The Importance Of Linear Scalability In Nanoparticle Processing: From Benchtop Research To Commercial Manufacturing

The path from a successful nanomedicine discovery in the lab to a viable commercial product is often slowed by a critical manufacturing hurdle: non-linear scalability. This challenge arises because traditional mixing methods, which work well on a small benchtop, fail to reproduce the same particle attributes—like size, polydispersity, and stability—when scaled up to larger volumes. This inconsistency forces costly reformulation, delays clinical trials, and increases regulatory risk.

The key to overcoming this is linear scalability, which guarantees that the same process dynamics and outcomes are maintained from milliliter-scale research through full commercial production. This consistency accelerates development by allowing early-stage data to remain valid throughout. The enabling technology for this is turbulent jet mixing. This method uses high-energy, reproducible turbulence to achieve instantaneous, homogeneous mixing across any scale. By following predictable scaling laws, turbulent jet mixing ensures the hydrodynamic environment remains identical, allowing manufacturers to reliably produce high-quality nanoparticles batch after batch.

Learn how embracing this advanced mixing technology can transform your development timeline and reduce the risk in your nanomedicine pipeline.