RNA Supply Chain Resources

  1. GMP-Source® And Phase-Appropriate Use For Early-Stage Clinical Trials 9/16/2021

    GMP-Source is a more robust, less rigid alternative to full cGMP production that mirrors nearly all of the oversight and quality standards of full cGMP production while relaxing certain commercial standards, helping companies overcome the hurdles that can stall early development.

  2. Uninterrupted Supply To Meet Demand 1/23/2024

    Explore a solution for biopharmaceutical companies concerned about the risks an increase in campaign volume can pose to their production timeline.

  3. The Role Of CRISPR Cas9 Plasmids In Gene-Editing 12/12/2023

    Plasmids are crucial for CRISPR-Cas9 gene-editing technology, and their role in CRISPR is expected to evolve with ongoing research.

  4. Where Can Novel Non-Viral Polymeric Delivery Agents Take Us? 1/18/2023

    Explore ongoing work to harness different types of HDR templates in order to build cutting-edge systems with the potential to enable point-of-care cell and gene therapy manufacture.

  5. Transitioning From Using RUO To cGMP Chemicals For Clinical Trials 10/17/2023

    Learn about the common challenges and risks associated with accelerating your molecule's timeline from lab to clinic, along with important supply chain considerations for emerging biopharma companies.

  6. cGMP Assurance of Supply Services 1/23/2024

    Explore the stocking solution offered to a mid-sized CDMO in need of a high volume of safety stock inventory to support their customer portfolio growth.

  7. Eliminating Antibiotic Resistance Gene Transfer Risks In CGTs 8/14/2023

    Learn about the drawbacks of antibiotic resistance that can cause side effects in patients and how an antibiotic-free approach can ease the burden of regulatory compliance and accelerate development.

  8. mRNA Transfection Reagent Enhances Non-Viral Gene Delivery To Stem Cells 6/27/2022

    Researchers demonstrate a delivery mechanism that is a simple and ready-to-use transfection reagent that leads to outstanding transfection efficiencies in known hard-to-transfect stem cells.

  9. Chromatographic Purification Of Plasmid DNA 11/19/2020

    Widespread application of pDNA in gene therapy is driving increased demand and as a response, plasmid manufacturing must become more efficient with improved productivity. Intensification of chromatographic steps can help address this demand and has led to an exploration of the use of convective media (monoliths, membranes, fibre based technologies).

  10. Novel Lipid Nanoparticle Delivery Reagent And Manufacturing Workflow 4/18/2022

    We aim to highlight that commercially available LNP reagent mix, GenVoy-ILM, is an accessible and easy-to-use LNP formulation that allows for rapid preclinical development of RNA vaccines.