacturing.

3. From Exosomes To Nanodrugs: Advancing Therapeutic Delivery For CNS Repair 6/1/2026

   Exosomes are biological vesicles used for cellular communication that can overcome CNS barriers, delivering therapeutic cargo for CNS and optic nerve injuries.

4. Why RNAi-Based Oncology Must Move Beyond Single-Target Thinking 5/29/2026

   RNAi therapeutics may help oncology move beyond single-target drugs by disrupting adaptive tumor survival networks driving resistance in solid tumors.

5. What Makes An RNA Platform Investable? Lessons From The Last Wave Of Biotech Financing 5/28/2026

   RNA investing has shifted from hype to scalability, forcing companies to prove manufacturability, delivery strength, and platform-wide value.

6. RNA Manufacturing Foundations: From DNA Templates To In Vitro Transcription (Pt. 1) 5/27/2026

   Cell-free RNA production is reshaping biomanufacturing through modular IVT workflows, advanced capping strategies, and scalable DNA template design.

7. Beyond Hairpins: A New Translational Repression Assay Expands RNA-Binding Protein Research 5/26/2026

   Researchers expanded translational repression assays beyond RNA hairpins, enabling scalable study of linear RNA-protein interactions in living cells.

8. Engineering RNA Payload Distribution In LNPs To Unlock Higher In Vivo Gene Editing Efficiency 5/22/2026

   New research shows RNA payload distribution inside LNPs — not just encapsulation efficiency — may be key to unlocking stronger in vivo gene editing performance.

9. Beyond Guanidine: Scientists Discover A Mysterious Riboswitch Variant With A Different Biological Target 5/22/2026

   Scientists identified a mysterious riboswitch variant that resembles guanidine sensors but likely evolved to detect an entirely different metabolite.

10. RNA Modification-Mediated Translational Control In Immune Cells 5/20/2026

    Exploring how m6A RNA modifications control immune cell translation, influencing inflammation, tumor immunity, T cell activation, and future immunotherapies.