RNA Supply Chain Resources

1. The Key To Improving Global Supply Chain Resilience 6/10/2024

   Explore the past, present, and future of supply chain security, ways the biopharma industry can secure supply chains and minimize risks, and more.

2. GMP-Source® And Phase-Appropriate Use For Early-Stage Clinical Trials 9/16/2021

   GMP-Source is a more robust, less rigid alternative to full cGMP production that mirrors nearly all of the oversight and quality standards of full cGMP production while relaxing certain commercial standards, helping companies overcome the hurdles that can stall early development.

3. The Source Of GMP- How Client Demand Drives Innovation 1/13/2021

   GMP-Source, which is a term we coined, serves the purpose as a highly qualified raw material for a generation of virus, messenger RNA template, and transgenic expression of proteins. 

4. Where Can Novel Non-Viral Polymeric Delivery Agents Take Us? 1/18/2023

   Explore ongoing work to harness different types of HDR templates in order to build cutting-edge systems with the potential to enable point-of-care cell and gene therapy manufacture.

5. Demystifying CRISPR gRNA Chemical Modifications 10/28/2024

   Chemical modifications on CRISPR gRNAs enhance stability, editing efficiency, and reduce immune responses, enabling in vivo applications and clinical success.

6. Supercharge Your Supply Chain: Harness AI To Gain Competitive Advantage

   The success of CGTs hinges upon adherence to specific logistics protocols. Learn how the integration of AI in the pharma supply chain is poised to enhance visibility, efficiency, and compliance.

7. Expectations On The Pathway To GMP For Gene-Modified Cell Therapies 6/21/2023

   Learn how a robust understanding of the RNP’s critical process parameters and CQAs is crucial for ensuring product consistency, enhancing patient safety, and maintaining regulatory compliance.

8. mRNA Transfection Reagent Enhances Non-Viral Gene Delivery To Stem Cells 6/27/2022

   Researchers demonstrate a delivery mechanism that is a simple and ready-to-use transfection reagent that leads to outstanding transfection efficiencies in known hard-to-transfect stem cells.

9. Reduce Contamination Risks When Storing Synthetic DNA 10/30/2023

   An alternative to traditional polyethylene bags is offering cell and gene therapy manufacturers a solution to contamination concerns regarding DNA or RNA fragments.

10. Chromatographic Purification Of Plasmid DNA 11/19/2020

    Widespread application of pDNA in gene therapy is driving increased demand and as a response, plasmid manufacturing must become more efficient with improved productivity. Intensification of chromatographic steps can help address this demand and has led to an exploration of the use of convective media (monoliths, membranes, fibre based technologies).