RNA Supply Chain Solutions

1. Advancing Innovative Plasmid DNA Manufacturing Solutions For CGT 3/13/2025

   Having produced over 185,000 DNA lots, including 5,000+ cGMP batches, we are a trusted partner in plasmid DNA production from discovery to commercialization.

2. Plasmid DNA Manufacturing 1/31/2023

   As a critical starting material in the production of many advanced therapies including viral vectors and RNA vaccines, cell and gene therapy research at any scale requires plasmid DNA manufacturing. Our specialists provide custom plasmid production that fits your project specifications. To save time and accelerate your cell and gene therapy programs, we also offer off-the-shelf, premanufactured, High Quality viral vector packaging plasmids.

3. Plasmid DNA Production 6/23/2022

   Integrated manufacturing supporting cell and gene therapies.

   The critical genetic foundation for advanced therapies

   Plasmid DNA is a critical raw material for advanced therapies and mRNA synthesis, supporting their transfection to enable rapid advancement of the therapeutic product. Center for Breakthrough Medicines (CBM) offers capacity dedicated to the development and manufacture of high quality plasmid DNA and other nucleic acids.

4. jetMESSENGER®: mRNA Transfection Reagent For Hard-To-Transfect Cells 3/21/2023

   Learn about a highly efficient and gentle mRNA transfection reagent designed for outstanding transfection efficiency in hard-to-transfect cells, finally allowing relevant gene expression experiments in almost all cell types.

5. High-Fidelity Nuclease For Therapeutic Breakthroughs 10/28/2024

   The hfCas12Max nuclease offers superior gene editing with high fidelity, broad PAM recognition, minimal off-target effects, and compatibility across cell types for therapeutic applications.

6. New Next-Generation GMP Facility 5/16/2023

   A new state-of-the-art GMP facility has been created to accelerate the development of CRISPR-based cell and gene therapies, overcoming challenges such as procuring reliable GMP-grade sgRNA persist.

7. Brochure: The Power Of Small: Nanoplasmid™ Vector Platform 1/19/2023

   With gene therapy advancing at a record pace, Aldevron recognizes the enormous promise your work can bring to therapeutics. We are proud to deliver a superior, modern plasmid technology to your therapeutic endeavors.

8. in vivo mRNA Delivery Using Liposome-Based Reagent 12/12/2022

   in vivo-jetRNA^®+ is a ready-to-use reagent that does not require formulation equipment that leads to 100% mRNA encapsulation leading to efficient mRNA delivery.

9. jetMESSENGER®: mRNA Transfection Reagent 3/21/2023

   Take your gene expression to the next level by switching to mRNA!

   Primary cells, neurons, suspension cells and various cancer cell lines are especially challenging to transfect. jetMESSENGER® gives high transfection efficiency in all of these usually difficult to transfect cells, by allowing highly efficient mRNA transfection.

   mRNA transfection is as easy as DNA transfection, with the advantage that mRNA does not need to reach the cell nucleus for expression nor require cell division for efficient gene expression. Hence, cells that are slow dividing or that have developed specific mechanisms to protect their genome can finally be used for gene expression.

   Unravel the full potential of your cells by switching to mRNA transfection.

10. GenVoy-ILM™ T Cell Kit For mRNA, Ignite™ 7/1/2022

    GenVoy-ILM™ T Cell Kit for mRNA, Ignite is an lipid nanoparticle (LNP) reagent mix optimized for the delivery of messenger RNA (mRNA) or Cas9 mRNA/sgRNA into activated human primary T cells.