RNA Supply Chain Videos

1. Synthetic pDNA: Is It Ready For mRNA Production Primetime? 4/11/2025

   Together, this Advancing RNA panel briefly addresses the ongoing rise of synthetic pDNA, sharing the current benefits and limitations of working with this technology for plasmid production today.

2. Addressing mRNA's Scalability And Supply Challenges 3/14/2022

   Tune in as Roberta Duncan, VP of the mRNA program at Seqirus; Duke Human Vaccine Institute Associate Director of Upstream and Downstream Process Development Jason Dickens, Ph.D.; and Jin Zhou, Executive Director of Process Development for mRNA and Protein Biologics at Ultragenyx share supply chain and manufacturing capacity constraints in the face of the urgency to address COVID-19. This is an excerpt from the Bioprocess Online Live event - mRNA Manufacturing: Bright Future, Big Challenges.

3. Effective, Efficient Downstream Purification For Plasmid DNA 4/26/2022

   Learn about a complete purification process flow that overcomes the challenges of producing pDNA – a critical first step in mRNA manufacturing – and covers all downstream unit operations.

4. Next-Generation RNA Modality Supply Considerations

   Together, Life Edit Therapeutics’ April Sena and Sanofi’s Troiano share their perspectives on raw material quality & IP-related considerations for managing the supply chain for next-generation RNA modalities.

5. mRNA Raw Materials To Scale Up Your Manufacturing 11/22/2022

   Learn more about CustomBiotech's mRNA raw materials pipeline and strict quality criteria that are designed to support the success of our customers’ manufacturing scale-up and regulatory drug approval.

6. mRNA Supply Chain And Critical Component Risks 10/16/2023

   What challenges do you consider the most formidable in your own mRNA therapeutic development environments?

7. Defining Phase-Appropriate GMP Principles: Where Do We Start?

   In this excerpt from Advancing RNA Live's Got Raw Materials? The State Of The mRNA Supply Chain featured guests share how they and their teams align around the definition of “phase-appropriate.”

8. Why Our Conversations About Supply Chain Should NOT Overlook This Key Aspect

   When asked which specific topic they’d like to see discussed more regularly in the future as it relates to our supply chains, Featured speakers for the "Got Raw Materials? The State Of The mRNA Supply Chain" event were aligned around this one absolutely critical topic...

9. End-To-End Cold Chain Management: A Next-Generation Approach 2/26/2024

   Three experts in cold chain management walk through the advantages of end-to-end platforms for bulk drug substance management.

10. Analytical Limitations In Assessing Plasmid Quality for mRNA Production 4/11/2025

    There remain a lot of gaps in our understanding of plasmid quality, particularly for high-quality mRNA production (as opposed to viral vector production). In this segment of a recent Advancing RNA Live panel, speakers Adi Nair, Tyler Goodwin, and April Sena highlight their biggest questions around plasmid DNA quality, as well as the pros and cons of some of the analytical methods upon which we’re relying most heavily today to assess plasmid quality.