Articles, App Notes, Case Studies, & White Papers

  1. CRISPR Off-Target Editing: Prediction, Analysis, And More 2/28/2025

    A crucial consideration for researchers is off-target editing – unintended DNA modifications at sites other than the intended target. Explore the complexities and strategies to mitigate these effects.

  2. A Multiplexed High Throughput Method To Evaluate Novel Nuclease Activity 2/24/2025

    Efficiently evaluating the activity of novel nucleases with unique properties requires a high-throughput, multiplexed approach that enables direct comparison across multiple genomic targets.

  3. Difco TC Yeastolate Ultra-Filtered (TCY UF) In Scale-Up Optimization 10/30/2024

    Explore how Difco™ TC Yeastolate ultra-filtered (TCY UF) enabled over 100% improvement in titer for CHO cell culture through feed optimization and bioreactor scalability in a real-world application.

  4. A Risk-Based Approach To Validation Studies For Sterilizing-Grade Filtration And Single-Use Systems 10/3/2024

    One way to address risk related to product quality is by implementing a Question-Based Review approach. Read on to learn about this approach and its advantages.

  5. Process Effects On Drug Product Quality In Pharmaceutical Manufacturing 5/30/2019

    Here, we discuss the importance of understanding how critical process parameters can impact a product’s critical quality attributes and how a systematic approach with validated SPR assays can help in this respect.

  6. PEG In LNP Formulations: Addressing Challenges And Seeking Solutions 2/8/2024

    Polyethylene glycol and similar variants have driven innovative research for therapies. However, the continued use of PEG poses significant drawbacks.

  7. Platform Technology Revolutionizing The Biopharmaceutical Industry 1/12/2024

    Learn how mRNA technology is significantly reshaping the biopharmaceutical industry, potentially revolutionizing medicine and playing a crucial role in the rapid development of vaccines.

  8. Enhanced mAb Production With High-Intensity Perfusion CHO Medium 11/27/2024

    Reach new heights in mAb production with a high-intensity perfusion CHO medium designed to support consistently high product yield and quality in continuous perfusion cultures using CHO-K1 cells.

  9. Review Of mRNA Vaccines & Therapeutics Manufacturing Challenges: Plasmid DNA Manufacturing 6/7/2022

    This review suggests technical remedial options for the production of pDNA and focuses on mRNA synthesis, purification, and encapsulation.

  10. The "Unique" Opportunity Presented by Southeast Asia 2/26/2025

    Southeast Asia has emerged as a pivotal region for vaccine clinical trials, driven by rapid recruitment, cost efficiency, and robust immunization infrastructure.