RNA Supply Chain Solutions

1. Fit-For-Purpose And GMP Grade mRNA Reagents 3/24/2025

   Ensure the safety and efficacy of your mRNA therapeutics with high-quality, GMP-grade reagents from a trusted partner with a multi-tiered quality approach to deliver manufacturing certainty.

2. Advancing Innovative Plasmid DNA Manufacturing Solutions For CGT 3/13/2025

   Having produced over 185,000 DNA lots, including 5,000+ cGMP batches, we are a trusted partner in plasmid DNA production from discovery to commercialization.

3. GMP sgRNA Manufacturing 11/30/2023

   Transition from early-phase research through process development into the clinic with these continuum sgRNA available in different grades.

4. High-Fidelity Nuclease For Therapeutic Breakthroughs 10/28/2024

   The hfCas12Max nuclease offers superior gene editing with high fidelity, broad PAM recognition, minimal off-target effects, and compatibility across cell types for therapeutic applications.

5. INDe sgRNAs For Preclinical Safety, Toxicity, And Efficacy Studies 11/29/2023

   Seamlessly transition from discovery to delivery with INDe sgRNAs. These quality sgRNAs can be synthesized in quantities from milligrams to grams and follow high purity specifications.

6. Process Chemicals For RNA Drug Manufacturing

   Make use of our portfolio of raw materials required for mRNA with an integrated offering for all process steps, from plasmid DNA (pDNA) to mRNA synthesis to final formulation.

7. jetMESSENGER®: mRNA Transfection Reagent For Hard-To-Transfect Cells 3/21/2023

   Learn about a highly efficient and gentle mRNA transfection reagent designed for outstanding transfection efficiency in hard-to-transfect cells, finally allowing relevant gene expression experiments in almost all cell types.

8. Plasmid DNA Production 6/23/2022

   Integrated manufacturing supporting cell and gene therapies.

   The critical genetic foundation for advanced therapies

   Plasmid DNA is a critical raw material for advanced therapies and mRNA synthesis, supporting their transfection to enable rapid advancement of the therapeutic product. Center for Breakthrough Medicines (CBM) offers capacity dedicated to the development and manufacture of high quality plasmid DNA and other nucleic acids.

9. Synthetic Research Grade sgRNA Manufacturing For CRISPR Experiments 11/28/2023

   Consistently achieve high editing efficiency and quick turnaround time in as little as 7 days with synthetic sgRNA that pave your way to a successful CRISPR experiment.

10. jetMESSENGER®: mRNA Transfection Reagent 3/21/2023

    Take your gene expression to the next level by switching to mRNA!

    Primary cells, neurons, suspension cells and various cancer cell lines are especially challenging to transfect. jetMESSENGER® gives high transfection efficiency in all of these usually difficult to transfect cells, by allowing highly efficient mRNA transfection.

    mRNA transfection is as easy as DNA transfection, with the advantage that mRNA does not need to reach the cell nucleus for expression nor require cell division for efficient gene expression. Hence, cells that are slow dividing or that have developed specific mechanisms to protect their genome can finally be used for gene expression.

    Unravel the full potential of your cells by switching to mRNA transfection.