RNA Supply Chain Resources

1. Gene And Cell Therapy: Planning For Manufacturing Success Early 1/16/2023

   As gene therapy organizations are asked to balance the need for rapid clinical progression and stringent quality expectations, explore how to optimize plasmid production and reach patients with efficiency.

2. Demystifying CRISPR gRNA Chemical Modifications 10/28/2024

   Chemical modifications on CRISPR gRNAs enhance stability, editing efficiency, and reduce immune responses, enabling in vivo applications and clinical success.

3. Review Of mRNA Vaccines & Therapeutics Manufacturing Challenges: Plasmid DNA Manufacturing 6/7/2022

   This review suggests technical remedial options for the production of pDNA and focuses on mRNA synthesis, purification, and encapsulation.

4. Mastering mRNA Manufacturing: A Focus on Raw Materials & Supply Assurance 10/23/2024

   Rapid advancements in mRNA-based therapeutic development have underscored the role of raw material quality and supply chain management in ensuring their successful production.

5. The Key To Improving Global Supply Chain Resilience 6/10/2024

   Explore the past, present, and future of supply chain security, ways the biopharma industry can secure supply chains and minimize risks, and more.

6. The Role Of CRISPR Cas9 Plasmids In Gene-Editing 12/12/2023

   Plasmids are crucial for CRISPR-Cas9 gene-editing technology, and their role in CRISPR is expected to evolve with ongoing research.

7. Moderna's Regulatory Journey: 3 Takeaways To Foster The mRNA Renaissance 1/2/2024

   The story of how Moderna brought one of the first mRNA vaccines to the market has all the makings of a legend we will pass down through generations. However, unlike the legends of King Arthur or The Fountain of Youth, we can celebrate that Moderna’s legendary journey was — and still is — real. Not only did the mRNA vaccines help return life to normal, but they also kickstarted the mRNA therapeutic renaissance we’re happily experiencing today.

8. Chromatographic Purification Of Plasmid DNA 11/19/2020

   Widespread application of pDNA in gene therapy is driving increased demand and as a response, plasmid manufacturing must become more efficient with improved productivity. Intensification of chromatographic steps can help address this demand and has led to an exploration of the use of convective media (monoliths, membranes, fibre based technologies).

9. The Source Of GMP- How Client Demand Drives Innovation 1/13/2021

   GMP-Source, which is a term we coined, serves the purpose as a highly qualified raw material for a generation of virus, messenger RNA template, and transgenic expression of proteins. 

10. mRNA Synthesis Reagents And Manufacturing 8/14/2023

    As novel mRNA therapies are starting to enter clinical stages of development, Aldevron is providing critical support in a number of ways with specialized products and services.