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| It’s impossible to attend an event on the future of RNA therapeutics without hearing about the challenges we’re facing with targeted RNA-LNP delivery. In this final Advancing RNA Live discussion of 2024, we sit down with three LNP experts to parse out the current opportunities and unknowns facing the development of next-generation LNPs. Secure your spot today! Registration is free thanks to the support of Helix Biotech. |
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By AR Welch, Editorial & Community Director, Advancing RNA | Though mRNA may, in theory, be the “perfect technology” for scaling up/out and down, several industry experts from a panel during Cytiva’s recent RNA-LNP Summit explained that the successful transition from large to small-scale, high-quality mRNA production demands specific manufacturing capability improvements/advancements. |
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By A. Lamontagne, et. al., Dark Horse Consulting | These recommendations guide cell and gene therapy companies through the selection process for innovative tools, technology, and services with an eye to enable forward compatibility from early to later stages of development. |
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Having worked on both the innovator and CDMO sides of the industry, Advancing RNA LIVE panelist Khaled Yamout outlines where he sees the greatest weaknesses in these critical sponsor-CDMO partnerships and offers guidance on how both parties can improve their collaboration and communication. |
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| Scale-Up And Manufacturing Of Self-Amplifying RNA-LNPs | Poster | Precision NanoSystems | This poster shows the work to scale up COVID-19 self-amplifying RNA-Lipid nanoparticle using PNI developed ionizable lipid and formulation from 0.2, to 50 mg scale using PNI’s Manufacturing Platform. |
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| Novel Plasmid DNA-Encoded Poly(A) Tails For mRNA Synthesis | Poster | By L. Hinkel, N. Prugar, S. Chilton, O. McPhee, et al., Vernal Biosciences | Here, we evaluate the stability of these variant poly(A) regions and the biological activity of the mRNA containing the variant poly(A) tails made from these templates. |
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