Listen & Watch

1. Achieving Next-Generation mRNA-LNP Therapeutics Delivery 11/6/2024

   It’s impossible to attend an event on the future of RNA therapeutics without hearing about the challenges we’re facing with targeted RNA-LNP delivery. In this final Advancing RNA Live discussion of 2024, we sat down with three LNP experts to parse out the current opportunities and unknowns facing the development of next-generation LNPs.

2. From Bottleneck To Breakthrough: Reimagining The mRNA Therapeutics Supply Chain 9/26/2024

   The supply chain for mRNA-based cell and gene therapies presents unique challenges due to the sensitive nature of these products. And, as mRNA technology continues to advance, robust processes and scalable solutions are necessary to meet increasing demand.

3. Can We Do Better? Current & Future Realities of mRNA Process Development 8/7/2024

   There’s been great progress in establishing processes and platforms for linear mRNA vaccines — but where does this current know-how fall short for those exploring linear and next-gen RNA constructs for therapeutic (non-vaccine) products?

4. Opening The "Black Box" Of The mRNA Regulatory Paradigm 5/2/2024

   This Advancing RNA panel discussion covers the broad learnings therapeutics developers can (or can’t) adapt from the previously approved mRNA vaccine products, and what an “ideal” RNA therapeutics regulatory paradigm could look like

5. Got Raw Materials? The State Of The mRNA Supply Chain 2/21/2024

   This discussion delves into how Advancing RNA can address concerns over the current “health” and availability of both small- and large-scale RNA therapeutics.

6. mRNA For Cancer Immunotherapy: 2024 Outlook 12/5/2023

   As additional mRNA-based cancer immunotherapies vaccines enter clinical development, operational and supply chain challenges must be addressed to reduce turnaround times and COGS.

7. mRNA Update: Beyond Prophylactic Vaccines 10/10/2023

   mRNA-based therapeutics are widely regarded as a “next big thing” in biopharma, but manufacturing them is fraught with complex challenges. Check out this digital event from Bioprocess Online Live featuring a discussion with mRNA process development experts on the front lines of the mRNA therapeutics revolution.

8. Risk Reduction In mRNA Therapeutic Development 9/13/2023

   mRNA is at an inflection point. To reach its therapeutic potential in chronic, and even rare, disease applications, some biopharmaceutical manufacturing fundamentals must be addressed.

9. Major Trends In Next-Gen RNA Engineering 6/13/2023

   From tissue specificity to potency and durability, major trends in RNA are developing as the space continues to evolve at record-breaking speed. In June 2023, Cell & Gene Live welcomed Nathaniel Wang, CEO and Co-Founder, Replicate Bioscience and Sam Deutch, EVP of Research and Early Development at Nutcracker Therapeutics for a deep dive into how RNA can accelerate drug development and how the evolution in the scale-up production of novel engineering technologies impacts near- and long-term deployment of new therapies.

10. Revolutionary Incrementalism: Future-Proofing mRNA Drug Manufacturing 3/28/2023

    Industry experts share go-to best practices, suggestions, and experiences for prioritizing and streamlining technical operations endeavors to prepare mRNA therapeutics companies for the clinic and, eventually, the commercial market.