RNA Supply Chain Solutions

  1. Fit-For-Purpose And GMP Grade mRNA Reagents 3/24/2025

    Ensure the safety and efficacy of your mRNA therapeutics with high-quality, GMP-grade reagents from a trusted partner with a multi-tiered quality approach to deliver manufacturing certainty.

  2. GMP sgRNA Manufacturing 11/30/2023

    Transition from early-phase research through process development into the clinic with these continuum sgRNA available in different grades.

  3. Plasmid DNA Production 6/23/2022

    Integrated manufacturing supporting cell and gene therapies.

    The critical genetic foundation for advanced therapies

    Plasmid DNA is a critical raw material for advanced therapies and mRNA synthesis, supporting their transfection to enable rapid advancement of the therapeutic product. Center for Breakthrough Medicines (CBM) offers capacity dedicated to the development and manufacture of high quality plasmid DNA and other nucleic acids.

  4. mRNA Raw Materials: Supporting Your Journey To Market 12/5/2025

    Implementing a quality-by-design approach for manufacturing inputs limits contamination risks and simplifies regulatory compliance. Validated processes ensure consistency when scaling operations.

  5. Product Launch: Vaccinia Capping System mRNA Guanylyltransferase And mRNA Methyltransferase 12/5/2025

    mRNA Vaccinia Capping System: Proven. Scalable. Tailored to the needs of biopharma companies developing mRNA-based therapies.

  6. INDe sgRNAs For Preclinical Safety, Toxicity, And Efficacy Studies 11/29/2023

    Seamlessly transition from discovery to delivery with INDe sgRNAs. These quality sgRNAs can be synthesized in quantities from milligrams to grams and follow high purity specifications.

  7. in vivo-jetRNA®+ 9/14/2022

    Efficient: 100% mRNA encapsulation leading to comparable LNP delivery results
    in vivo-jetRNA®+ is the reagent of choice to deliver mRNA to various organs. This is attributable to its intrinsic properties: in vivo-jetRNA®+ protects its payload against ubiquitous endonucleases, prevent non-specific interactions with proteins and promote efficient cell entry.

  8. Mitigate Contamination Risks With HTST Flash Pasteurization 5/2/2024

    Gibco™ High-temperature, short-time (HTST) treatment of raw materials

    HTST treatment currently available in North America

    Simple sugar batch sizes ranging from 800 to 8,800 L

    In-house HTST preparation can be expensive and cumbersome. Outsourcing this technology to Thermo Fisher Scientific can alleviate production bottlenecks and increase viral mitigation confidence.

    Suitable and cost-effective for large volumes

    Standard and custom bioprocessing containers available (5 L–1,000 L). Please contact your sales representative.

  9. Vaccinia Capping System For mRNA Therapeutics 12/5/2025

    Backed by over a decade of expertise in capping enzyme production, this system is a robust, scalable solution designed to support production journeys from early R&D to full-scale manufacturing.

  10. GenVoy-ILM™ T Cell Kit For mRNA, Ignite™ 7/1/2022

    GenVoy-ILM™ T Cell Kit for mRNA, Ignite is an lipid nanoparticle (LNP) reagent mix optimized for the delivery of messenger RNA (mRNA) or Cas9 mRNA/sgRNA into activated human primary T cells.