RNA Supply Chain Resources

1. Reduce Contamination Risks When Storing Synthetic DNA 10/30/2023

   An alternative to traditional polyethylene bags is offering cell and gene therapy manufacturers a solution to contamination concerns regarding DNA or RNA fragments.

2. mRNA Transfection Reagent Enhances Non-Viral Gene Delivery To Stem Cells 6/27/2022

   Researchers demonstrate a delivery mechanism that is a simple and ready-to-use transfection reagent that leads to outstanding transfection efficiencies in known hard-to-transfect stem cells.

3. Chromatographic Purification Of Plasmid DNA 11/19/2020

   Widespread application of pDNA in gene therapy is driving increased demand and as a response, plasmid manufacturing must become more efficient with improved productivity. Intensification of chromatographic steps can help address this demand and has led to an exploration of the use of convective media (monoliths, membranes, fibre based technologies).

4. A Novel RNA Lipid Nanoparticle Platform: Gene-Edited CAR T Cells For Off-The-Shelf Cancer Therapy 4/14/2022

   We report on the use of a novel lipid nanoparticle (LNP) reagent in a validated protocol to achieve successful complex gene editing in primary T cells with high efficiency while maintaining high cell viability.

5. The Role Of CRISPR Cas9 Plasmids In Gene-Editing 12/12/2023

   Plasmids are crucial for CRISPR-Cas9 gene-editing technology, and their role in CRISPR is expected to evolve with ongoing research.

6. The Source Of GMP- How Client Demand Drives Innovation 1/13/2021

   GMP-Source, which is a term we coined, serves the purpose as a highly qualified raw material for a generation of virus, messenger RNA template, and transgenic expression of proteins. 

7. Overcome Vaccine Development Complexities With The Right Supply Chain Partner 7/5/2022

   Explore the challenges impacting clinical supply chains and solutions to overcome these complexities, and understand why it is crucial to pick the right supply chain provider for vaccine storage and distribution.

8. Delivering Global Media Manufacturing Consistency Through Site-To-Site Equivalency 7/8/2024

   Explore a program focused on achieving process consistency through risk mitigation in four key areas: raw materials sourcing, equipment, manufacturing processes, and finished product testing.

9. mRNA Vaccine Development: Planning, Workflow, Supply Chain Success 5/17/2022

   A review of insights derived from the development of mRNA-based COVID-19 vaccines and how they can be applied to accelerate progress in the manufacture of vaccines and therapeutics moving forward.

10. Novel Lipid Nanoparticle Delivery Reagent And Manufacturing Workflow 4/18/2022

    We aim to highlight that commercially available LNP reagent mix, GenVoy-ILM, is an accessible and easy-to-use LNP formulation that allows for rapid preclinical development of RNA vaccines.