Newsletter | September 9, 2026

09.09.26 -- What Baby KJ Taught Us About mRNA COGS

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FEATURED EDITORIAL

What Baby KJ Taught Us About mRNA COGS

Here, in part 2 of this three-part series, I share a few details that came to light about the COGS behind Baby KJ’s therapy production. Obviously, we know why it’s important to keep these figures in mind as we move forward; but I particularly liked Strauss’ reminder that it’s our job to “think systematically about how we’re going to create a safety net of sustainable, accessible product that can be widely distributed at an affordable cost.”

Building The RNA Knowledge Graph: How Better Annotation Is Accelerating Therapeutic Discovery

As RNA therapeutics grow more complex, better biological annotation is becoming the foundation for AI-driven discovery, target selection, and smarter drug development.

Location Matters: How The Nuclear Geography Of circRNAs Could Shape The Future Of RNA Therapeutics

CircRNA location may be as important as its sequence. Discover how nuclear organization could influence the next generation of RNA therapeutics.

Nucleic Acid Ligases: Connecting The Pieces For Sustainable And Scalable Production Of Oligonucleotide Therapeutics

Chemoenzymatic ligation could overcome the scalability and sustainability limits of traditional oligonucleotide manufacturing, enabling more efficient RNA drug production.

INDUSTRY INSIGHTS

Pushing The Boundaries Of Chromatographic Separation

Metal-sensitive analytes often suffer from poor recovery and distorted peak shapes. Learn how inert hardware improves sensitivity and chromatographic performance for challenging analyses.

The Playbook For Accelerating Cell Banking To Clinical Production

Accelerate your path to the clinic with an integrated, risk-based cell banking strategy that delivers speed, quality, and regulatory confidence at every stage.

Understanding mRNA Technology As A Platform For Biopharma

Discover the advantages of mRNA technology, the process steps of large-scale mRNA production, and the effect of common contaminants on mRNA manufacturing.

Laminar And Turbulent Mixing Techniques For LNP Formulations Scale Up

Explore the critical factors in scaling up lipid nanoparticle (LNP) formulation, comparing the advantages and limitations of both laminar (microfluidic) and turbulent (tee and jet) mixing technologies.

The Strategic Landscape Of Domestic Biomanufacturing Risk Reduction

Domestic pharmaceutical manufacturing strengthens supply chain resilience, simplifies distribution, speeds market response, and reduces risk by aligning production with key markets.

Why CGT Programs Need A Different CRO Mindset

Advanced therapies need bioanalysis partners built for complexity, not scale. CGT expertise, specialized platforms, and flexible timelines ensure dosing and safety data traditional CROs can’t support.

SOLUTIONS

Streamline Your mRNA Purification Steps

Oligonucleotide Synthesizer Overview

Do Even More Than Liquid Chromatography