RNA Supply Chain Videos

  1. Next-Generation RNA Modality Supply Considerations

    Together, Life Edit Therapeutics’ April Sena and Sanofi’s Troiano share their perspectives on raw material quality & IP-related considerations for managing the supply chain for next-generation RNA modalities.

  2. The State of the Linear mRNA Supply Chain—In Brief

    In this clip, Sanofi’s Greg Troiano kickstarts our discussion on some of the advances he’s seen in the supply chain for linear mRNA-LNP products, both in terms of supply availability and supplier capability.

  3. Taming dsRNA Via Innovation In The Supply Chain 10/15/2025

    Here, Ethris’ Christan Dohmen and Tune Therapeutics’ Stu Sundseth share their take on the most meaningful strategies for reducing dsRNA production. But this discussion also probes a deeper question: Is dsRNA still the most relevant impurity the industry should be chasing, or should focus shift to other contaminants? 

  4. Is The IVT Reaction A Coy Mistress? The Knowns & Unknowns 4/24/2023

    In this Bioprocess Online Live panel, we discuss two experts' perspectives on the current state of the mRNA supply chain for critical raw materials and manufacturing supplies and where pain points still exist.

  5. Enabling GMP Production Of sgRNA For CRISPR-Based Cell And Gene Therapies 10/28/2024

    Explore critical steps and key regulatory requirements for developing CRISPR therapeutics and gain practical advice on how to avoid common pitfalls.

  6. The Road To Metric-Ton siRNA Production: Is Enzymatic Ligation Ready For Commercial Volume? 3/27/2026

    Can we actually achieve metric-ton siRNA production using enzymatic ligation? While the ligation step is highly scalable, upstream "blockmer" synthesis remains the primary bottleneck. Advancing RNA Live panelists Claire MacCleod and Jill Caswell discuss the shift from "scaling out" to "scaling up" and lessons learned in the process of achieving larger-scale production. 

  7. Synthetic pDNA: Is It Ready For mRNA Production Primetime? 4/11/2025

    Together, this Advancing RNA panel briefly addresses the ongoing rise of synthetic pDNA, sharing the current benefits and limitations of working with this technology for plasmid production today.

  8. What's Next In IVT Technology? Innovations in Focus 4/11/2025

    Advancing RNA Live panelists delve into advancements in IVT technology, homing in on innovations like bead-based purification, improved enzymes, and modular manufacturing systems.

  9. Overcoming The siRNA Blockmer Production Bottleneck 3/27/2026

    What is the biggest hurdle to reaching metric-ton RNA production? In this segment, Advancing RNA Live speaker Claire McCleod discusses the biggest challenges to producing blockmers and in what ways the industry is reimagining upstream manufacturing to enable more efficient ligation. 

  10. Addressing Industry Challenges In mRNA Product Commercialization

    While the speed of production and flexibility of mRNA are appealing, several industry challenges must still be addressed to realize the full potential and further expand its use.