Video

The Road To Metric-Ton siRNA Production: Is Enzymatic Ligation Ready For Commercial Volume?

Source: Advancing RNA

Can we actually achieve metric-ton siRNA production today using enzymatic ligation? While the ligation step is highly scalable, upstream "blockmer" synthesis remains the primary bottleneck. Advancing RNA Live panelists Claire McCleod and Jill Caswell discuss the shift from "scaling out" to "scaling up" and lessons learned in the process of achieving larger scale production. 

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