RNA Supply Chain Solutions

  1. High-Fidelity Nuclease For Therapeutic Breakthroughs 10/28/2024

    The hfCas12Max nuclease offers superior gene editing with high fidelity, broad PAM recognition, minimal off-target effects, and compatibility across cell types for therapeutic applications.

  2. Advancing Innovative Plasmid DNA Manufacturing Solutions For CGT 3/13/2025

    Having produced over 185,000 DNA lots, including 5,000+ cGMP batches, we are a trusted partner in plasmid DNA production from discovery to commercialization.

  3. in vivo mRNA Delivery Using Liposome-Based Reagent 12/12/2022

    in vivo-jetRNA®+ is a ready-to-use reagent that does not require formulation equipment that leads to 100% mRNA encapsulation leading to efficient mRNA delivery.

  4. Product Launch: Vaccinia Capping System mRNA Guanylyltransferase And mRNA Methyltransferase 12/5/2025

    mRNA Vaccinia Capping System: Proven. Scalable. Tailored to the needs of biopharma companies developing mRNA-based therapies.

  5. mRNA Raw Materials: Supporting Your Journey To Market 12/5/2025

    Implementing a quality-by-design approach for manufacturing inputs limits contamination risks and simplifies regulatory compliance. Validated processes ensure consistency when scaling operations.

  6. Synthetic Research Grade sgRNA Manufacturing For CRISPR Experiments 11/28/2023

    Consistently achieve high editing efficiency and quick turnaround time in as little as 7 days with synthetic sgRNA that pave your way to a successful CRISPR experiment.

  7. GenVoy-ILM™ T Cell Kit For mRNA, Ignite™ 7/1/2022

    GenVoy-ILM™ T Cell Kit for mRNA, Ignite is an lipid nanoparticle (LNP) reagent mix optimized for the delivery of messenger RNA (mRNA) or Cas9 mRNA/sgRNA into activated human primary T cells.

  8. Plasmid DNA Production 6/23/2022

    Integrated manufacturing supporting cell and gene therapies.

    The critical genetic foundation for advanced therapies

    Plasmid DNA is a critical raw material for advanced therapies and mRNA synthesis, supporting their transfection to enable rapid advancement of the therapeutic product. Center for Breakthrough Medicines (CBM) offers capacity dedicated to the development and manufacture of high quality plasmid DNA and other nucleic acids.

  9. Process Chemicals For RNA Drug Manufacturing

    Make use of our portfolio of raw materials required for mRNA with an integrated offering for all process steps, from plasmid DNA (pDNA) to mRNA synthesis to final formulation.

  10. GMP sgRNA Manufacturing 11/30/2023

    Transition from early-phase research through process development into the clinic with these continuum sgRNA available in different grades.