Articles, App Notes, Case Studies, & White Papers

1. SARS-CoV-2 Viral RNA Extraction From Human Saliva Samples With NAB Nanosep® Centrifugal Devices 9/13/2021

   In this study we evaluate the performance of the Pall NAB Nanosep centrifugal device for the isolation of SARS-CoV-2 viral RNA from human saliva samples spiked with heat inactivated virus using reagents (RCOM1 and RCOM2) from two commercially available kits for extraction of viral RNA.

2. Is A Rapid Cooling Step Needed When Freezing Cells For Cryopreservation? 3/6/2019

   A “rapid-cooling nucleation step” is hypothesized to improve ice nucleation – an important event for good post-thaw outcomes. Explore how a rapid-cooling nucleation step affects viable cell count and activity of four cell lines.

3. Establishing Analytical Methods For mRNA-Based Therapies 6/13/2023

   Here, we provide a detailed description of assays for sequence identification and LNP composition in mRNA-LNP products that support the development of safe and effective mRNA therapies.

4. Single-Use Systems For Vaccine Manufacturing 10/29/2019

   Next-gen vaccines will leverage recombinant approaches and intensified single-use systems (SUS) to increase capacity at reduced costs, but SUS suppliers will need to overcome regulatory challenges.

5. CMC Strategies For A Bispecific Antibody Platform For Cancer Immunotherapy 5/31/2019

   Bispecific antibody development presents many challenges in product expression, bispecific purification, product stability, and scale up of the manufacturing process. 

6. Metabolite ID And Relative Quantification Of Oligonucleotides In Plasma 3/4/2022

   This technical note describes the identification, relative quantification, and structural confirmation of the chain-shortened metabolites of a phosphorothioated oligonucleotide.

7. A New Specialist For Oligonucleotides With Advantages 12/16/2025

   Discover how hybrid silica technologies ensure stability and high resolution in IP-RP chromatography applications while protecting instrumentation from excessive wear and tear.

8. Purifying Plasmid DNA Using A Modern Chromatography Resin 2/5/2020

   Through an industry collaboration, Cobra and Cytiva were able to combine their expertise and experience and create a solution to meet the rising demand for high quality plasmid DNA.

9. Developing A Scalable RNA-LNP Drug Product For Clinical Translation 9/22/2022

   Accelerate essential process development activities with instrumentation solution allowing for highly reproducible and scalable production of RNA-LNPs.

10. Considerations And Strategies For Oligonucleotide Manufacturing Scale-Up 8/2/2023

    To keep up with oligonucleotide demand, manufacturing needs to shift toward larger-scale processes, but this scale-up process brings challenges that must be addressed.