RNA Supply Chain Solutions

  1. Plasmid DNA Manufacturing 1/31/2023

    As a critical starting material in the production of many advanced therapies including viral vectors and RNA vaccines, cell and gene therapy research at any scale requires plasmid DNA manufacturing. Our specialists provide custom plasmid production that fits your project specifications. To save time and accelerate your cell and gene therapy programs, we also offer off-the-shelf, premanufactured, High Quality viral vector packaging plasmids.

  2. in vivo-jetRNA®+ 9/14/2022

    Efficient: 100% mRNA encapsulation leading to comparable LNP delivery results
    in vivo-jetRNA®+ is the reagent of choice to deliver mRNA to various organs. This is attributable to its intrinsic properties: in vivo-jetRNA®+ protects its payload against ubiquitous endonucleases, prevent non-specific interactions with proteins and promote efficient cell entry.

  3. T Cell Kit For mRNA On NanoAssemblr Spark 4/14/2022

    The GenVoy-ILM T Cell Kit for mRNA is optimized for the delivery of mRNA into activated primary human T cells using mRNA-LNPs formulated on the NanoAssemblr Spark instrument and cartridges.

  4. Plasmid DNA Production 6/23/2022

    Integrated manufacturing supporting cell and gene therapies.

    The critical genetic foundation for advanced therapies

    Plasmid DNA is a critical raw material for advanced therapies and mRNA synthesis, supporting their transfection to enable rapid advancement of the therapeutic product. Center for Breakthrough Medicines (CBM) offers capacity dedicated to the development and manufacture of high quality plasmid DNA and other nucleic acids.

  5. jetMESSENGER®: mRNA Transfection Reagent 3/21/2023

    Take your gene expression to the next level by switching to mRNA!

    Primary cells, neurons, suspension cells and various cancer cell lines are especially challenging to transfect. jetMESSENGER® gives high transfection efficiency in all of these usually difficult to transfect cells, by allowing highly efficient mRNA transfection.

    mRNA transfection is as easy as DNA transfection, with the advantage that mRNA does not need to reach the cell nucleus for expression nor require cell division for efficient gene expression. Hence, cells that are slow dividing or that have developed specific mechanisms to protect their genome can finally be used for gene expression.

    Unravel the full potential of your cells by switching to mRNA transfection.

  6. Process Chemicals For RNA Drug Manufacturing

    Make use of our portfolio of raw materials required for mRNA with an integrated offering for all process steps, from plasmid DNA (pDNA) to mRNA synthesis to final formulation.

  7. in vivo mRNA Delivery Using Liposome-Based Reagent 12/12/2022

    in vivo-jetRNA®+ is a ready-to-use reagent that does not require formulation equipment that leads to 100% mRNA encapsulation leading to efficient mRNA delivery.

  8. INDe sgRNAs For Preclinical Safety, Toxicity, And Efficacy Studies 11/29/2023

    Seamlessly transition from discovery to delivery with INDe sgRNAs. These quality sgRNAs can be synthesized in quantities from milligrams to grams and follow high purity specifications.

  9. New Next-Generation GMP Facility 5/16/2023

    A new state-of-the-art GMP facility has been created to accelerate the development of CRISPR-based cell and gene therapies, overcoming challenges such as procuring reliable GMP-grade sgRNA persist.