RNA Supply Chain Videos

1. Addressing Industry Challenges In mRNA Product Commercialization

   While the speed of production and flexibility of mRNA are appealing, several industry challenges must still be addressed to realize the full potential and further expand its use.

2. Plasmid DNA Downstream Purification Process 4/11/2023

   Large scale production of plasmid DNA requires an in-depth understanding and optimization of the entire downstream process. Explore a complete solution, from harvest to bulk filtration.

3. mRNA Supply Chain And Critical Component Risks 10/16/2023

   What challenges do you consider the most formidable in your own mRNA therapeutic development environments?

4. The 3 C's Of mRNA-LNP Material Sourcing

   In response to an audience poll question gauging which cGMP materials have proven the most difficult to source, our speakers provide additional clarity around which IVT & LNP-related materials today are more “commoditized”.

5. Effective, Efficient Downstream Purification For Plasmid DNA 4/26/2022

   Learn about a complete purification process flow that overcomes the challenges of producing pDNA – a critical first step in mRNA manufacturing – and covers all downstream unit operations.

6. CMC Innovations Worth Watching In The RNA-LNP Space 12/4/2024

   Sanofi’s Sumit Luthra shares several of the analytical and manufacturing innovations/improvements he’s watching and waiting for that will improve our knowledge of LNP composition, structure, function, and quality.

7. What's Next In IVT Technology? Innovations in Focus 4/11/2025

   Advancing RNA Live panelists delve into advancements in IVT technology, homing in on innovations like bead-based purification, improved enzymes, and modular manufacturing systems.

8. Analytical Limitations In Assessing Plasmid Quality for mRNA Production 4/11/2025

   There remain a lot of gaps in our understanding of plasmid quality, particularly for high-quality mRNA production (as opposed to viral vector production). In this segment of a recent Advancing RNA Live panel, speakers Adi Nair, Tyler Goodwin, and April Sena highlight their biggest questions around plasmid DNA quality, as well as the pros and cons of some of the analytical methods upon which we’re relying most heavily today to assess plasmid quality.

9. What Does 2025 (And Beyond) Hold For The RNA-LNP Space? 12/4/2024

   Three LNP experts share their thoughts on the incremental advancements they’d like to see the RNA-LNP space make in the next few years.

10. The Current State Of The mRNA Supply-Chain — In Brief 4/24/2023

    In this Bioprocess Online Live panel, we discuss the current state of the mRNA supply chain for critical raw materials and manufacturing supplies and where pain points still exist.