RNA Supply Chain Solutions

1. GMP sgRNA Manufacturing 11/30/2023

   Transition from early-phase research through process development into the clinic with these continuum sgRNA available in different grades.

2. Plasmid DNA Production 6/23/2022

   Integrated manufacturing supporting cell and gene therapies.

   The critical genetic foundation for advanced therapies

   Plasmid DNA is a critical raw material for advanced therapies and mRNA synthesis, supporting their transfection to enable rapid advancement of the therapeutic product. Center for Breakthrough Medicines (CBM) offers capacity dedicated to the development and manufacture of high quality plasmid DNA and other nucleic acids.

3. Product Launch: Vaccinia Capping System mRNA Guanylyltransferase And mRNA Methyltransferase 12/5/2025

   mRNA Vaccinia Capping System: Proven. Scalable. Tailored to the needs of biopharma companies developing mRNA-based therapies.

4. Fit-For-Purpose And GMP Grade mRNA Reagents 3/24/2025

   Ensure the safety and efficacy of your mRNA therapeutics with high-quality, GMP-grade reagents from a trusted partner with a multi-tiered quality approach to deliver manufacturing certainty.

5. Excellence For Cell And Gene Therapy Manufacturing 6/4/2025

   Unlock the potential of advanced therapies with dedicated partnership and tailored manufacturing solutions, ensuring quality and efficiency from discovery through to delivery for next-generation treatments.

6. Prima Product Line Up 3/17/2026

   Discover how specialized RNA polymerase variants solve yield, purity, and capping challenges across different template lengths, with substantive improvements over standard T7 polymerase performance.

7. in vivo-jetRNA®+ 9/14/2022

   Efficient: 100% mRNA encapsulation leading to comparable LNP delivery results
   in vivo-jetRNA^®+ is the reagent of choice to deliver mRNA to various organs. This is attributable to its intrinsic properties: in vivo-jetRNA^®+ protects its payload against ubiquitous endonucleases, prevent non-specific interactions with proteins and promote efficient cell entry.

8. Plasmid DNA Manufacturing 1/31/2023

   As a critical starting material in the production of many advanced therapies including viral vectors and RNA vaccines, cell and gene therapy research at any scale requires plasmid DNA manufacturing. Our specialists provide custom plasmid production that fits your project specifications. To save time and accelerate your cell and gene therapy programs, we also offer off-the-shelf, premanufactured, High Quality viral vector packaging plasmids.

9. jetMESSENGER®: mRNA Transfection Reagent 3/21/2023

   Take your gene expression to the next level by switching to mRNA!

   Primary cells, neurons, suspension cells and various cancer cell lines are especially challenging to transfect. jetMESSENGER® gives high transfection efficiency in all of these usually difficult to transfect cells, by allowing highly efficient mRNA transfection.

   mRNA transfection is as easy as DNA transfection, with the advantage that mRNA does not need to reach the cell nucleus for expression nor require cell division for efficient gene expression. Hence, cells that are slow dividing or that have developed specific mechanisms to protect their genome can finally be used for gene expression.

   Unravel the full potential of your cells by switching to mRNA transfection.

10. New Next-Generation GMP Facility 5/16/2023

    A new state-of-the-art GMP facility has been created to accelerate the development of CRISPR-based cell and gene therapies, overcoming challenges such as procuring reliable GMP-grade sgRNA persist.