RNA Supply Chain Resources

1. The Evolution Of Nucleotide Production 4/2/2025

   From harsh chemicals to gentle enzymes: Explore the groundbreaking shift in nucleotide synthesis, making drug manufacturing cleaner, greener, and more efficient.

2. GMP-Source® And Phase-Appropriate Use For Early-Stage Clinical Trials 9/16/2021

   GMP-Source is a more robust, less rigid alternative to full cGMP production that mirrors nearly all of the oversight and quality standards of full cGMP production while relaxing certain commercial standards, helping companies overcome the hurdles that can stall early development.

3. CRISPR sgRNA For Successful Gene Editing: Discovery To Clinic 9/25/2023

   The single guide RNA (sgRNA) is one of the key components of successful CRISPR gene editing. Here we cover all the important aspects of sgRNA and Synthego’s sgRNA products.

4. Why Risk Analysis And Lane Qualification Matter 5/28/2026

   Risk analysis and lane qualification show supply chains perform consistently, meeting regulatory expectations by demonstrating control, reducing variability, and ensuring reliable delivery.

5. Novel Lipid Nanoparticle Delivery Reagent And Manufacturing Workflow 4/18/2022

   We aim to highlight that commercially available LNP reagent mix, GenVoy-ILM, is an accessible and easy-to-use LNP formulation that allows for rapid preclinical development of RNA vaccines.

6. Delivering Global Media Manufacturing Consistency Through Site-To-Site Equivalency 7/8/2024

   Explore a program focused on achieving process consistency through risk mitigation in four key areas: raw materials sourcing, equipment, manufacturing processes, and finished product testing.

7. Building Stability Through Integrated Cryopreservation 3/30/2026

   Early integration of standardized, GMP-aligned cryopreservation improves consistency, documentation, and scalability in advanced therapy programs as they progress toward regulatory submissions.

8. Demystifying CRISPR gRNA Chemical Modifications 10/28/2024

   Chemical modifications on CRISPR gRNAs enhance stability, editing efficiency, and reduce immune responses, enabling in vivo applications and clinical success.

9. The Source Of GMP- How Client Demand Drives Innovation 1/13/2021

   GMP-Source, which is a term we coined, serves the purpose as a highly qualified raw material for a generation of virus, messenger RNA template, and transgenic expression of proteins. 

10. Chromatographic Purification Of Plasmid DNA 11/19/2020

    Widespread application of pDNA in gene therapy is driving increased demand and as a response, plasmid manufacturing must become more efficient with improved productivity. Intensification of chromatographic steps can help address this demand and has led to an exploration of the use of convective media (monoliths, membranes, fibre based technologies).