RNA Supply Chain Videos

1. How Are The Costs Of mRNA-LNP Manufacturing Evolving? 2/10/2025

   Achieving cost-effective manufacturing while maintaining high quality standards today is one of the biggest challenges facing companies outsourcing mRNA/RNA development. In turn, panelists Qian Ruan, Andy Geall, and Alex Aust reflect on how and where they’ve seen the costs of mRNA-LNP manufacturing evolving/fluctuating in recent years.

2. The 3 C's Of mRNA-LNP Material Sourcing

   In response to an audience poll question gauging which cGMP materials have proven the most difficult to source, our speakers provide additional clarity around which IVT & LNP-related materials today are more “commoditized”.

3. Don't Ignore These Functional Areas In Your RNA Therapeutic's Regulatory Story 5/10/2024

   Explore two functional areas that Advancing RNA panelists consider most essential to telling an RNA product’s “story” thoroughly to regulators.

4. Effective, Efficient Downstream Purification For Plasmid DNA 4/26/2022

   Learn about a complete purification process flow that overcomes the challenges of producing pDNA – a critical first step in mRNA manufacturing – and covers all downstream unit operations.

5. CMC Innovations Worth Watching In The RNA-LNP Space 12/4/2024

   Sanofi’s Sumit Luthra shares several of the analytical and manufacturing innovations/improvements he’s watching and waiting for that will improve our knowledge of LNP composition, structure, function, and quality.

6. Oligo Next-Gen Raw Materials: The Two Biggest Shifts In The Supply Chain 12/3/2025

   Camp4’s Satya Kuchimanchi highlights where he has seen the most growth in the oligo supply chain over the past few years, as well as which industry trends have been driving these shifts.

7. The Purification Dilemma: Balancing Upstream & Downstream Investment 10/15/2025

   This Advancing RNA Live clip dives into the biggest challenges in mRNA purification and the critical debate on where to focus investment. Here, our three mRNA PD experts argue for a holistic process development strategy, challenging the traditional wisdom of optimizing the upstream process at any cost.

8. How Could saRNA & circRNA Simplify Manufacturing & Supply Chain Management?

   Explore the broad benefits and challenges that could be encounter by working with self-amplifying and circular RNA modalities — particularly in terms of manufacturing, raw material supply, COGS, and patient centricity.

9. Beyond Cas9: How Diverse Nucleases are Redefining gRNA Design 4/29/2026

   As CRISPR technology evolves beyond the original Cas9, gRNAs are transitioning from simple targeting tools into highly engineered, complex molecules. In this Advancing RNA Live segment, speakers April Sena, Max De Long, and Venkat Krishnamurthy discuss how the rise of diverse nucleases — including prime editors — is impacting gRNA synthesis and purity.

10. What's Next In IVT Technology? Innovations in Focus 4/11/2025

    Advancing RNA Live panelists delve into advancements in IVT technology, homing in on innovations like bead-based purification, improved enzymes, and modular manufacturing systems.