RNA Supply Chain Resources

1. Mastering mRNA Manufacturing: A Focus on Raw Materials & Supply Assurance 10/23/2024

   Rapid advancements in mRNA-based therapeutic development have underscored the role of raw material quality and supply chain management in ensuring their successful production.

2. mRNA Synthesis Reagents And Manufacturing 8/14/2023

   As novel mRNA therapies are starting to enter clinical stages of development, Aldevron is providing critical support in a number of ways with specialized products and services.

3. Transitioning From Using RUO To cGMP Chemicals For Clinical Trials 10/17/2023

   Learn about the common challenges and risks associated with accelerating your molecule's timeline from lab to clinic, along with important supply chain considerations for emerging biopharma companies.

4. Consolidating The Supply Chain For mRNA 2/12/2024

   Learn about the first end-to-end cGMP facility that was developed for mRNA manufacturing to address the shortage of CDMOs and the inadequate and inefficient supply chain options for sourcing GMP mRNA.

5. GMP-Source® And Phase-Appropriate Use For Early-Stage Clinical Trials 9/16/2021

   GMP-Source is a more robust, less rigid alternative to full cGMP production that mirrors nearly all of the oversight and quality standards of full cGMP production while relaxing certain commercial standards, helping companies overcome the hurdles that can stall early development.

6. A Novel RNA Lipid Nanoparticle Platform: Gene-Edited CAR T Cells For Off-The-Shelf Cancer Therapy 4/14/2022

   We report on the use of a novel lipid nanoparticle (LNP) reagent in a validated protocol to achieve successful complex gene editing in primary T cells with high efficiency while maintaining high cell viability.

7. Review Of mRNA Vaccines & Therapeutics Manufacturing Challenges: Plasmid DNA Manufacturing 6/7/2022

   This review suggests technical remedial options for the production of pDNA and focuses on mRNA synthesis, purification, and encapsulation.

8. The Key To Improving Global Supply Chain Resilience 6/10/2024

   Explore the past, present, and future of supply chain security, ways the biopharma industry can secure supply chains and minimize risks, and more.

9. The Source Of GMP- How Client Demand Drives Innovation 1/13/2021

   GMP-Source, which is a term we coined, serves the purpose as a highly qualified raw material for a generation of virus, messenger RNA template, and transgenic expression of proteins. 

10. Pioneering The Future Of Pharmaceutical Supply Chains

    Drive the efficiency and resiliency of supply chains by integrating automation, AI, and effective communication, ensuring the successful distribution of lifesaving medicinal products.