Articles, App Notes, Case Studies, & White Papers

1. The Key To Accelerating RNA-LNP Drug Development 12/27/2023

   Learn about the drug development hurdles that must be overcome to deliver on the promise of mRNA.

2. In-Process Control Of pDNA Production On CIMac™ pDNA Analytical Column 6/10/2021

   As the demand for plasmid DNA (pDNA) based gene therapy and vaccines increases, large-scale, cost-effective, and reproducible pDNA production is required. The key to success is a real-time in-process control method that ensures a high percentage of supercoiled pDNA in the final product. Read how the CIMac™ pDNA Analytical Column allows the monitoring of degradation products (open circular and linear pDNA), the removal of impurities (RNA), and ensures that each production step yields the amount of supercoiled pDNA anticipated.

3. From Cell Culture To Target Protein: Exploring The Benefits Of The 24-Well Filter Plate Workflow 2/12/2021

   Over the last 5 years, the use of 24-well cell culture plates in laboratory applications has substantially increased. This market segment has expanded at an estimated 14% compound annual growth rate (CAGR)— a pace that is expected to continue in coming years. This paper explores the evaluation of the potential applications for its new AcroPrep 24-well filter plate line, plus the time savings it can achieve in protein purification workflows.

4. Future-Proofing mRNA Drug Manufacturing: The Value of Continuous Improvement 4/30/2024

   With so many uncertainties permeating the mRNA market, this largely preclinical industry is still seeking answers on how to reach successful therapeutic development. Identifying optimizations, both sequence-dependent and otherwise, to enhance the manufacturing process is crucial for advancing mRNA product development, which holds vast potential to address a wide range of indications.

5. Fast Track RNA-LNP Drug Development By Lowering The Lipid Barrier 8/21/2023

   Fast-track RNA-LNP development, streamline screening with off-the-shelf ionizable lipid mixes, and utilize validation strategies to generate reproducible and scalable LNPs for lead candidates.

6. Liver Cancer — Global Clinical Trial Landscape (2024) 7/3/2024

   Explore the latest advancements and clinical trial landscape in liver cancer research with Novotech CRO's comprehensive disease report.

7. A Proven Platform For Solid-Phase Oligonucleotide Synthesis 5/25/2022

   Facilitating oligonucleotide synthesis with state-of-the-art equipment and process support is critical to maximizing oligo production and achieving consistency at scale.

8. Treating Deficiencies In Employee Training And Mentorship 5/3/2024

   Investing in employee training and development is not just beneficial for the employees. It also contributes significantly to the organization’s success and competitive advantage.

9. Purification Of DNA Oligonucleotides Using An Anion Exchange Resin 2/23/2022

   Learn how a strong anion exchange resin can be used for the efficient purification of single-stranded DNA oligonucleotides used in clinical trials.

10. Determining RNA Integrity And Purity By Capillary Gel Electrophoresis 6/30/2023

    To ensure mRNA product quality, it's important to confirm the integrity of the RNA. Examine the results of a study challenging the performance of the CGE method in assessing mRNA integrity and purity.